Melbourne EpiCentre

Research Overview

The Melbourne EpiCentre is a collaborative research centre of the University of Melbourne and Melbourne Health embedded within the Royal Melbourne Hospital. It is an academic centre of excellence with research, education, health care quality and safety, and organisation-improvement agenda.

Melbourne EpiCentre is a National Collaborative Research Infrastructure Strategy (NCRIS) funded facility, with expertise in the planning, design, data management, statistical and clinical reporting of clinical trials, conforming to FDA requirements and industry standards.

The EpiCentre is leading several early and late phase clinical trials and clinical epidemiological projects with large primary and ambulatory care databases from the US and UK. The EpiCentre also provides study design, data management and biostatistical support for diverse research groups across the University and Melbourne Health, as well as providing analytical support for data relating to health care services quality and safety.

The Centre's key research areas are:

  1. Clinical trials
  2. Clinical epidemiology research
  3. Health services research
  4. Methodological research

Staff

Associate Staff

Collaborators

AUSTRALIAN COLLABORATORS:

  • Therapeutic Innovation Australia – Queensland Node
  • Melbourne Ageing Research Collaboration (MARC)
  • Department of Health and Human Services, Victoria
  • National Ageing Research Institute (NARI)
  • Burns, Trauma and Critical Care Research Centre, University of Queensland
  • Centre for Clinical Research, University of Queensland
  • Centre for Research in Geriatric Medicine, University of Queensland
  • Diamantina Institute, University of Queensland
  • School of Health and Rehabilitation Sciences, University of Queensland
  • School of Allied Health Sciences, Griffith University
  • Baker IDI Heart & Diabetes Institute, Melbourne
  • OzStar Therapeutics Pty Ltd
  • Diabetes and Endocrinology Department, Princess Alexandra Hospital, Queensland Health
  • Bone Marrow Transplant Laboratory

INTERNATIONAL:

  • Imperial College London, UK
  • University of Oxford, UK
  • University of Leicester, UK
  • University of North Carolina, USA
  • University of Minnesota, USA
  • Bristol-Myers Squibb: Amylin Pharmaceuticals, USA
  • Genentech
  • Medtronic
  • Novo Nordisk A/S, Denmark
  • AstraZeneca
  • Chinese Academy of Sciences, China
  • Peking University, China
  • Guangzhou Zhongyi Pharmaceutical Co. Ltd., China
  • Agilent Technologies Inc., USA

Funding

  • Paul S. Translating Health Discovery (THD) NCRIS 2016 Funding Program, 2016 -
  • Paul S. Effect of weight change and its interactions with glycaemic control and blood pressure on cardiovascular and mortality risks in patients with type 2 diabetes – A Part of Programme of Clinical Epidemiological Studies. AstraZeneca Investigator Initiated Research Grant. 2016-18.
  • Roberts JR, Lipman J, Peake S, Turnidge J, Slavin M, Hopkins P, Bulitta J, Paul S (Chief Investigator), de Waele J, Joynt G. Centre for Redefining antibiotic use to reduce resistance and prolong the lives of antibiotics (REDUCE). NHMRC Centre of Research Excellence, 2016-20.
  • Beck B, Rubin C, Paul S (Chief Investigator), Forwood M. Whole body vibration for osteoporosis: Shaking up our treatment options. NHMRC Project Grant, 2015-19.
  • Paul S, Atherton J. Evaluation of the association of old and new anti-diabetes drugs with the risk of heart failure in patients with type 2 diabetes. RBWH Foundation, 2016-18.
  • Paul S (Lead Chief Investigator), Shaw J, Majeed A, Khunti K, Klein K. Evaluation of the obesity paradox in diabetes: A longitudinal case-control study of half a million patients. NHMRC Project Grant, 2014-18
  • Roberts JA, Lipman J, Peake S, Roberts MS, Paul S (Chief Investigator), Turnidge J.  Robust antibiotic dosing for critically ill patients receiving renal replacement therapy. NHMRC Project Grant (Roberts J et al.), 2013-18.
  • Paul S (Principal Statistician / Investigator). Telehealth in residential aged care facilities: a pragmatic randomized control trial. NHMRC Project Grant (Gray L et al.), 2013 -
  • The Dementia Care Pathway for use in acute hospitals: development, implementation and evaluation funded by the Victorian Department of Health & Melbourne Health. Commenced 1/2014.
  • Strategies for Relatives (START) Online. State Trustees and MARC. Commenced 7/2016.
  • Preventing Avoidable Hospital Admissions for People with Dementia. State Trustees and MARC. Commenced 5/2016.

