Clinical Trials

Project Details

1. SMARRT Study

An NHMRC funded multi-national prospective pharmacokinetic study, improving antibiotic dosing in renal replacement therapy for the five most commonly prescribed antibiotics Piperacillin-Tazobactam, Meropenem, Vancomycin and Imipenem and Linezolid at selected sites. In collaboration with Dr Jason Roberts of the Burns, Trauma & Critical Care Research Centre, Royal Brisbane & Women’s Hospital, QLD.

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2. TCZ Phase III

A phase III randomized study of humanized anti-IL-6 receptor antibody Tocilizumab (TCZ) to prevent development of acute graft versus host disease (GVHD) post HLA-matched allogeneic haematopoietic progenitor cell transplantation (HPCT). In collaboration with Royal Brisbane & Women’s Hospital and QIMR Berghofer Medical Research Institute. The study is supported by NHMRC and Roche.

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3. WBV for Osteoporosis Trial

An NHMRC-funded  double-blinded, block-randomised, placebo-controlled clinical trial investigating the effects of low intensity whole body vibration (LWBV) on risk factors for hip fracture in post-menopausal women. In collaboration with A/Prof. Belinda Beck, Centre for Musculoskeletal Research, Griffith University, Gold Coast, QLD.

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4. FOHX Trial

A prospective randomised single-blinded clinical trial in a community setting will evaluate the outcome of foot orthoses compared to hip strengthening exercises in people with patellofemoral pain.

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5. Phase 3 Trial in Diabetes

Double blind, randomized controlled multicentre clinical trial on efficacy and safety of "Zhongyi" Xiaoke Wan for diabetes mellitus. In collaboration with Prof. Linong Ji, Peking University People’s Hospital, Beijing, China.

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6. Telehealth in RACF Trial

An NHMRC-funded pragmatic randomised controlled trial aims to examine the effectiveness of telehealth to reduce utilisation of external health services by aged care residents in long term care. In collaboration with Dr Melinda Martin-Khan and Prof. Leonard Gray of the Centre for Research in Geriatric Medicine, School of Medicine, University of Queensland.

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7. BPRP Trial

The Beijing Pre-diabetes Reversion Programme (BPRP)  is a 3-year follow-up randomised controlled clinical trial in subjects with pre-diabetes. In collaboration with Prof. Linong Ji and Dr. Yingying Luo of Peking University.

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8. BLING II

An NHMRC-funded phase IIb randomised controlled trial of continuous beta-lactam infusion compared with intermittent beta-lactam dosing in critically ill patients (BLING II). In collaboration with Prof. Jeffrey Lipman and Dr Joel Dulhunty of the Burns, Trauma & Critical Care Research Centre, Royal Brisbane & Women’s Hospital, QLD.

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Research Group

Melbourne EpiCentre




Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Medicine and Radiology

Node

Royal Melbourne Hospital

Unit / Centre

Melbourne EpiCentre