The role of granulocyte macrophage colony stimulating factor (GM-CSF) in arthritis and inflammation

Project Details

Rheumatoid arthritis (RA) is a chronic inflammatory disease affecting approximately 1% of the population. We have shown that GM-CSF is important for the development of several models of inflammation and arthritis. Furthermore, blockade of GM-CSF is effective at reducing arthritis severity and arthritic pain. Phase 1 clinical trials are now underway in human rheumatoid arthritis. However, we still do not completely understand how GM-CSF is acting during inflammation and arthritis. We are investigating the role of GM-CSF in inflammatory and arthritic pain and disease, including how GM-CSF interacts with other mediators and what downstream events GM-CSF is controlling during inflammation.

Researchers

Funding

This group receives funding from the National Health & Medical Research Council.

Research Opportunities

This research project is available to PhD students to join as part of their thesis.
Please contact the Research Group Leader to discuss your options.

Research Outcomes

  1. Louis C, Cook AD, Lacey D, Fleetwood AJ, Vlahos R, Anderson GP, Hamilton JA. Specific contributions of CSF-1 and GM-CSF to the dynamics of the mononuclear phagocyte system. J Immunol 2015; 195: 134-44.  
  2. Cook AD, Pobjoy J, Sarros S, Steidl S, Dürr M, Lacey DC, Hamilton JA. Granulocyte-macrophage colony-stimulating factor is a key mediator in inflammatory and arthritic pain. Ann Rheum Dis. 2013; 72: 265-70.  
  3. Cook AD, Pobjoy J, Steidl S, Dürr M, Braine EL, Turner AL, Lacey DC, Hamilton JA. Granulocyte macrophage-colony stimulating factor is a key mediator in experimental osteoarthritis pain and disease development. Arthritis Res Ther. 2012; 14: R199.  
  4. Cook AD, Turne, AL, Braine EL, Pobjoy J, Lenzo JC, Hamilton JA. Bone marrow cell-derived granulocyte-macrophage colony-stimulating factor regulates systemic and local myeloid populations in inflammatory arthritis. Arthritis Rheum. 2011; 63: 40-51.
  5. Cook AD, Braine EL, Hamilton JA. Stimulus-dependent requirement for GM-CSF in inflammation. J. Immunol. 2004; 173: 4643-51.
  6. Cook AD, Braine EL, Campbell IK, Rich MJ, Hamilton JA. Blockade of collagen-induced arthritis post-onset by antibody to granulocyte-macrophage colony-stimulating factor (GM-CSF): requirement for GM-CSF in the effector phase of disease. Arthritis Res. 2001; 3: 293-8.

Research Publications

  1. Louis C, Cook AD, Lacey D, Fleetwood AJ, Vlahos R, Anderson GP, Hamilton JA. Specific contributions of CSF-1 and GM-CSF to the dynamics of the mononuclear phagocyte system. J Immunol 2015; 195: 134-44.  
  2. Cook AD, Pobjoy J, Sarros S, Steidl S, Dürr M, Lacey DC, Hamilton JA. Granulocyte-macrophage colony-stimulating factor is a key mediator in inflammatory and arthritic pain. Ann Rheum Dis. 2013; 72: 265-70.  
  3. Cook AD, Pobjoy J, Steidl S, Dürr M, Braine EL, Turner AL, Lacey DC, Hamilton JA. Granulocyte macrophage-colony stimulating factor is a key mediator in experimental osteoarthritis pain and disease development. Arthritis Res Ther. 2012; 14: R199.  
  4. Cook AD, Turne, AL, Braine EL, Pobjoy J, Lenzo JC, Hamilton JA. Bone marrow cell-derived granulocyte-macrophage colony-stimulating factor regulates systemic and local myeloid populations in inflammatory arthritis. Arthritis Rheum. 2011; 63: 40-51.
  5. Cook AD, Braine EL, Hamilton JA. Stimulus-dependent requirement for GM-CSF in inflammation. J. Immunol. 2004; 173: 4643-51.
  6. Cook AD, Braine EL, Campbell IK, Rich MJ, Hamilton JA. Blockade of collagen-induced arthritis post-onset by antibody to granulocyte-macrophage colony-stimulating factor (GM-CSF): requirement for GM-CSF in the effector phase of disease. Arthritis Res. 2001; 3: 293-8.

Research Group

Hamilton Laboratory


Research Themes

Infection and Immunity


Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Medicine and Radiology