Biomarker Discovery Group:Diagnostic biomarkers of pregnancy complications

Research Overview

The group is interested in the discovery and validation of putative biomarkers for the prediction of various pregnancy complications. Emphasis is on the early prediction of preterm labour, gestational diabetes, fetal growth restriction and preeclampsia. These pregancy complications are likely to have their origin in early pregnancy but pathology often becomes manifest in the third trimester. Proteomic technologies are used to identify and characterise putative biomarkers that may be used to assess risk of future pregnancy complications. These biomarkers can also serve to understand the pathogenesis of disease or serve as therapeutic targets  for early pregnancy intervention.

Staff

Collaborators

  • Dr Phillip Melton, University of Western Australia
  • Prof Greg Rice, University of Queensland
  • Dr Stella Liong, University of Melbourne
  • Dr Yujing Heng, Harvard University

Funding

Norman Beischer Medical Research Foundation

Research Opportunities

This research project is available to PhD students to join as part of their thesis.
Please contact the Research Group Leader to discuss your options.

Research Publications

Di Quinzio MKW, Oliva K, Holdsworth SJ, Ayhan M, Walker SP, Rice GE, Georgiou HM, Permezel M. Proteomic analysis and characterisation of human cervico-vaginal proteins. Aust. NZ. J. Obstet. Gynaecol. 47:9-15, 2007

Di Quinzio MKW, Georgiou HM, Holdsworth-Carson SJ, Ayhan M, Heng YJJ, Walker SP, Rice GE, Permezel M. Proteomic analysis of human cervico-vaginal fluid displays differential protein expression in association with labour onset at term. J. Proteome Res. 7:1916-1921, 2008

Heng YJ, Di Quinzio MKW, Permezel M, Rice GE, Georgiou HM. Interleukin-1 receptor antagonist in human cervico-vaginal fluid in term pregnancy and labour. Am. J. Obstet. Gynecol. 199:656.e1-656.e7, 2008

Hodges R, Salvador L, D’Antona D, Georgiou HM, Wallace EM. Activin A as a marker of intrauterine infection in women with preterm prelabour rupture of membranes. J. Perinatol. 30:22-26, 2010

Heng YJ, Di Quinzio MKW, Permezel M, Ayhan M, Rice GE, Georgiou HM. Temporal proteomic analysis of human cervicovaginal fluid with impending labour. J. Proteome Res. 9:1344-1350, 2010

Heng YJ, Di Quinzio MKW, Permezel M, Rice GE, Georgiou HM. Temporal expression of antioxidants in human cervicovaginal fluid associated with spontaneous labour. Antioxid. Redox Signal. 13:951-957, 2010

Heng YJ, Di Quinzio MKW, Permezel M, Rice GE, Georgiou HM. Cystatin A protease inhibitor and cysteine proteases in human cervicovaginal fluid in term pregnancy and labour. Am. J. Obstet. Gynecol. 204:254.e1-e7, 2011

Georgiou HM, Thio YS, Russell C, Permezel M, Heng YJ, Lee S, Tong S. Association between serum immune cytokine profiles at 7-10 weeks’ gestation and low birthweight. Am. J. Obstet. Gynecol. 204:415.e1-e12, 2011

Georgiou HM, Lopez SI, Rice GE. Novel screening approaches for the early detection of gestational diabetes mellitus. In “Gestational Diabetes” eds Radenkovic M, InTech Publishing, 2011. ISBN 978-953-307-359-0 (open access)

Heng YJ, Di Quinzio MKW, Liong S, Permezel M, Rice GE, Georgiou HM. Temporal investigation of matrix metalloproteinases and their inhibitors in human cervicovaginal fluid. Reprod. Sci. 19(1): 55-63, 2012

Liong S, Di Quinzio MKW, Heng YJ, Fleming G, Permezel M, Rice GE, Georgiou HM. Proteomic analysis of human cervicovaginal fluid collected prior to preterm premature rupture of the fetal membranes. Reproduction 145 (2):137-147, 2013

Liong S, Di Quinzio MKW, Fleming G, Permezel M, Rice GE, Georgiou HM. Prediction of spontaneous preterm labour in at-risk pregnant women. Reproduction 146 (4): 335-345, 2013

Liong S, Di Quinzio MKW, Fleming G, Permezel M, Georgiou HM. Is vitamin D binding protein a novel predictor of labour? PLOS One 8 (10): e76490, 2013 (open access)

Heng YJ, Liong S, Permezel M, Rice GE, Di Quinzio MKW, Georgiou HM. Predicting spontaneous term labour: The interplay of the IL-1 system. Reprod. Sci. 21 (1):122-130, 2014

Liong S, Di Quinzio MKW, Fleming G, Permezel M, Georgiou HM. New biomarkers for the prediction of spontaneous preterm labour in symptomatic pregnant women: a comparison with fetal fibronectin. BJOG 122:370-379, 2015

Peiris HN, Georgiou HM, Lappas M, Kaitu’ulino T, Salomon C, Vaswani K, Rice GE, Mitchell MD. Myostatin expression in intrauterine growth restriction and preeclampsia complicated pregnancies, and alterations to cytokine production of first trimester placental explants following myostatin treatment. Reprod Sci 22(10):1202-1211, 2015

Heng YJ, Liong S, Permezel M, Rice GE, Di Quinzio MKW, Georgiou HM. Biomarkers in human cervicovaginal fluid to predict labour. Biomarkers for gynaecological pathologies and their appearance in cervicovaginal fluid. Editors: Van Ostade X, Verhelst R. Publisher: Frontiers in Physiology 6:151, 2015 (open access)

Georgiou HM, Di Quinzio MKW, Permezel M, Brennecke SP. Predicting Preterm Labour: Current Status and Future Prospects. Disease Markers vol 2015, Article ID 435014, 9 pages, 2015. doi:10.1155/2015/435014 (open access)

Research Projects

This Research Group doesn't currently have any projects



Faculty Research Themes

Child Health

School Research Themes

Child Health in Medicine



Key Contact

For further information about this research, please contact Harry Georgiou

Department / Centre

Obstetrics and Gynaecology

Unit / Centre

Biomarker Discovery Group:Diagnostic biomarkers of pregnancy complications