Neurotrophins - how do they influence neural firing and ion channels?
Neurotrophins such as brain derived neurotrophic factor (BDNF) and neurotrophins 3 (NT3) are nerve growth factors that have been shown to successfully promote the survival of auditory neurons in deafness. This study examines the functional consequences of neurotrophins as a adjunct treatment for cochlear implants by determining how BDNF and NT3 control the electrical output of primary auditory neurons. In this project we employ cochlea microdissection, cell culture and patch-clamp recording techniques.
Professor Stephen O'Leary, Chair of Otolaryngology
Ms Kate Brody, Research Assistant
Senior Wagstaff Fellowship, Royal Victorian Eye & Ear Hospital
Cai HQ, Gillespie LN, Wright T, Brown WGA, Minter R, Nayagam B, O’Leary SJ, and Needham K. (2017) Time-dependent activity of primary auditory neurons in the presence of neurotrophins and antibiotics. Hearing Research 350: 122-132
Wright T, Gillespie LN, O’Leary SJ, and Needham K. (2016) Firing frequency and entrainment maintained in primary auditory neurons in the presence of combined BDNF and NT3. Scientific Reports 6, 28584
Needham K, Nayagam BA, Minter RL and O’Leary SJ. (2012) Combined application of brain-derived neurotrophic factor and neurotrophin-3 and its impact on spiral ganglion neuron firing properties and hyperpolarization-activated currents. Hearing Research 291: 1-14