Therapeutic Innovations in Affective Disorders

  • Healthscope Chair of Psychiatry

    Professor Chee Ng
    T: +61 3 9420 9350
    E: cng@unimelb.edu.au
    Location: The Melbourne Clinic, 130 Church Street Richmond Victoria
    W: Personal web page

Research Overview

Staff

Healthscope Professor of Psychiatry Professor Chee Ng

Collaborators

National

  • Deakin University and Barwon Health
  • RMIT
  • Swinburne University
  • UNSW
  • Black Dog Institute
  • University of Queensland

International

  • Peking University Institute of Mental Health
  • National University Singapore
  • National Center for Neurology and Psychiatry, Japan
  • College of Medicine, Korea University
  • Harvard Medical School
  • University of Macau, Macao SAR, China

Funding

  • N-acetyl cysteine for the treatment of OCD: 24 double-blind RCT 2016-2020 NHMRC project grant
  • SAFER Screening Project for ALKEMES adjunctive antidepressant study 2015. Harvard Medical School, MGH
  • CR Roper Medicine Faculty Fellowship 2014-2017. Melbourne University
  • Kava Research Grant: Integria Healthcare. Unrestricted grant (2015)
  • Kava in the Treatment of Generalized Anxiety Disorder: A 16 week RCT. NHMRC Project Grant APP1063383 (CIA) 2014
    Taki Mai Ausaid Development Grant. Fiji
  • Research Support Grant. The Blackmores Institute 2013
    The Efficacy of S-Adenosyl Methionine (SAMe) and a Combination Nutraceutical as Adjunctive Treatments in Depression NHMRC Project Grant 2012
  • Nutraceutical combination for chronic insomnia Sanofi-Aventis (Co-Investigator) 2012
  • A standardized Bacopa extract for treating ADHD. Soho-Flordis (Co-Investigator) 2012
  • A Mitochondrial Nutraceutical Combination in Treating Bipolar Disorder CRC ( Co-Investigator) 2011
  • Swisse Multivitamin Cognition and Stress Study. Swisse  (Co-Investigator) 2010
  • The Kava and Anxiety Lowering Medication Study: A Phase IV multi-centre RCT. Integria Health (Chief Investigator) 2010
  • Green-Lipped Mussel Extract to Treat ADHD: A pilot RCT. Pharmalink  (Co-Chief Investigator) 2010
  • The International Network of Integrative Mental Health (INIMH) development funding. Mann Foundation  (Co-Founder) 2010
  • Kava Anxiety Depression Spectrum Study (KADSS): A double-blind, placebo-controlled, cross-over clinical trial. MediHerb  (Chief Investigator) 2009
  • NHMRC Postdoctoral Clinical Research Fellowship: Research in the area of Complementary Medicine and Mental Health (Salary Funding) 2010
  • ASOMA (herbal medicine formula) in the treatment of chronic insomnia. Herbal Research Institute (Co-investigator) 2009
  • St John’s wort and Kava in the Treatment of Major Depressive Disorder and Comorbid Anxiety: A Randomised Double-Blind Placebo Controlled Study.  MediHerb (Chief Investigator) 2008

Research Publications

Bousman CA, Sarris J, Won ES, Chang HS, Singh AB, Ng CH. Escitalopram efficacy: A cross-ethnic examination of the serotonin transporter promoter polymorphism. Journal of Clinical Psychopharmacology 2014; 34(5): 645-8.

Bousman, CA., Katalinic, N., Martin, DM., Smith, DJ., Ingram, A., Dowling, N., Ng CH, Loo, C (2015). Effects of COMT, DRD2, BDNF, and APOE genotypic variation on cognitive side-effects and response to electroconvulsive therapy. Journal of ECT; 31(2):129-35.

Ng CH, Bousman C, Smith DJ, Dowling N, Byron K, King J, Sarris J (2016). Prospective Study of serotonin and norepinephrine transporter genes and the Response to Desvenlafaxine over 8 Weeks in Major Depressive Disorder. Pharmacopsychiatry (Accepted).

Ng CH, Sarris J, Singh A, Bousman CA, Byron K, Peh LH, Smith DJ, Tan CH, Schweitzer I (2013). Pharmacogenetic Polymorphisms and Response to Escitalopram and Venlafaxine over 8 Weeks in Major Depression. Human Psychopharmacology: Clinical and Experimental. 28: 516–522. doi: 10.1002/hup.2340.

Bousman CA, Sarris J, Won ES, Chang HS, Singh AB, Ng CH. Escitalopram efficacy: A cross-ethnic examination of the serotonin transporter promoter polymorphism. Journal of Clinical Psychopharmacology 2014; 34(5): 645-8.

Bousman, CA., Katalinic, N., Martin, DM., Smith, DJ., Ingram, A., Dowling, N., Ng CH, Loo, C (2015). Effects of COMT, DRD2, BDNF, and APOE genotypic variation on cognitive side-effects and response to electroconvulsive therapy. Journal of ECT; 31(2):129-35.

Ng CH, Bousman C, Smith DJ, Dowling N, Byron K, King J, Sarris J (2016). Prospective Study of serotonin and norepinephrine transporter genes and the Response to Desvenlafaxine over 8 Weeks in Major Depressive Disorder. Pharmacopsychiatry (Accepted).

Ng CH, Sarris J, Singh A, Bousman CA, Byron K, Peh LH, Smith DJ, Tan CH, Schweitzer I (2013). Pharmacogenetic Polymorphisms and Response to Escitalopram and Venlafaxine over 8 Weeks in Major Depression. Human Psychopharmacology: Clinical and Experimental. 28: 516–522. doi: 10.1002/hup.2340.

Ng C. Mental Health: Towards Economic and Social Inclusion: A report to the Commonwealth Secretariat to support the development of a focused theme on Mental Health for the Commonwealth Health Ministers Meeting (2013).  Commonwealth Secretariat, London.

Ng CH, Herrman H, Chiu E, Singh B (2009) Community mental health care in the Asia-Pacific region: using current best-practice models to inform future policy. World Psychiatry; 8 :49-55.

Sarris J, Murphy J, Mischoulon D, Papakostas GI, Fava M, Berk M, Ng C (2016). Adjunctive Nutraceuticals in the Treatment of Depression: A Systematic Review and Meta-analyses. American Journal of Psychiatry (in press).

Sarris J, Nishi D, Xiang YT, Su KP,  Bannatyne A, Oliver G, Kua EK, Ng CH (2015). Implementation of Psychiatric-Focused Lifestyle Medicine Programs in Asia. Asia Pacific Psychiatry; 7(4):345-54.

Schweitzer I, Sarris J, Tuckwell V, Maguire K, Smith, DJ., Ng C. (2013). Aripiprazole as Augmentation Therapy in Bipolar Patients with Current Minor or Subsyndromal Mood Symptoms. International Journal of Bipolar Disorders. 1:1-5.

Singh AB, Bousman CA, Ng CH, Byron K, Dean B, Berk M. ABCB1 Polymorphism Predicts Escitalopram Dose Needed for Remission in Major Depression. Translational Psychiatry (2012) 2, e198; doi:10.1038/tp.2012.115

Research Projects

Currently no project details available


Research Themes

Neuroscience

Areas of Excellence

Neuroscience and Psychiatry


Key Contact

For further information about this research, please contact
Professor Chee Ng.

Department / Centre

Psychiatry