Bone strength in young healthy females, older patients with low-trauma fracture and older healthy adults: peripheral quantitative computed tomography based finite element analysis
Osteoporosis is a major health problem affecting Australia’s ageing population due to the associated increased risk of fragility fracture. The currently utilised dual energy x-ray absorptiometry (DXA) has limitations in fracture prediction. Peripheral quantitative computed tomography (pQCT) is an alternative technique for determination of bone mineral measures that is applicable in a clinical setting, and is a suitable source for finite element analysis (FEA).
The objectives of this study are:
- To describe the normal distribution of relevant pQCT variables including FEA-derived bone strength parameters and the determinants of these parameters in healthy young women;
- To obtain bone strength variables determined by pQCT-based FEA models in patients with LTF, and compare them to those of healthy controls;
- To evaluate the potential clinical utility of pQCT-based FEA models for the assessment of bone fragility.
We are currently recruiting participants for three groups: healthy young females, older patients with low-trauma fracture and older healthy adults. We will request them to undergo both DXA and pQCT test and gather other data including demographics and fracture risks.
- John D Wark, Professor of Medicine, Head of Bone and Mineral Medicine RMH
- Peter Vee Sin Lee, Professor, Deputy Head of Department of Mechanical Engineering
- Dale Robinson, postdoctoral research fellow
- Christopher Yates, senior endocrinology registrar
- Alexandra Gorelik, senior statistician
- Hongyuan Jiang, PhD student
- Ashwini Kale, Senior Bone Densitometrist
We are collaborating with Professor Peter Lee's research group at Mechanical Engineering of the University of Melbourne. Prof. Peter Lee and Dr Dale Robinson are involved in bone model simulation and finite element analysis.
Hongyuan Jiang, Christopher Yates, Alexandra Gorelik, Ashwini Kale, Qichun Song & John D Wark. Peripheral quantitative computed tomography measures contribute to the understanding of bone fragility in low-trauma fracture patients. Journal of Clinical Densitometry, 2017(16): 30197-4. doi: 10.1016/j.jocd.2017.02.003.
Hongyuan Jiang, Christopher Yates, Alexandra Gorelik, Ashwini Kale, Qichun Song & John D Wark. Peripheral quantitative computed tomography measures contribute to the understanding of bone fragility in low-trauma fracture patients. Bone Abstracts (2016) 5 LB3. DOI:10.1530/boneabs.5.LB3. Presented at the 43rd Annual European Calcified Tissue Society Congress in Rome, Italy, 14-17 May 2016.
Dale Robinson, Qichun Song, Hongyuan Jiang, Peter Lee, John D Wark. Finite Element Analysis Based in pQCT Imaging To Improve Assessment of Fracture Risk. Presented at the ASBMR 2016 Annual Meeting, Atlanta, Georgia, USA, 16-19 September 2016.
Dale L Robinson, Qichun Song, Hongyuan Jiang, Martha Hickey, Peter Vee Sin Lee, John D Wark. Enhanced fracture risk classification based on finite element modelling of clinical tibia pQCT. Presented at 17th Congress of the International Society of Biomechanics in Brisbane, Queensland, Australia, 23-27 July 2017.
Hongyuan Jiang, Dale L Robinson, Matthew McDonald, Saija Kontulainen, James D Johnston, Peter VS Lee, John D Wark. Prediction of Distal Radius Failure Load Using Finite Element Modelling of Peripheral Quantitative Computed tomography (pQCT-FE): A validation study. Accepted to be presented at the ASBMR 2017 Annual Meeting, Denver Colorado USA, 8-11 September 2017 and the pre-meeting symposia: Current Concept in Bone Fragility: From Cells to Surrogates, Denver Colorado USA, 7 September 2017.