Regulation of invadopodium function and involvement in cancer cell invasion

Project Details

A property shared by several types of tumour cells is an ability to form structures known as invadopodia. These are dynamic actin-dependent, membrane protrusions which proteolytically degrade extracellular matrix (ECM) substrates via the activities of numerous proteases. Invadopodia have been observed in tumour cell lines derived from various cancers including breast cancer, melanoma, prostate cancer, colon cancer, glioma and head and neck cancers, just to name a few. It is a continually evolving field and our aim is to undertsand how invadopodia are formed and regulated.

Researchers

Dr Stanley Stylli, Project Leader,

Justin Gourlay, PhD student

Clarissa Whitehead, Honours student

Collaborators

Dr Andrew Morokoff (University of Melbourne, Australia)
Dr Rodney Luwor (University of Melbourne, Australia)
Dr Hong-Jian Zhu (University of Melbourne, Australia)
Mr Cameron Nowell (Monash University, Australia)

Funding

Friends of The Royal Melbourne Hospital Neuroscience Foundation

Research Outcomes

1: Expression of the adaptor protein Tks5 in human cancer: prognostic potential.
Stylli SS, Luwor RB, Kaye AH, I ST, Hovens CM, Lock P.  Oncol Rep. 2014
Sep;32(3):989-1002. doi: 10.3892/or.2014.3310. Epub 2014 Jul 4. PubMed PMID:
24993883.

2: Prognostic significance of Tks5 expression in gliomas. Stylli SS, I ST, Kaye AH, Lock P. J Clin Neurosci. 2012 Mar;19(3):436-42. doi: 10.1016/j.jocn.2011.11.013. Epub 2012 Jan 16. PubMed PMID: 22249020.

3: Nck adaptor proteins link Tks5 to invadopodia actin regulation and ECM degradation. Stylli SS, Stacey TT, Verhagen AM, Xu SS, Pass I, Courtneidge SA, Lock P.  J Cell Sci. 2009 Aug 1;122(Pt 15):2727-40. doi: 10.1242/jcs.046680. Epub 2009 Jul 13. PubMed PMID: 19596797; PubMed Central PMCID: PMC2909319.

4: Invadopodia: at the cutting edge of tumour invasion. Stylli SS, Kaye AH, Lock P.  J Clin Neurosci. 2008 Jul;15(7):725-37. doi: 10.1016/j.jocn.2008.03.003. Epub 2008 May 12. Review. PubMed PMID: 18468901.

Research Publications

For a complete listing of Dr Stanley Stylli's publications on Research Gate
https://www.researchgate.net/profile/Stanley_Stylli/publications

Research Group

Brain Tumour Biology and Therapies



Faculty Research Themes

Neuroscience, Cancer

School Research Themes

Neuroscience & Psychiatry, Cancer



Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Surgery