SITA (Should I Take Aspirin?) Trial: A Randomised Control Trial of a decision aid to support informed choices about taking aspirin to prevent cancer and other chronic disease.

Project Details

Australian aspirin guidelines recommend that all people aged 50-70 years old actively consider taking daily low-dose aspirin for 2.5 to 5 years to reduce their risk of colorectal cancer (CRC).(1) This trial, SITA, is a randomised controlled trial (RCT) with general practice patients that aims to test the efficacy of a health consultation and use of a sex-specific decision aid, using an expected frequency tree (EFT) to present the benefits and harms of taking low dose aspirin, on two co-primary outcomes including informed decision-making at one month and uptake of aspirin at six-months. Control participants receive general information about modifiable risk factors for CRC prevention.


    Research Team

    Ms. Shakira R Milton, Trial Coordinator

    A/Prof Jennifer McIntosh

    Dr. Sibel Saya

    Prof Finlay Macrae

    Dr. Patty Chondros

    Ms. Lucy Boyd

    Ms. Rushani Wijesuriya

    Ms. Napin Karnchanachari

    Ms. Kitty Novy

    A/Prof Natalie Taylor

    Prof Mark Jenkins

    Dr. Fiona Walter

    Prof Lyndal Trevena

    Herman Prof Jon Emery

    Dr. Javiera Martinez Gutierrez

    Ms. Kate Broun

    Ms. Sarah McGill

    Dr. Sara Whitburn


    George Fishman

    Julie Marker

    Max Shub


The Primary Care Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK


The Victorian Comprehensive Cancer Centre’s (VCCC) Precision Prevention Program and the Victorian Cancer Agency.

Research Outcomes

This trial will provide evidence about the use of a decision aid to support informed choices about using low dose aspirin to reduce risk of cancer.

Research Group

Cancer in Primary Care

Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

General Practice and Primary Care

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