The role of granulocyte macrophage colony stimulating factor (GM-CSF) in arthritis and inflammation

Project Details

Rheumatoid arthritis (RA) is a chronic inflammatory disease affecting approximately 1% of the population. We have shown that GM-CSF is important for the development of several models of inflammation and arthritis. Furthermore, blockade of GM-CSF is effective at reducing arthritis severity and arthritic pain. Phase 1 clinical trials are now underway in human rheumatoid arthritis. However, we still do not completely understand how GM-CSF is acting during inflammation and arthritis. We are investigating the role of GM-CSF in inflammatory and arthritic pain and disease, including how GM-CSF interacts with other mediators and what downstream events GM-CSF is controlling during inflammation.

Researchers

Funding

This group receives funding from the National Health & Medical Research Council.

Research Outcomes

  1. Louis C, Cook AD, Lacey D, Fleetwood AJ, Vlahos R, Anderson GP, Hamilton JA. Specific contributions of CSF-1 and GM-CSF to the dynamics of the mononuclear phagocyte system. J Immunol 2015; 195: 134-44.  
  2. Cook AD, Pobjoy J, Sarros S, Steidl S, Dürr M, Lacey DC, Hamilton JA. Granulocyte-macrophage colony-stimulating factor is a key mediator in inflammatory and arthritic pain. Ann Rheum Dis. 2013; 72: 265-70.  
  3. Cook AD, Pobjoy J, Steidl S, Dürr M, Braine EL, Turner AL, Lacey DC, Hamilton JA. Granulocyte macrophage-colony stimulating factor is a key mediator in experimental osteoarthritis pain and disease development. Arthritis Res Ther. 2012; 14: R199.  
  4. Cook AD, Turne, AL, Braine EL, Pobjoy J, Lenzo JC, Hamilton JA. Bone marrow cell-derived granulocyte-macrophage colony-stimulating factor regulates systemic and local myeloid populations in inflammatory arthritis. Arthritis Rheum. 2011; 63: 40-51.
  5. Cook AD, Braine EL, Hamilton JA. Stimulus-dependent requirement for GM-CSF in inflammation. J. Immunol. 2004; 173: 4643-51.
  6. Cook AD, Braine EL, Campbell IK, Rich MJ, Hamilton JA. Blockade of collagen-induced arthritis post-onset by antibody to granulocyte-macrophage colony-stimulating factor (GM-CSF): requirement for GM-CSF in the effector phase of disease. Arthritis Res. 2001; 3: 293-8.

Research Publications

  1. Louis C, Cook AD, Lacey D, Fleetwood AJ, Vlahos R, Anderson GP, Hamilton JA. Specific contributions of CSF-1 and GM-CSF to the dynamics of the mononuclear phagocyte system. J Immunol 2015; 195: 134-44.  
  2. Cook AD, Pobjoy J, Sarros S, Steidl S, Dürr M, Lacey DC, Hamilton JA. Granulocyte-macrophage colony-stimulating factor is a key mediator in inflammatory and arthritic pain. Ann Rheum Dis. 2013; 72: 265-70.  
  3. Cook AD, Pobjoy J, Steidl S, Dürr M, Braine EL, Turner AL, Lacey DC, Hamilton JA. Granulocyte macrophage-colony stimulating factor is a key mediator in experimental osteoarthritis pain and disease development. Arthritis Res Ther. 2012; 14: R199.  
  4. Cook AD, Turne, AL, Braine EL, Pobjoy J, Lenzo JC, Hamilton JA. Bone marrow cell-derived granulocyte-macrophage colony-stimulating factor regulates systemic and local myeloid populations in inflammatory arthritis. Arthritis Rheum. 2011; 63: 40-51.
  5. Cook AD, Braine EL, Hamilton JA. Stimulus-dependent requirement for GM-CSF in inflammation. J. Immunol. 2004; 173: 4643-51.
  6. Cook AD, Braine EL, Campbell IK, Rich MJ, Hamilton JA. Blockade of collagen-induced arthritis post-onset by antibody to granulocyte-macrophage colony-stimulating factor (GM-CSF): requirement for GM-CSF in the effector phase of disease. Arthritis Res. 2001; 3: 293-8.

Research Group

Hamilton Laboratory



Faculty Research Themes

Infection and Immunology



Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Medicine and Radiology

Unit / Centre

Hamilton Laboratory