Research Publications

For a complete list of Prof Sanjoy Paul's publications click here.

Melbourne EpiCentre 2017 publications:

  1. Montvida, O., J. Shaw, J. Atherton, F. Stringer and S. Paul (2017). "Long-term Trends in Antidiabetic Drug Usage in the USA: Real-world Evidence in Newly Diagnosed Type 2 Diabetes Patients." Diabetes Care In Press.
  2. Paul, S. and R. Holman (2017). "Do glycoalbumin levels preferentially reflect changes in postprandial glucose excursions?" Diabetic Medicine.
  3. Paul, S., O. Montvida, J. Best, S. Gale, A. Pethoe-Schramm and K. Sarsour (2017). THU0167 Association of biologic antirheumatic therapy with the risk of developing type 2 diabetes in adults with rheumatoid arthritis: new evidence from real world data, BMJ Publishing Group Ltd.
  4. Paul, S. K., O. Montvida, J. H. Best, S. Gale, A. Pethoe-Schramm and K. Sarsour (2017). Effectiveness of Biologic and Non-biologic Antirheumatic Drugs on Anaemia Markers in 153,788 Patients with Rheumatoid Arthritis: New Evidence from Real-World Data. Seminars in Arthritis and Rheumatism, WB Saunders.
  5. Paul, S. K., E. S. Owusu Adjah, M. Samanta, K. Patel, S. Bellary, W. Hanif and K. Khunti (2017). "Comparison of body mass index at diagnosis of diabetes in a multi‐ethnic population: A case‐control study with matched non‐diabetic controls." Diabetes, Obesity and Metabolism.
  6. Montvida, O., O. Arandelovic, E. Reiner and S. K. Paul (2017). "Data mining approach to estimate the duration of drug therapy from longitudinal electronic medical records." Open Bioinformatics Journal.
  7. Montvida, O., K. Klein, S. Kumar, K. Khunti and S. K. Paul (2017). "Addition of or switch to insulin therapy in people treated with glucagon‐like peptide‐1 receptor agonists: A real‐world study in 66 583 patients." Diabetes, Obesity and Metabolism 19(1): 108-117.
  8. Tropea, J., D. LoGiudice and L. Kelly (2017). "People with dementia in the emergency department: Behavioural symptoms and use of restraint." Emerg Med Australas 29(5): 605-606.
  9. Tropea, J., D. LoGiudice, D. Liew, A. Gorelik and C. Brand (2017). "Poorer outcomes and greater healthcare costs for hospitalised older people with dementia and delirium: a retrospective cohort study." Int J Geriatr Psychiatry 32(5): 539-547.
  10. Tropea, J., D. LoGiudice, D. Liew, C. Roberts and C. Brand (2017). "Caring for people with dementia in hospital: findings from a survey to identify barriers and facilitators to implementing best practice dementia care." Int Psychogeriatr 29(3): 467-474.
  11. Luo, Y., S. K. Paul, X. Zhou, C. Chang, W. Chen, X. Guo, J. Yang, L. Ji and H. Wang (2017). "Rationale, Design, and Baseline Characteristics of Beijing Prediabetes Reversion Program: A Randomized Controlled Clinical Trial to Evaluate the Efficacy of Lifestyle Intervention and/or Pioglitazone in Reversion to Normal Glucose Tolerance in Prediabetes." Journal of diabetes research 2017.
  12. Matthews, M., M. S. Rathleff, A. Claus, T. McPoil, R. Nee, et al. S.K. Paul (2017). "The Foot Orthoses versus Hip eXercises (FOHX) trial for patellofemoral pain: a protocol for a randomized clinical trial to determine if foot mobility is associated with better outcomes from foot orthoses." Journal of Foot and Ankle Research 10(1): 5.
