Basic Musculoskeletal Biology

  • Group Leader

    Dr Jonathan Gooi
    T: +61 3 9288 2598
    E: jgooi@unimelb.edu.au
    Location: Level 3, Rm 309, Clinical Sciences Building, St Vincent's Hospital, 28 Regent Street Fitzroy
    W: Personal web page

Research Overview

Research in the Gooi lab is focused on examining the fundamental signalling mechanisms involved in musculoskeletal biology. Current projects are examining how osteocytes respond to mechanical loading and the mechanisms by which they control bone formation and bone resorption. Other projects include investigating the cross talk between skeletal muscle and bone cells.

Specific projects include:

  1. Investigating the mechanisms of osteocyte differentiation
  2. Determine how osteocytes perceive mechanical signals

Staff

  • Cale Dobrosak, Honours student
  • Victoria Baker, Honours student
  • Jie Yang, Honours student

Collaborators

  • Professor Jack Martin, St Vincent's Institute
  • Associate Professor Natalie Sims, St Vincent's Institute
  • Associate Professor Divieti-Pajevic, Boston University
  • Associate Professor Alan Hayes, Victoria University
  • Associate Professor John Price, Victoria University
  • Dr Julian Quinn, Garvan Institute of Medical Research

Funding

  • Melbourne Medical School
  • St Vincent's Hospital Research Endowment Fund

Research Opportunities

This research project is available to PhD students to join as part of their thesis.
Please contact the Research Group Leader to discuss your options.

Research Publications

  1. The Wnt Inhibitor Sclerostin Is Up-regulated by Mechanical Unloading in Osteocytes in Vitro.
    Spatz JM, Wein MN, Gooi JH, Qu Y, Garr JL, Liu S, Barry KJ, Uda Y, Lai F, Dedic C, Balcells-Camps M, Kronenberg HM, Babij P, Pajevic PD.
    J Biol Chem. 2015 Jul 3;290(27):16744-58. doi: 10.1074/jbc.M114.628313. Epub 2015 May 7.
  2. Decline in calcitonin receptor expression in osteocytes with age.
    Gooi JH, Chia LY, Walsh NC, Karsdal MA, Quinn JM, Martin TJ, Sims NA.
    J Endocrinol. 2014 Apr 22;221(2):181-91. doi: 10.1530/JOE-13-0524. Print 2014 May.
  3. Reversing LRP5-dependent osteoporosis and SOST deficiency-induced sclerosing bone disorders by altering WNT signaling activity.
    Chang MK, Kramer I, Keller H, Gooi JH, Collett C, Jenkins D, Ettenberg SA, Cong F, Halleux C, Kneissel M.
    J Bone Miner Res. 2014 Jan;29(1):29-42. doi: 10.1002/jbmr.2059.
  4. Calcitonin impairs the anabolic effect of PTH in young rats and stimulates expression of sclerostin by osteocytes.
    Gooi JH, Pompolo S, Karsdal MA, Kulkarni NH, Kalajzic I, McAhren SH, Han B, Onyia JE, Ho PW, Gillespie MT, Walsh NC, Chia LY, Quinn JM, Martin TJ, Sims NA.
    Bone. 2010 Jun;46(6):1486-97. doi: 10.1016/j.bone.2010.02.018. Epub 2010 Feb 24.
  5. Osteocyte Wnt/beta-catenin signaling is required for normal bone homeostasis.
    Kramer I, Halleux C, Keller H, Pegurri M, Gooi JH, Weber PB, Feng JQ, Bonewald LF, Kneissel M.
    Mol Cell Biol. 2010 Jun;30(12):3071-85. doi: 10.1128/MCB.01428-09. Epub 2010 Apr 19.
  6. Communication between ephrinB2 and EphB4 within the osteoblast lineage.
    Martin TJ, Allan EH, Ho PW, Gooi JH, Quinn JM, Gillespie MT, Krasnoperov V, Sims NA.
    Adv Exp Med Biol. 2010;658:51-60. doi: 10.1007/978-1-4419-1050-9_6.
  7. Molecular mechanisms in coupling of bone formation to resorption.
    Martin T, Gooi JH, Sims NA.
    Crit Rev Eukaryot Gene Expr. 2009;19(1):73-88.
  8. Bone remodeling: Multiple cellular interactions required for coupling of bone formation and resorption.
    Sims NA, Gooi JH.
    Semin Cell Dev Biol. 2008 Oct;19(5):444-51. doi: 10.1016/j.semcdb.2008.07.016. Epub 2008 Jul 31.

Research Projects

This Research Group doesn't currently have any projects


School Research Themes

Musculoskeletal



Key Contact

For further information about this research, please contact Dr Jonathan Gooi

Department / Centre

Medicine and Radiology

Unit / Centre

Basic Musculoskeletal Biology