Genomics of adverse response to antiepileptic drugs

Project Details

Although highly efficacious, antiepileptic drugs (AEDs) are associated with a range of side effects. This project will focus on two types of side effects: skin reactions and psychosis, which are severe and largely unpredictable by clinical risk factors but likely to have a strong genetic basis. Identifying the genetic markers will help patient selection and inform future drug development.  

Severe cutaneous adverse drug reactions (cADRs), such as Stevens Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), are among the most feared adverse effects of antiepileptic drugs (AEDs) not only because of their high mortality and morbidity, but also because of their unpredictability. Dissecting the genetic basis for these ADRs will have major impact on “personalised” drug selection, and the insights gained on the chemico-biological pathways will help future design of safer medications.  

This project represents an exceptional opportunity to effectively and efficiently discover these variants in a unique subject cohort (drug-exposed cases and controls) using the latest genotyping and sequencing platforms. More than one student will be needed for various aspects, including patient recruitment and phenotyping. In addition, there will be opportunity for the student to be part of the data analysis team, thus basic knowledge in bioinformatics and genetic statistics is essential.

Research Opportunities

This research project is available to PhD students to join as part of their thesis.
Please contact the Research Group Leader to discuss your options.

Research Group

Epilepsy and Precision Medicine



Faculty Research Themes

Neuroscience

School Research Themes

Neuroscience & Psychiatry



Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Medicine and Radiology

Unit / Centre

Epilepsy and Precision Medicine