Gynaecology Research Centre - Rogers Group
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Professor Women's Health Research
Professor Peter Rogers+61 3 8345 3706
Research Overview
The Gynaecology Research Centre, based in the Royal Women's Hospital, is the first centre in Australia to bring together clinical and laboratory expertise to investigate a wide range of common gynaecological issues. These health conditions include: adverse menopausal symptoms, managing menopause after cancer, heavy and abnormal menstrual bleeding; endometriosis, uterine fibroids, pelvic pain, infertility and sexual health dysfunction due to cancer treatment.
The Rogers group has a strong focus on discovery: In particular understanding the mechanisms underlying common problems such as endometriosis, heavy menstrual bleeding and fibroids. They have created the largest biobank of endometriosis samples in the world with attached genotyping, expression data, clinical and other phenotypic data.
Staff
- Prof Peter Rogers – Research Director at the Women’s
- Dr Jacqueline Donoghue - Research Fellow
- Dr Charlotte Reddington - Clinical Senior Research Fellow
- Dr Vanessa Ross - Clinical Senior Research Fellow
- Leonie Cann – Research Assistant
- Georgie Prewer - Research Assistant
- Brodie Bilston – Research Assistant
- Dr Genia Rozen - PhD Student
- Jessica Chung - PhD Student
- Keryn Harlow - PhD Student
- Dr Samantha Mooney - PhD Student
Current PhD opportunities -
More information for PhD opportunities here.
Collaborators
- Royal Women’s Hospital
- Mercy Hospital for Women
- Julia Argyrou Endometriosis Centre, Epworth HealthCare
- Melbourne Bioinformatics
- Monash University
- University of Otago
- Murdoch University
- University of Queensland
- RMIT
- Melbourne IVF
- Victorian Centre for Functional Genomics
- University of Western Australia
- University of NSW
- University of Sydney
- Harvard University
- Cambridge University
- Oxford University
- University of Washington at St Louis
- University of Washington State
- MD Anderson Cancer Centre
- Edinburgh University
Funding
This research has been funded by the National Health and Medical Research Council (NHMRC) and the Medical Research Future Fund (MRFF).
Research Opportunities
This research project is available to PhD students to join as part of their thesis.
Please contact the Research Group Leader to discuss your options.
Research Publications
Superficial peritoneal endometriotic lesion are histologically diverse and rarely demonstrate menstrual cycle synchronicity with matched eutopic endometrium. E M Colgrave, S Bittinger, M Healey, U P Dior, P A W Rogers, J R Keast, J E Girling, S J Holdsworth-Carson. Human Reproduction. deaa249, https://doi.org/10.1093/humrep/deaa249. Epub 2020 November 5.
Obesity does not alter endometrial gene expression in women with endometriosis. Holdsworth-Carson SJ, Chung J, Sloggett C, Mortlock S, Fung JN, Montgomery GW, Dior UP, Healey M, Rogers PA, Girling JE.Reprod Biomed Online. 2020 Jul;41(1):113-118. doi: 10.1016/j.rbmo.2020.03.015. Epub 2020 May 3.
Tissue specific regulation of transcription in endometrium and association with disease. Mortlock S, Kendarsari RI, Fung JN, Gibson G, Yang F, Restuadi R, Girling JE, Holdsworth-Carson SJ, Teh WT, Lukowski SW, Healey M, Qi T, Rogers PAW, Yang J, McKinnon B, Montgomery GW.Hum Reprod. 2020 Feb 29;35(2):377-393. doi: 10.1093/humrep/dez279.
Endometrial uNK cell counts do not predict successful implantation in an IVF population. Donoghue JF, Paiva P, Teh WT, Cann LM, Nowell C, Rees H, Bittinger S, Obers V, Bulmer JN, Stern C, McBain J, Rogers PAW.Hum Reprod. 2019 Dec 1;34(12):2456-2466. doi: 10.1093/humrep/dez194
Genetic regulation of methylation in human endometrium and blood and gene targets for reproductive diseases. Mortlock S, Restuadi R, Levien R, Girling JE, Holdsworth-Carson SJ, Healey M, Zhu Z, Qi T, Wu Y, Lukowski SW, Rogers PAW, Yang J, McRae AF, Fung JN, Montgomery GW.Clin Epigenetics. 2019 Mar 14;11(1):49. doi: 10.1186/s13148-019-0648-7.
Generation of immortalized human endometrial stromal cell lines with different endometriosis risk genotypes. Holdsworth-Carson SJ, Colgrave EM, Donoghue JF, Fung JN, Churchill ML, Mortlock S, Paiva P, Healey M, Montgomery GW, Girling JE, Rogers PAW.Mol Hum Reprod. 2019 Apr 1;25(4):194-205. doi: 10.1093/molehr/gaz006.
