Gynaecology Research Centre

Research Overview

The Research focus of the gynaecology research centre covers several areas:

Healthy ageing in women, particularly after a cancer diagnosis. This includes both physical and mental health.

The early life origins of reproductive health in women.

The Gynaecology Research Centre has a strong focus on discovery: In particular understanding the mechanisms underlying common problems in women’s health such as heavy menstrual bleeding, endometriosis and fibroids.

  • World leaders in management of menopause after cancer: growing population of cancer survivors
  • Largest biobank of endometriosis samples in the world with attached genotyping, expression data, clinical and other phenotypic data
  • Studies of the genetic mechanisms that confer susceptibility to endometriosis is world-leading

The Gynaecology Research Centre, based in the Royal Women's Hospital, is the first centre in Australia to bring together clinical and laboratory expertise to investigate a wide range of common gynaecological issues. These health conditions include: adverse menopausal symptoms, managing menopause after cancer, heavy and abnormal menstrual bleeding; endometriosis, uterine fibroids, pelvic pain, infertility and sexual health dysfunction due to cancer treatment.

Staff

Collaborators

  • University of Queensland
  • University of Western Australia
  • University of NSW
  • University of Sydney
  • Harvard University
  • Cambridge University
  • Oxford University
  • University of Washington at St Louis
  • University of Washington State
  • MD Anderson Cancer centre
  • Edinburgh University
  • Prof Grant Montgomery, University of Queensland
  • Prof Janet Keast, Department of Anatomy and Neuroscience, University of Melbourne
  • Assoc Prof Beverley Vollenhoven, Department of Obstetrics and Gynaecology, Monash University
  • Assoc Prof Martin Healey, Royal Women's Hospital
  • Dr Uri Dior, Royal Women's Hospital
  • Dr Andrew Dobrotwir, Royal Women's Hospital
  • Dr Andrew Webb, WEHI
  • Assoc Prof Jeffrey Crosbie, RMIT
  • Mr Cameron Nowell, Monash University

Funding

NHMRC Project Grant: (PA Rogers, G Montgomery, JE Girling) Identification and function of genes that increase risk for endometriosis.

JN Peters Bequest Fellowship, The University of Melbourne, Dr Sarah Holdsworth-Carson

Research Publications

Endometrial vezatin and its association with endometriosis risk.
Holdsworth-Carson SJ, Fung JN, Luong HT, Sapkota Y, Bowdler LM, Wallace L, Teh WT, Powell JE, Girling JE, Healey M, Montgomery GW, Rogers PA.
Hum Reprod. 2016 Mar 22. pii: dew047. [Epub ahead of print]

Relaxin deficiency results in increased expression of angiogenesis- and remodelling-related genes in the uterus of early pregnant mice but does not affect endometrial angiogenesis prior to implantation.
Marshall SA, Ng L, Unemori EN, Girling JE, Parry LJ.
Reprod Biol Endocrinol. 2016 Mar 22;14(1):11.

Relaxin deficiency attenuates pregnancy-induced adaptation of the mesenteric artery to angiotensin II in mice.
Marshall SA, Leo CH, Senadheera SN, Girling JE, Tare M, Parry LJ.
Am J Physiol Regul Integr Comp Physiol. 2016 Mar 2:ajpregu.00506.2015. [Epub ahead of print]

An evaluation of novel real-time technology as a tool for measurement of radiobiological and radiation-induced bystander effects.
Ibahim MJ, Crosbie JC, Paiva P, Yang Y, Zaitseva M, Rogers PA.
Radiat Environ Biophys. 2016 Mar 19. [Epub ahead of print]

The normal tissue effects of microbeam radiotherapy: What do we know, and what do we need to know to plan a human clinical trial?
Smyth LM, Senthi S, Crosbie JC, Rogers PA.
Int J Radiat Biol. 2016 Mar 16:1-10. [Epub ahead of print]

Image guidance protocol for synchrotron microbeam radiation therapy.
Pelliccia D, Poole CM, Livingstone J, Stevenson AW, Smyth LM, Rogers PA, Ha├╝sermann D, Crosbie JC.
J Synchrotron Radiat. 2016 Mar;23(2):566-73. doi: 10.1107/S1600577515022894. Epub 2016 Jan 28.

