Patterns and impacts of antimicrobial usage in livestock

Project Details

While very large quantities of antimicrobials are administered to food producing animals, usage in animal production is generally restricted to specific registered classes of antimicrobials and administration is generally for restricted periods of time in relatively isolated populations of animals. In contrast, antimicrobial usage in companion animals (dogs, cats and horses) is across a wider range of classes, within less isolated populations and in animals in near constant contact with humans. While some of this usage may not result in increased risk of transfer of resistance into humans, other patterns of prescribing may have a high risk, but there is little information available about the approaches to usage that pose the greatest risk.  Any education of veterinary prescribers, or change in regulation of antimicrobial usage in veterinary practice, will depend on the acquisition of data to differentiate high-risk behaviour from that posing much lower risks. 

The data currently available about veterinary usage of antibiotics, as reported by the Australian Pesticides and Veterinary Medicines Authority (APVMA), is limited to the total tonnages of antimicrobials imported for veterinary purposes, with no differentiation of the distribution of these drugs to different animal species or production systems, and no information about the stage the animals’ lives when the drugs are administered. Administration for a short period of time to neonates is likely to have much less impact on transfer of resistance into the human food chain than administration over an extended period of time to older animals closer to the time of harvest.

The aim of the proposed studies will be to gain a clear understanding of the volumes of antimicrobials administered to different food animals, the specific antimicrobials used in typical herds and flocks and the distribution of this usage over the lifetime of these animals. The indications that serve as signals to prescribers will be explored to identify those that are justifiable and those that are questionable, and to identify health problems that might be the focus of alternative solutions. In addition, the rationale for specific choices of drug will be assessed and compared to the evidence available to support this use. This will further assist in identifying gaps in evidence for different prescribing patterns that can be addressed to guide improved behaviour.

Researchers

  • Professor Glenn Browning CI
  • Dr Helen Billman Jacobe AI

Funding

  • NHMRC CRE Grant APP1079625

Research Opportunities

This research project is available to PhD students to join as part of their thesis.
Please contact the Research Group Leader to discuss your options.

Research Group

The National Centre for Antimicrobial Stewardship (NCAS)


Research Themes

Infection and Immunity


Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Medicine and Radiology