Electrophysiological Properties of Human Brain Neuronal Tissue

Project Details

Almost all electrophysiological observations of neural normal function, drug responsiveness and abnormal states such as epilepsy in have been performed on rodent brain tissue. It is becoming clear, however, that human tissue has significant differences from rodent brain.

This project presents an almost unique opportunity to study human brain tissue at the single neuron and network level by utilising tissue taken in the course of neurosurgical procedures. Individual neurons are prepared by enzymatic dissociation, and recorded with patch electrodes. Network properties are recorded using intact brain slice.

For this project, the main aims are to identify the properties of voltage gated ion channels, in particular sodium and potassium currents. An area of special interest is the HERG channel subtype, which is likely to play an important role in brain function, but almost completely uncharacterised in any neural system.

Researchers

Collaborators

  • Dr Lucy Palmer (Florey)
  • Dr Gui Silva (ANU)

Research Group

Neural Dynamics Laboratory



Faculty Research Themes

Neuroscience

School Research Themes

Neuroscience & Psychiatry



Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Medicine and Radiology

Node

Royal Melbourne Hospital

Unit / Centre

Neural Dynamics Laboratory