Eosinophil-Associated Gene Pathways but not Eosinophil Numbers are Differentially Regulated between Synchrotron Microbeam Radiation Treatment and Synchrotron Broad-Beam Treatment by 48 Hours Postirradiation.
Ibahim MJ, Yang Y, Crosbie JC, Stevenson A, Cann L, Paiva P, Rogers PA.
Radiat Res. 2016 Jan;185(1):60-8.

Relaxin deficiency attenuates pregnancy-induced adaptation of the mesenteric artery to angiotensin II in mice.
Marshall SA, Leo CH, Senadheera SN, Girling JE, Tare M, Parry LJ.
Am J Physiol Regul Integr Comp Physiol. 2016 Mar 2:ajpregu.00506.2015. [Epub ahead of print]

Functional evaluation of genetic variants associated with endometriosis near GREB1.
Fung JN, Holdsworth-Carson SJ, Sapkota Y, Zhao ZZ, Jones L, Girling JE, Paiva P, Healey M, Nyholt DR, Rogers PA, Montgomery GW.
Hum Reprod. 2015 May;30(5):1263-75.

Identifying the biological basis of GWAS hits for endometriosis.
Fung JN, Rogers PA, Montgomery GW.
Biol Reprod. 2015 Apr;92(4):87.

In vitro study of genes and molecular pathways differentially regulated by synchrotron microbeam radiotherapy.
Yang Y, Crosbie JC, Paiva P, Ibahim M, Stevenson A, Rogers PA.
Radiat Res. 2014 Dec;182(6):626-39.

World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonization Project: II. Clinical and covariate phenotype data collection in endometriosis research.
Vitonis AF, Vincent K, Rahmioglu N, Fassbender A, Buck Louis GM, Hummelshoj L, Giudice LC, Stratton P, Adamson GD, Becker CM, Zondervan KT, Missmer SA; WERF EPHect Working Group.
Fertil Steril. 2014 Nov;102(5):1223-32.

An evaluation of dose equivalence between synchrotron microbeam radiation therapy and conventional broad beam radiation using clonogenic and cell impedance assays.
Ibahim MJ, Crosbie JC, Yang Y, Zaitseva M, Stevenson AW, Rogers PA, Paiva P.
PLoS One. 2014 Jun 19;9(6):e100547.

Common fibroid-associated genes are differentially expressed in phenotypically dissimilar cell populations isolated from within human fibroids and myometrium.
Holdsworth-Carson SJ, Zaitseva M, Girling JE, Vollenhoven BJ, Rogers PA.
Reproduction. 2014 Apr 8;147(5):683-92

Follistatin is essential for normal postnatal development and function of mouse oviduct and uterus.
Holdsworth-Carson SJ, Craythorn RG, Winnall WR, Dhaliwal K, Genovese R, Nowell CJ, Rogers PA, de Kretser DM, Hedger MP, Girling JE.
Reprod Fertil Dev. 2014 Mar 17.

Clonality of smooth muscle and fibroblast cell populations isolated from human fibroid and myometrial tissues.
Holdsworth-Carson SJ, Zaitseva M, Vollenhoven BJ, Rogers PA.
Mol Hum Reprod. 2014 Mar;20(3):250-9.

Enhanced uterine artery stiffness in aged pregnant relaxin mutant mice is reversed with exogenous relaxin treatment.
Gooi JH, Richardson ML, Jelinic M, Girling JE, Wlodek ME, Tare M, Parry LJ.
Biol Reprod. 2013 Jul 25;89(1):18.

Corin, an enzyme with a putative role in spiral artery remodeling, is up-regulated in late secretory endometrium and first trimester decidua.
Kaitu'u-Lino TJ, Ye L, Tuohey L, Dimitriadis E, Bulmer J, Rogers P, Menkhorst E, Van Sinderen M, Girling JE, Hannan N, Tong S.
Hum Reprod. 2013 May;28(5):1172-80.

