GM-CSF-mediated molecular signalling pathways contributing to inflammation

  • Project Lead

    Dr Adrian Achuthan
    T: +61 3 8344 3298
    E: aaa@unimelb.edu.au
    W: Personal web page

    Location: Dept of Medicine, Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria 3050, Australia.

Project Details

GM-CSF is a pro-survival factor for monocytes, macrophages and granulocytes, and can activate them for enhanced inflammatory mediator levels. Depletion of GM-CSF has been shown to suppress arthritis in animal models. Clinical trials in rheumatoid arthritis (RA) targeting GM-CSF or its receptor have reported success in Phase II, although its mode of action remains unknown. Recent data from our laboratory suggested that a GM-CSF regulated chemokine CCL17 could be critical for the pro-inflammatory actions of GM-CSF. This project will investigate whether GM-CSF-mediated CCL17 production contributes to the inflammatory cytokine production in RA synovium and synovial macrophages/dendritic cells.

Researchers

Research Opportunities

This research project is available to PhD students to join as part of their thesis.
Please contact the Research Group Leader to discuss your options.

Research Group

Hamilton Laboratory



Faculty Research Themes

Infection and Immunology



Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Medicine and Radiology

Unit / Centre

Hamilton Laboratory