Stroke Imaging and Treatment

Research Overview

This research group investigates the advanced imaging of ischemic stroke and intracerebral hemorrhage to improve diagnosis and identify patients likely to respond to treatments. We apply this imaging to clinical trials of new stroke treatments.

Collaborators

  • Stanford Stroke Center, California, USA - G Albers
  • John Hunter Hospital, University of Newcastle, NSW, Australia - M Parsons, C Levi.

Funding

  • NHMRC
  • Heart Foundation

Research Opportunities

This research project is available to PhD students to join as part of their thesis.
Please contact the Research Group Leader to discuss your options.

Research Publications

  • Goyal M, Menon BK, van Zwam WH, Dippel DWJ, Mitchell PJ, Demchuk A, Dávalos A, Majoie CBLM, van der Lugt A, de Miquel MA, Donnan GA, Roos YBWEM, Bonafe A, Jahan R, Diener HC, van den Berg LA, Levy EI, Berkhemer OA, Pereira VM, Rempel J, Millán M, Davis SM, Roy D, Thornton J, San Román L, Ribó M, Beumer D, Stouch BC, Brown S, Campbell BCV, van Oostenbrugge RJ, Saver JL, Hill MD, Jovin TG. Endovascular thrombectomy for large vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials. The Highly Effective Reperfusion evaluated in Multiple Endovascular Stroke Trials (HERMES) collaboration. Lancet 2016, 387:1723-31
  • Campbell BCV, Mitchell PJ, Kleinig TJ, Dewey HM, Churilov L, Yassi N, Yan B, Dowling RJ, Parsons MW, Oxley TJ, Wu TY, Brooks M, Simpson MA, Miteff F, Levi CR, Krause M, Harrington TJ, Faulder KC, Steinfort BS, Priglinger M, Ang T, Scroop R, Barber PA, McGuinness B, Wijeratne T, Phan TG, Chong W, Chandra RV, Bladin CF, Badve M, Rice H, de Villiers L, Ma H, Desmond PM, Donnan GA, Davis SM, on behalf of the EXTEND-IA investigators. Endovascular Therapy for Ischemic Stroke with Perfusion Imaging Selection. N Engl J Med 2015, 372:1009-1018
  • Campbell BCV, Yassi N, Ma H, Sharma G, Salinas S, Churilov L, Meretoja A, Parsons MW, Desmond PM, Lansberg M, Donnan GA, Davis SM. Imaging selection in ischemic stroke: feasibility of automated CT-perfusion analysis. Int J Stroke. 2015;10:51-54
  • Yassi N, Parsons MW, Christensen S, Sharma G, Bivard A, Donnan GA, Levi CR, Desmond PM, Davis SM, Campbell BCV. Prediction of post thrombolysis hemorrhage using CT perfusion. Stroke 2013, 44:3039-3043
  • Campbell BCV, Christensen S, Parsons MW, Churilov L, Desmond PM, Barber PA, Butcher K, Levi C, De Silva DA, Lansberg MG, Mlynash M, Straka M, Olivot JM, Bammer R, Albers GW, Donnan GA, Davis SM for the EPITHET-DEFUSE Investigators. Advanced Imaging Improves Prediction of Hemorrhage after Stroke Thrombolysis. Annals of Neurology. 2013, 73:510–519
  • Campbell BCV, Weir L, Desmond PM, Tu HTH, Hand PJ, Yan B, Donnan GA, Parsons MW, Davis SM. CT perfusion improves diagnostic accuracy and confidence in acute ischemic stroke. JNNP 2013;84:613-618
  • Campbell BCV, Christensen S, Levi C, Desmond P, Donnan G, Davis S, Parsons M. Comparison of CT Perfusion and MRI Perfusion-Diffusion mismatch in Ischemic Stroke. Stroke 2012, 43:2648-53
  • Campbell BCV, Tu H, Christensen S, Desmond PM, Levi CR, Bladin CF, Hjort N, Ashkanian M, Sølling C, Donnan GA, Davis SM, Østergaard L and Parsons MW. Assessing response to stroke thrombolysis: Validation of 24 hour multimodal MRI. Archives of Neurology 2012, 69:46-50
  • Campbell BCV, Purushotham A, Christensen S, Nagakane Y, Desmond PM, Parsons MW, Lansberg MG, Mlynash M, Straka M, De Silva DA, Olivot JM, Bammer R, Albers GW, Donnan GA, Davis SM for the EPITHET-DEFUSE Investigators. The infarct core is well represented by the acute diffusion lesion: sustained reversal is infrequent. J. Cerebral Blood Flow and Metabolism 2012, 32:50-6
  • Lansberg MG, Lee J, Christensen S, Straka M, De Silva DA, Mlynash M, Campbell BCV, Bammer R, Olivot JM, Desmond P, Davis SM, Donnan GA, Albers GW. RAPID Automated Patient Selection for Reperfusion Therapy: A Pooled Analysis of the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET) and the Diffusion and Perfusion Imaging Evaluation for Understanding Stroke Evolution (DEFUSE) study. Stroke 2011, 42:1608-14
  • Campbell BCV, Christensen S, Levi C, Desmond P, Donnan G, Davis S, Parsons M. Cerebral Blood Flow is the Optimal CT Perfusion Parameter For Assessing Infarct Core. Stroke 2011, 42:3435-40
  • Campbell BCV*, Chemmanam T*, Christensen S, Nagakane Y,  Desmond P, Bladin C, Parsons M, Levi C, Barber PA,   Donnan G, Davis S, EPITHET Investigators. Ischemic Diffusion Lesion Reversal is Uncommon and Rarely Alters Perfusion-Diffusion Mismatch. Neurology 2010, 75:1040-1047.  *Joint first authors

Research Projects



Faculty Research Themes

Neuroscience

School Research Themes

Neuroscience & Psychiatry



Key Contact

For further information about this research, please contact Associate Professor Bruce Campbell

Department / Centre

Medicine and Radiology

Unit / Centre

Stroke Imaging and Treatment