Reference dosimetry at the Australian Synchrotron's imaging and medical beamline using free-air ionization chamber measurements and theoretical predictions of air kerma rate and half value layer.
Crosbie JC, Rogers PA, Stevenson AW, Hall CJ, Lye JE, Nordstr├Âm T, Midgley SM, Lewis RA.
Med Phys. 2013 Jun;40(6):062103.

Aberrant expression and regulation of NR2F2 and CTNNB1 in uterine fibroids.
Zaitseva M, Holdsworth-Carson SJ, Waldrip L, Nevzorova J, Martelotto L, Vollenhoven BJ, Rogers PA.
Reproduction. 2013 Jun 27;146(2):91-102.

Is fibroid heterogeneity a significant issue for clinicians and researchers?
Zhao D, Rogers PA.
Reprod Biomed Online. 2013 Jul;27(1):64-74.

Defining future directions for endometriosis research: workshop report from the 2011 World Congress of Endometriosis In Montpellier, France.
Rogers PA, D'Hooghe TM, Fazleabas A, Giudice LC, Montgomery GW, Petraglia F, Taylor RN.
Reprod Sci. 2013 May;20(5):483-99. Epub 2013 Feb 20.

Expression patterns of activin, inhibin and follistatin variants in the adult male mouse reproductive tract suggest important roles in the epididymis and vas deferens.
Winnall WR, Wu H, Sarraj MA, Rogers PA, de Kretser DM, Girling JE, Hedger MP.
Reprod Fertil Dev. 2013;25(3):570-80.

The endometrial lymphatic vasculature: function and dysfunction.
Girling JE, Rogers PA.
Rev Endocr Metab Disord. 2012 Dec;13(4):265-75.

Identification of label-retaining perivascular cells in a mouse model of endometrial decidualization, breakdown, and repair.
Kaitu'u-Lino TJ, Ye L, Salamonsen LA, Girling JE, Gargett CE.
Biol Reprod. 2012 Jun 22;86(6):184.

Fibroid-associated heavy menstrual bleeding: correlation between clinical features, Doppler ultrasound assessment of vasculature, and tissue gene expression profiles.
Tsiligiannis SE, Zaitseva M, Coombs PR, Shekleton P, Olshansky M, Hickey M, Vollenhoven B, Rogers PA.
Reprod Sci. 2013 Apr;20(4):361-70.

Genome-wide transcription responses to synchrotron microbeam radiotherapy.
Sprung CN, Yang Y, Forrester HB, Li J, Zaitseva M, Cann L, Restall T, Anderson RL, Crosbie JC, Rogers PA.
Radiat Res. 2012 Oct;178(4):249-59.

Microbeam-irradiated tumour tissue possesses a different infrared absorbance profile compared to broad beam and sham-irradiated tissue.
Sharma M, Crosbie JC, Puskar L, Rogers PA.
Int J Radiat Biol. 2013 Feb;89(2):79-87.

Dilated thin-walled blood and lymphatic vessels in human endometrium: a potential role for VEGF-D in progestin-induced break-through bleeding.
Donoghue JF, McGavigan CJ, Lederman FL, Cann LM, Fu L, Dimitriadis E, Girling JE, Rogers PA.
PLoS One. 2012;7(2):e30916.

Progesterone stimulates expression of follistatin splice variants Fst288 and Fst315 in the mouse uterus.
Craythorn RG, Winnall WR, Lederman F, Gold EJ, O'Connor AE, de Kretser DM, Hedger MP, Rogers PA, Girling JE.
Reprod Biomed Online. 2012 Mar;24(3):364-74.

In situ biological dose mapping estimates the radiation burden delivered to 'spared' tissue between synchrotron X-ray microbeam radiotherapy tracks.
Rothkamm K, Crosbie JC, Daley F, Bourne S, Barber PR, Vojnovic B, Cann L, Rogers PA.
PLoS One. 2012;7(1):e29853.

Biodosimetric quantification of short-term synchrotron microbeam versus broad-beam radiation damage to mouse skin using a dermatopathological scoring system.
Priyadarshika RC, Crosbie JC, Kumar B, Rogers PA.
Br J Radiol. 2011 Sep;84(1005):833-42.