Arthritis Research Group
The goal of the Arthritis Research Group is to understand the complex interactions between cartilage cells and their matrix in both healthy cartilage and arthritic diseases. The Group focuses on the structure and function of the major cartilage molecules and the enzymes that destroy them in arthritic disease.
Research Group Leader: Professor Amanda Fosang
Australian Temperament Project Generation 3 Study
The Australian Temperament Project (ATP) is one of Australia’s oldest longitudinal studies of social-emotional development that has followed a representative sample of over 2000 infants and their parents from 4 months (1983) to over 30 years of age.
Research Group Leader: Professor Craig Olsson
Autism Research Team
With a focus on children and young people we are exploring possible genetic and epigenetic causes of subgroups of children with autism, as well as working toward understanding the prognosis, diagnosis, and best interventions. We are also working to understand mental health issues, participation and quality of life of children and young people living with autism, and their families.
Research Group Leader: Professor Katrina Williams
- Discovering differences and similarities between phenotype and biology of twins with autism and children with known genetic problems with a high risk of autism
- Gender differences in autism
- Incidence, prevalence and risk factors for autism. What can we learn from databases and existing administrative data?
- Understanding the outcomes, including their language, participation and quality of life, of children with autism
- Undestanding trajectories and biological underpinnings of children with autism who lose skills
- Using systematic reviews to understand prognosis, diagnosis and effective interventions for children with neurodevelopmental difference and disability
Centre for International Child Health
The Centre for International Child Health (CICH) was established in 2001 within the University of Melbourne's Department of Paediatrics and the Royal Children's Hospital. CICH is a World Health Organization Collaborating Centre for Research & Training in Child & Neonatal Health, and works closely with WHO, and child health institutions especially in Asia and the Pacific Region. CICH is involved in basic, field and clinical research, epidemiology, child health policy, training and education.
Research Group Leader: Professor Trevor Duke
Cerebral Palsy Research
Our research program has two aims: 1) to gain an improved understanding of the risk factors and causes of cerebral palsy with the ultimate goal of preventing some cases, and 2) to determine the optimal interventions (therapy, medications, surgery) for them. The ultimate goal is to improve outcomes, participation and quality of life for children with cerebral palsy and their families.
Research Group Leader: Professor Dinah Reddihough
- A program of research into dyskinesia in children with cerberal palsy
- Exploring the use of stem cells in cerebral palsy
- Improving understanding of MRI patterns, structure-function relationships and causal pathways in cerebral palsy
- Investigating and interpreting the use, costs, accessibility and organisation of healthcare services among children with cerebral palsy
- The Centre of Research Excellence in Cerebral Palsy (CRE-CP)
- The Victorian Cerebral Palsy Register (VCPR)
Genetics Education and Health Research
The Genetics Education and Health Research team explores and evaluates the provision and impact of genomic technologies and genetic services, as well as contributing to the development of educational programs. The research aims to promote understanding of genetics and genomics, and inform evidence-based practice, among families, health professionals and the community.
Research Group Leader: Professor Sylvia Metcalfe
Hugh Williamson Gait Laboratory/Orthopaedic Department
The group in the Hugh Williamson Gait Laboratory are involved in a series of interconnected studies including gait biomechanics, outcome studies and international collaborations.
Research Group Leader: Professor Kerr Graham
- A computer-aided decision system for gait analysis
- Is muscle surgery or bone surgery better for young children with cerebral palsy who have hip displacement? The Cerebral Palsy Hip Interventions Project (CP-HIP)
- Outcomes of Hip Interventions for Children with Cerebral Palsy – An International, Multi-Centre Prospective, Comparative Cohort Study
- Single Event Multilevel Surgery in Bilateral Spastic Cerebral Palsy: A Multi-centre, Long-term, Follow-up Study
- The Gait Outcomes Assessment List (GOAL): Validation of a new measure of gait function for children with cerebral palsy
- Understanding the effect of lower limb torsional deformities in typically developing children and adolescents
Infectious Diseases Group
The research of the Infectious Diseases Group focuses on improving the diagnosis, treatment and prevention of infectious diseases in children. It comprises both clinical and laboratory-based research studies. The clinical research aspect includes randomised controlled trials, observational studies and systematic reviews of best practice. Our laboratory research encompasses basic and applied medical microbiology, as well as immunological studies to explore the mechanisms by which pathogens cause disease and their interaction with the host immune response.
Research Group Leader: Professor Nigel Curtis
Intestinal Failure and Clinical Nutrition Group
The most common cause of death in patients with short bowel syndrome is sepsis in the setting of severe intestinal failure-associated liver disease.Liver disease occurs in ~65% of infants requiring long-term parenteral nutrition therapy following small bowel resection and is the cause of death in 3-19% of SBS infants. However, despite this, the cause and the complex mechanisms underlying the development of IFALD are poorly understood.
Research Group Leader: Professor Julie Bines
Kidney Development, Disease and Regeneration
Around 10-20% of kidney disease is inherited. In children with kidney disease, this is closer to 50% although in many instances, the disease-causing mutation is unknown, therefore limiting treatment options. In our research group, we investigate the genes required for normal kidney development and what happens as a result of genetic or environmental damage during development.
Research Group Leader: Professor Melissa Little
Murdoch Children’s Research Institute Genetics of Neurodisability
The Genetics of Neurodisability Group aims to improve the lives of children with neurodisability through improved diagnosis and treatment. The majority of neurodisabilities have a genetic cause, yet even using the latest genetic testing technologies, a specific cause is identified in only 25% of affected children.
Research Group Leader: Professor David Amor
Neurodevelopmental Genomics Research
The Neurodevelopmental Genomics Research Group is dedicated to identifying disease genes that affect the normal development and function of the brain and neuronal cells. By studying the functions of these genes we hope to gain a better understanding of the biology of these neurodevelopmental disorders.
Research Group Leader: Professor John Christodoulou
Rotavirus Group and Enteric Virus Group
The Rotavirus Group has contributed to the understanding of the safety of rotavirus vaccines, in particular Intussusception. The Group were responsible for leading the development of the Brighton Collaboration clinical case definition for intussusception and the validation of the use of this tools for large scale clinical trials of rotavirus vaccines and post-licensure surveillance actvities. The Enteric Virus Group hosts the Australian Rotavirus Surveillance Network and the WHO Asia-Pacific Regional Reference Laboratory.
Research Group Leader: Professor Julie Bines
Surgical Research Group
The Surgical Research Group works on a number of surgical problems affecting children, including: normal and abnormal descent of the testis, normal and abnormal postnatal germ cell development, the causes of intractable chronic constipation, the cause of duodenal atresia, novel treatments of colorectal disorders, and using state-of-the-art manometry to understand surgical problems in the gut.
Research Group Leader: Professor John M Hutson AO
- A mouse model of duodenal atresia
- Manometric studies on oesophageal atresia and colorectal disorders
- Novel investigations and treatments for intractable, chronic constipation
- Novel treatments for colorectal disorders
- Postnatal germ cells are controlled by FSH during ‘minipuberty’ at 3-6 months of age, and deranged by cryptorchidism to cause seminoma and infertility
- Undescended testis and inguinal hernia result from defects in the same mechanism