The Association of Sonographic Evidence of Adenomyosis with Severe Endometriosis and Gene Expression in Eutopic Endometrium. Dior UP, Nisbet D, Fung JN, Foster G, Healey M, Montgomery GW, Rogers PAW, Holdsworth-Carson SJ, Girling JE.J Minim Invasive Gynecol. 2019 Jul-Aug;26(5):941-948. doi: 10.1016/j.jmig.2018.09.780. Epub 2018 Sep 28.
Identification of nine new susceptibility loci for endometrial cancer. O'Mara TA, et al.Nat Commun. 2018 Aug 9;9(1):3166. doi: 10.1038/s41467-018-05427-7.
Genetic regulation of disease risk and endometrial gene expression highlights potential target genes for endometriosis and polycystic ovarian syndrome. Fung JN, Mortlock S, Girling JE, Holdsworth-Carson SJ, Teh WT, Zhu Z, Lukowski SW, McKinnon BD, McRae A, Yang J, Healey M, Powell JE, Rogers PAW, Montgomery GW.Sci Rep. 2018 Jul 30;8(1):11424. doi: 10.1038/s41598-018-29462-y.
The genetic regulation of transcription in human endometrial tissue. Fung JN, Girling JE, Lukowski SW, Sapkota Y, Wallace L, Holdsworth-Carson SJ, Henders AK, Healey M, Rogers PAW, Powell JE, Montgomery GW.Hum Reprod. 2017 Apr 1;32(4):893-904. doi: 10.1093/humrep/dex006.
Research Priorities for Endometriosis.
Rogers PA, Adamson GD, Al-Jefout M, Becker CM, D'Hooghe TM, Dunselman GA, Fazleabas A, Giudice LC, Horne AW, Hull ML, Hummelshoj L, Missmer SA, Montgomery GW, Stratton P, Taylor RN, Rombauts L, Saunders PT, Vincent K, Zondervan KT; WES/WERF Consortium for Research Priorities in Endometriosis.Reprod Sci. 2017 Feb;24(2):202-226. doi: 10.1177/1933719116654991. Epub 2016 Sep 27.
Differential Gene Expression in Menstrual Endometrium From Women With Self-Reported Heavy Menstrual Bleeding. Girling JE, Lockhart MG, Olshansky M, Paiva P, Woodrow N, Marino JL, Hickey M, Rogers PAW.Reprod Sci. 2017 Jan;24(1):28-46. doi: 10.1177/1933719116648217. Epub 2016 Sep 27.PMID: 27189201
Endometriosis risk alleles at 1p36.12 act through inverse regulation of CDC42 and LINC00339. Powell JE, Fung JN, Shakhbazov K, Sapkota Y, Cloonan N, Hemani G, Hillman KM, Kaufmann S, Luong HT, Bowdler L, Painter JN, Holdsworth-Carson SJ, Visscher PM, Dinger ME, Healey M, Nyholt DR, French JD, Edwards SL, Rogers PA, Montgomery GW.Hum Mol Genet. 2016 Nov 15;25(22):5046-5058. doi: 10.1093/hmg/ddw320.
Identification of genes differentially expressed in menstrual breakdown and repair. Paiva P, Lockhart MG, Girling JE, Olshansky M, Woodrow N, Marino JL, Hickey M, Rogers PA.Mol Hum Reprod. 2016 Dec;22(12):898-912. doi: 10.1093/molehr/gaw060. Epub 2016 Sep 8.
Differences in the cellular composition of small versus large uterine fibroids. Holdsworth-Carson SJ, Zhao D, Cann L, Bittinger S, Nowell CJ, Rogers PA.Reproduction. 2016 Nov;152(5):467-80. doi: 10.1530/REP-16-0216. Epub 2016 Aug 15.
Endometrial vezatin and its association with endometriosis risk. Holdsworth-Carson SJ, Fung JN, Luong HT, Sapkota Y, Bowdler LM, Wallace L, Teh WT, Powell JE, Girling JE, Healey M, Montgomery GW, Rogers PA. Hum Reprod. 2016 Mar 22. pii: dew047.
Relaxin deficiency results in increased expression of angiogenesis- and remodelling-related genes in the uterus of early pregnant mice but does not affect endometrial angiogenesis prior to implantation.
Marshall SA, Ng L, Unemori EN, Girling JE, Parry LJ. Reprod Biol Endocrinol. 2016 Mar 22;14(1):11.
Relaxin deficiency attenuates pregnancy-induced adaptation of the mesenteric artery to angiotensin II in mice. Marshall SA, Leo CH, Senadheera SN, Girling JE, Tare M, Parry LJ.
Am J Physiol Regul Integr Comp Physiol. 2016 Mar 2:ajpregu.00506.2015.
Relaxin deficiency attenuates pregnancy-induced adaptation of the mesenteric artery to angiotensin II in mice. Marshall SA, Leo CH, Senadheera SN, Girling JE, Tare M, Parry LJ.
Am J Physiol Regul Integr Comp Physiol. 2016 Mar 2:ajpregu.00506.2015.
Functional evaluation of genetic variants associated with endometriosis near GREB1.
