Bone strength in young healthy females, older patients with low-trauma fracture and older healthy adults: peripheral quantitative computed tomography based finite element analysis
Osteoporosis is a major health problem affecting Australia’s ageing population due to the associated increased risk of fragility fracture. The currently utilised dual energy x-ray absorptiometry (DXA) has limitations in fracture prediction. Peripheral quantitative computed tomography (pQCT) is an alternative technique for determination of bone mineral measures that is applicable in a clinical setting, and is a suitable source for finite element analysis (FEA).
The objectives of this study are:
- To describe the normal distribution of relevant pQCT variables including FEA-derived bone strength parameters and the determinants of these parameters in healthy young women;
- To obtain bone strength variables determined by pQCT-based FEA models in patients with LTF, and compare them to those of healthy controls;
- To evaluate the potential clinical utility of pQCT-based FEA models for the assessment of bone fragility.
We are currently recruiting participants for three groups: healthy young females, older patients with low-trauma fracture and older healthy adults. We will request them to undergo both DXA and pQCT test and gather other data including demographics and fracture risks.
- John D Wark, Professor of Medicine, Head of Bone and Mineral Medicine RMH
- Peter Vee Sin Lee, Professor, Deputy Head of Department of Mechanical Engineering
- Dale Robinson, postdoctoral research fellow
- Christopher Yates, senior endocrinology registrar
- Alexandra Gorelik, senior statistician
- Hongyuan Jiang, PhD student
- Ashwini Kale, Senior Bone Densitometrist
We are collaborating with Professor Peter Lee's research group at Mechanical Engineering of the University of Melbourne. Prof. Peter Lee and Dr Dale Robinson are involved in bone model simulation and finite element analysis.
- Hongyuan Jiang, Christopher Yates, Alexandra Goreliks, Ashwini Kale, Qichun Song, John D Wark. Peripheral quantitative computed tomography measures contribute to the understanding of bone fragility in low-trauma fracture patients. Presented at the European Calcified Tissue Society Conference 2016, Rome, Italy. Bone Abstracts Issue 1 Volume 5 LB3.