Research in the Hamilton Laboratory has a major focus on inflammation. Inflammation is increasingly being seen to have a significant impact on many chronic diseases such as arthritis, atherosclerosis and cancer.
The core biology involves that of the macrophage lineage. A variety of techniques and strategies are utilised including gene-based strategies (e.g RNA-seq, ChIP-Seq and micro-array technologies) to understand disease causation, protein-based strategies (including proteomics, immunoprecipitation, cell transfection) to study the cellular signal transduction pathways associated with disease, and mouse models and clinical material to analyse disease in vivo.
Key components of the biology involve an analysis of how macrophage lineage cells are altered during inflammatory disease, how at a molecular level these cells survive, proliferate, differentiate or are activated, and how to down-regulate the cellular functions aberrant in disease. There is some emphasis on growth factor biology/biochemistry and on signal transduction pathways implicated strongly in human arthritis.
- Prof John Hamilton
- A/Prof Andrew Cook
- Dr Adrian Achuthan
- Dr Andrew Fleetwood
- Dr Anne Christensen
- Dr Ming-Chin Lee
- Ms Ashlee Frye
- Professor Stephen Nutt, Walter and Eliza Hall Institute of Medical Research
- Professor Stephen Turner, Monash University
- Professor Robin Anderson, Peter MacCallum Cancer Centre
- Professor Eric Reynolds, Melbourne Dental School
This group receives funding from the National Health & Medical Research Council.
- The role of granulocyte macrophage colony stimulating factor (GM-CSF) in arthritis and inflammation
- Molecular signaling pathways controlling gene expression during chronic disease progression
- A new host-pathogen interaction in arthritis
- Elucidating molecular signalling pathways controlled by anti-inflammatory steroids
- GM-CSF-mediated molecular signalling pathways contributing to inflammation
Faculty Research Themes
For further information about this research, please contact Professor John Hamilton