Fung JN, Holdsworth-Carson SJ, Sapkota Y, Zhao ZZ, Jones L, Girling JE, Paiva P, Healey M, Nyholt DR, Rogers PA, Montgomery GW. Hum Reprod. 2015 May;30(5):1263-75.
Identifying the biological basis of GWAS hits for endometriosis. Fung JN, Rogers PA, Montgomery GW. Biol Reprod. 2015 Apr;92(4):87.
World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonization Project: II. Clinical and covariate phenotype data collection in endometriosis research. Vitonis AF, Vincent K, Rahmioglu N, Fassbender A, Buck Louis GM, Hummelshoj L, Giudice LC, Stratton P, Adamson GD, Becker CM, Zondervan KT, Missmer SA; WERF EPHect Working Group.
Fertil Steril. 2014 Nov;102(5):1223-32.
Common fibroid-associated genes are differentially expressed in phenotypically dissimilar cell populations isolated from within human fibroids and myometrium. Holdsworth-Carson SJ, Zaitseva M, Girling JE, Vollenhoven BJ, Rogers PA. Reproduction. 2014 Apr 8;147(5):683-92
Follistatin is essential for normal postnatal development and function of mouse oviduct and uterus.
Holdsworth-Carson SJ, Craythorn RG, Winnall WR, Dhaliwal K, Genovese R, Nowell CJ, Rogers PA, de Kretser DM, Hedger MP, Girling JE. Reprod Fertil Dev. 2014 Mar 17.
Clonality of smooth muscle and fibroblast cell populations isolated from human fibroid and myometrial tissues. Holdsworth-Carson SJ, Zaitseva M, Vollenhoven BJ, Rogers PA.
Mol Hum Reprod. 2014 Mar;20(3):250-9.
Enhanced uterine artery stiffness in aged pregnant relaxin mutant mice is reversed with exogenous relaxin treatment. Gooi JH, Richardson ML, Jelinic M, Girling JE, Wlodek ME, Tare M, Parry LJ.
Biol Reprod. 2013 Jul 25;89(1):18.
Corin, an enzyme with a putative role in spiral artery remodeling, is up-regulated in late secretory endometrium and first trimester decidua.
Kaitu'u-Lino TJ, Ye L, Tuohey L, Dimitriadis E, Bulmer J, Rogers P, Menkhorst E, Van Sinderen M, Girling JE, Hannan N, Tong S. Hum Reprod. 2013 May;28(5):1172-80.
Aberrant expression and regulation of NR2F2 and CTNNB1 in uterine fibroids.
Zaitseva M, Holdsworth-Carson SJ, Waldrip L, Nevzorova J, Martelotto L, Vollenhoven BJ, Rogers PA.
Reproduction. 2013 Jun 27;146(2):91-102.
Is fibroid heterogeneity a significant issue for clinicians and researchers?
Zhao D, Rogers PA. Reprod Biomed Online. 2013 Jul;27(1):64-74.
Defining future directions for endometriosis research: workshop report from the 2011 World Congress of Endometriosis In Montpellier, France. Rogers PA, D'Hooghe TM, Fazleabas A, Giudice LC, Montgomery GW, Petraglia F, Taylor RN. Reprod Sci. 2013 May;20(5):483-99. Epub 2013 Feb 20.
Expression patterns of activin, inhibin and follistatin variants in the adult male mouse reproductive tract suggest important roles in the epididymis and vas deferens. Winnall WR, Wu H, Sarraj MA, Rogers PA, de Kretser DM, Girling JE, Hedger MP. Reprod Fertil Dev. 2013;25(3):570-80.
The endometrial lymphatic vasculature: function and dysfunction.
Girling JE, Rogers PA. Rev Endocr Metab Disord. 2012 Dec;13(4):265-75.
Identification of label-retaining perivascular cells in a mouse model of endometrial decidualization, breakdown, and repair. Kaitu'u-Lino TJ, Ye L, Salamonsen LA, Girling JE, Gargett CE. Biol Reprod. 2012 Jun 22;86(6):184.
Fibroid-associated heavy menstrual bleeding: correlation between clinical features, Doppler ultrasound assessment of vasculature, and tissue gene expression profiles. Tsiligiannis SE, Zaitseva M, Coombs PR, Shekleton P, Olshansky M, Hickey M, Vollenhoven B, Rogers PA. Reprod Sci. 2013 Apr;20(4):361-70.
Dilated thin-walled blood and lymphatic vessels in human endometrium: a potential role for VEGF-D in progestin-induced break-through bleeding. Donoghue JF, McGavigan CJ, Lederman FL, Cann LM, Fu L, Dimitriadis E, Girling JE, Rogers PA. PLoS One. 2012;7(2):e30916.
Progesterone stimulates expression of follistatin splice variants Fst288 and Fst315 in the mouse uterus.
Craythorn RG, Winnall WR, Lederman F, Gold EJ, O'Connor AE, de Kretser DM, Hedger MP, Rogers PA, Girling JE. Reprod Biomed Online. 2012 Mar;24(3):364-74.