  13. Zhang, X., H. Sun, S. K. Paul, Q. Wang, X. Lou, G. Hou, B. Wen, L. Ji and S. Liu et al. A Gorelik (2017). "The serum protein responses to treatment with Xiaoke Pill and Glibenclamide in type 2 diabetes patients." Clinical proteomics 14(1): 19.
  14. Ackerman, I. N., C. Pratt, A. Gorelik and D. Liew (2017). "The projected burden of osteoarthritis and rheumatoid arthritis in Australia: A population-level analysis." Arthritis Care Res (Hoboken).
  15. Anderson, M. A., C. Tam, T. E. Lew, S. Juneja, M. Juneja, et al. A Gorelik (2017). "Clinicopathological features and outcomes of progression of CLL on the BCL2 inhibitor venetoclax." Blood 129(25): 3362-3370.
  16. Bishop, B., N. Hannah, A. Doyle, F. Amico, B. Hockey, et al. A Gorelik (2017). The first prospective study of drug-induced liver injury due to volatile anesthetic agents: Incidence and risk factors. Journal of gastroenterology and hepatology, NJ USA. 32: 87
  17. Callegari, E. T., S. M. Garland, A. Gorelik, C. Chiang and J. D. Wark (2017). "ANNALS EXPRESS: Bone turnover marker determinants in young women: results from the Safe-D study." Ann Clin Biochem: 4563217719734.
  18. Callegari, E. T., S. M. Garland, A. Gorelik, N. J. Reavley and J. D. Wark (2017). "Predictors and correlates of serum 25-hydroxyvitamin D concentrations in young women: results from the Safe-D study." Br J Nutr 118(4): 263-272.
  19. Callegari, E. T., S. M. Garland, A. Gorelik and J. D. Wark (2017). "Determinants of bone mineral density in young Australian women; results from the Safe-D study." Osteoporos Int.
  20. Callegari, E. T., S. M. Garland, A. Gorelik and J. D. Wark (2017). "Erratum to: Determinants of bone mineral density in young Australian women; results from the Safe-D study." Osteoporos Int 28(11): 3287-3288.
  21. Callegari, E. T., A. Gorelik, S. M. Garland, C. Y. Chiang and J. D. Wark (2017). "Bone turnover marker reference intervals in young females." Ann Clin Biochem 54(4): 438-447.
  22. Callegari, E. T., N. Reavley, A. Gorelik, S. M. Garland, J. D. Wark and D. s. t. Safe (2017). "Serum 25-hydroxyvitamin D and mental health in young Australian women: Results from the Safe-D study." J Affect Disord 224: 48-55.
  23. Furler, J., D. O'Neal, J. Speight, J. A. Manski-Nankervis, A. Gorelik, et al. (2017). "Supporting insulin initiation in type 2 diabetes in primary care: results of the Stepping Up pragmatic cluster randomised controlled clinical trial." BMJ 356: j783.
  24. Hamilton, A. L., M. A. Kamm, P. De Cruz, E. K. Wright, F. Selvaraj, et al. A Gorelik (2017). "Serologic antibodies in relation to outcome in postoperative Crohn's disease." J Gastroenterol Hepatol 32(6): 1195-1203.
  25. Harris, N., A. Gorelik and R. N. Gibson (2017). "Targeted ultrasound of the liver: Impact on scanning time of a new approach in chronic liver disease." J Med Imaging Radiat Oncol 61(4): 448-452.
  26. Huq, A. J., M. Bogwitz, A. Gorelik, I. M. Winship, S. M. White and A. H. Trainer (2017). "Cohort study of Gorlin syndrome with emphasis on standardised phenotyping and quality of life assessment." Intern Med J 47(6): 664-673.
  27. Jackson, B., D. Con, R. Ma, A. Gorelik, D. Liew and P. De Cruz (2017). "Health care costs associated with Australian tertiary inflammatory bowel disease care." Scand J Gastroenterol 52(8): 851-856.
  28. Jiang, H., C. J. Yates, A. Gorelik, A. Kale, Q. Song and J. D. Wark (2017). "Peripheral Quantitative Computed Tomography (pQCT) Measures Contribute to the Understanding of Bone Fragility in Older Patients With Low-trauma Fracture." J Clin Densitom.
  29. Luk, E. K., A. Gorelik, L. Irving and F. Khan (2017). "Effectiveness of cognitive behavioural therapy in a community-based pulmonary rehabilitation programme: A controlled clinical trial." J Rehabil Med 49(3): 264-269.
  30. Pattison, D. A., M. Bozin, A. Gorelik, M. S. Hofman, R. J. Hicks and A. Skandarajah (2017). "18F-fluorodeoxyglycose-avid thyroid incidentalomas: the importance of contextual interpretation." J Nucl Med.
  31. Pattison, D. A., M. Bozin, A. Gorelik, M. S. Hofman, R. J. Hicks and A. Skandarajah (2017). "18F-fluorodeoxyglycose-avid thyroid incidentalomas: the importance of contextual interpretation." Journal of Nuclear Medicine.
  32. Seah, D., M. C. Choy, A. Gorelik, W. R. Connell, M. P. Sparrow, D. van Langenberg, G. Hebbard, G. Moore and P. De Cruz (2017). "Examining maintenance care following infliximab salvage therapy for acute severe ulcerative colitis." J Gastroenterol Hepatol.
  33. Shiek Ahmad, B., S. J. Petty, A. Gorelik, T. J. O'Brien, K. D. Hill, J. J. Christie, P. N. Sambrook and J. D. Wark (2017). "Bone loss with antiepileptic drug therapy: a twin and sibling study." Osteoporos Int.
  34. Smallwood, N., N. Gaffney, A. Gorelik, L. Irving, B. Le and J. Philip (2017). "Junior doctors' attitudes to opioids for refractory breathlessness in patients with advanced chronic obstructive pulmonary disease." Intern Med J 47(9): 1050-1056.
  35. Subasinghe, A. K., J. D. Wark, A. Gorelik, E. T. Callegari and S. M. Garland (2017). "The association between inflammation, obesity and elevated blood pressure in 16-25-year-old females." J Hum Hypertens 31(9): 580-584.
  36. Tay, I., S. Garland, A. Gorelik and J. D. Wark (2017). "Development and Testing of a Mobile Phone App for Self-Monitoring of Calcium Intake in Young Women." JMIR Mhealth Uhealth 5(3).
  37. Tropea, J., D. LoGiudice, D. Liew, A. Gorelik and C. Brand (2017). "Poorer outcomes and greater healthcare costs for hospitalised older people with dementia and delirium: a retrospective cohort study." Int J Geriatr Psychiatry 32(5): 539-547.
  38. Wallace, R., M. A. Anderson, K. See, A. Gorelik, L. Irving and R. Manser (2017). "Venous thromboembolism management practices and knowledge of guidelines: a survey of Australian haematologists and respiratory physicians." Intern Med J 47(4): 436-446.
  39. Waterworth, G., S. Wein, A. Gorelik and A. H. Rotstein (2017). "MRI assessment of calf injuries in Australian Football League players: findings that influence return to play." Skeletal Radiol 46(3): 343-350.
  40. Wong, E., K. Mason, J. Collins, B. Hockridge, J. Boyd, A. Gorelik, J. Szer and D. S. Ritchie (2017). "Prognostic Limitations of Donor T Cell Chimerism after Myeloablative Allogeneic Stem Cell Transplantation for Acute Myeloid Leukemia and Myelodysplastic Syndromes." Biol Blood Marrow Transplant 23(5): 840-844.