Cancer in Primary Care

Research Overview

The Primary Cancer Research Group was established at the University of Melbourne in 2013 and has become the biggest primary care cancer research team in the world. The team has accrued over $30,000,000 of funding and published over 160 publications since 2018. The research group has steadily grown and currently includes over 30 core team members working in three distinct areas:

*Data linkage – linking primary care data to hospital and clinical cancer registries to study the  patterns of care and impacts on patient outcomes, as part of a Victorian Comprehensive Cancer Centre (VCCC) Alliance research program.

*Clinical trials – we are currently running nine randomized controlled trials (RCTs) in general practice testing novel interventions covering cancer prevention, risk-based screening, pharmacogenomics, and early cancer diagnosis in primary care.

*Primary care trial infrastructure and capacity building – the Primary Care Collaborative Cancer Clinical Trials Group (PC4) and PARTNER national trial networks.

The evolution and growth of the team reflects the success in obtaining competitive research funding through effective national and international collaboration, and development of effective teams to execute research.

At a local level, the Primary Care Cancer Research Group has built strong collaborations with researchers from the School of Population and Global Health (Mark Jenkins, John Hopper), the School of Medicine (Finlay Macrae, Ingrid Winship), and the Department of General Practice (Jo-Anne Manski-Nankervis, Dougie Boyle, Lena Sanci, Patty Chondros). These collaborations have been critical to build programs on cancer genomics and risk-based prevention, creation of critical data infrastructure for data linkage and trials, and development of decision support tools.

Nationally, we work closely with research teams at the University of Western Australia, University Technology Sydney, University of Queensland, University of Sydney, Flinders University, and others. Many of these collaborations have been built through the successful engagement and processes established by PC4 (see below).

Internationally, we have a long-standing collaboration with researchers at the University of Cambridge as part of our program on cancer risk assessment and early detection. This led to our group being the Australian lead on the £5 million Cancer Research UK Cantest program, creating opportunities for our team to attend international research schools on early cancer diagnosis and develop collaborations with groups in the UK (Cambridge, UCL, Exeter, Oxford), the US and Denmark. Jon Emery and PC4 were approached to help establish primary care cancer networks in SE Asia, led through a collaboration at NUS in Singapore. The SPRINT (Singapore) and Asia Pacific Primary Care Cancer Research Group have been established and have led to collaborations on several Australian and Asian grants involving early and mid-career researchers. This is supported through the Primary Care Collaborative Cancer Clinical Trials Group (PC4) of which Prof Jon Emery is Director.

PC4- The Primary Care Collaborative Cancer Clinical Trials Group

PC4 is funded by Cancer Australia to support the development of high-quality cancer research in primary care. Our Group provides an infrastructure to foster collaboration between researchers, health care practitioners, policy makers and consumers. We provide access to expert advice and resources through our Support Services, and build research capacity with our Training Awards, Workshops and Mentoring Programs.  Further information about becoming a member of PC4 and learning more about ways to support your research is provided on the trial group’s website.

PARTNER

The PARTNER network is a national rural practice-based research network (PBRN) that connects rural Australians to potential clinical trials through their local GP. PARTNER creates an environment of research-ready GP practices that improves the efficiency and quality of trials conducted in primary care. PARTNER uses technology solutions to support identification of eligible patients for trials, for disease surveillance and trial follow-up.

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Staff

Dr. Rebecca Bergin – Honorary Fellow

Ms. Rachel Brooks – Research Support Nurse

Ms. Aradhana Chandra – Administration Officer

Ms. Sophie Chima – PhD Candidate/ Research Assistant

Dr. Deborah De Guingand – National Manager, IC3

Ms. Allison Drosdowsky – PhD Candidate/ Statistician

Dr. Jon Emery – Herman Chair of Primary Care Cancer Research, Director, PC4

Ms. Floriana La Rocca - Program Manager, Primary Care Trials Unit

Dr. Alex Lee - Research Fellow in Cancer Services and Data Science

Dr. Shaoke Lei – Research Fellow

Ms. Jamie Liew – Research Support Officer

Mr. Philip Ly – Research Assistant

Dr. Javiera Martinez-Gutierrez – Research Fellow

Dr. Jennifer McIntosh - Academic Specialist

Ms. Tarryn Miles - Research Assistant

Dr. Kristi Milley – National Manager, PC4

Mrs. Shakira Milton – Phd Candidate/Research Assistant

Ms. Sarah Nagorcka – Communications Coordinator

Ms. Sally Philip – Program Manager, VCCC Data-Driven Research Hub

Ms. Katerina Piakis - Research Assistant

Mr. Greg Poynter - Program Manager, PARTNER

Dr. Meena Rafiq - Research Fellow

Ms. Georgia Ramsay – Research Assistant

Dr. Sibel Saya – Research Fellow / Trials Coordinator

Ms. Silja Schrader – Health Data Analyst

Mr. Raushaan Seychell – ResearchAssistant

Ms. Zoe Siviour – Research Assistant

Mr. Matthew Thoenig - Research Officer

Dr. Brent Venning – Academic Registrar

Ms. Olivia Wawryk – Data Analyst, VCCC Data-Driven Research Hub

Ms. Anna Wood – Project Manager, SMARTscreen

Dr. Jianrong Zhang – PhD Candidate

Collaborators

Prof Jon Emery and his team have long-standing collaborations with researchers around the world in primary care, cancer, psychiatry, genomics, and linked data. These include a program of work with Prof Fiona Walter now at Queen Mary University of London (Wolfson Institute of Population Health) and formerly at the Department of Public Health and Primary Care, University of Cambridge, Dr Chad Bousman at the University of Calgary on the PRESIDE trial, and Dr Juliet Usher-Smith at Cambridge on the CanRisk program. Additionally, The  CanTest program, co-led by Prof Fiona Walter and Prof Willie Hamilton encompassed 42 collaborators from 11 institutions around the world with a focus on early cancer detection in primary care.  Current studies within this collaboration include SCRIPT, CRISP, IC3, CanRisk and the Melatools programme.

Other collaborators include:

  • Department of Health Victoria
  • Cancer Council of Australia
  • Cancer Council of Victoria
  • Victorian Comprehensive Cancer Centre
  • Health and Biomedical Informatics Centre, University of Melbourne
  • Centre for Epidemiology and Biostatistics, University of Melbourne
  • Royal Melbourne Hospital
  • Western Health
  • Peter MacCallum Cancer Centre
  • Department of Public Health and Primary Care, University of Cambridge
  • Department of General Practice, University of Sydney
  • Department of General Practice, Monash University
  • Department of Medicine, University of Western Australia

Funding

Our research is funded by the National Health and Medical Research Council (NHMRC), Cancer Australia, Cancer Council Victoria, Department of Health Victoria, Medical Research Future Fund (MRFF), Victorian Cancer Agency, the VCCC Alliance, Cancer Research UK, Paul Ramsay Foundation and the BUPA Foundation.

Research Publications

Research Publication Highlights from the Cancer Research Group:

Drosdowsky, A., Lamb, K. E., Bergin, R. J., Boyd, L., Milley, K., IJzerman, M. J., & Emery, J. D. (2023). A systematic review of methodological considerations in time to diagnosis and treatment in colorectal cancer research. Cancer Epidemiology83, 102323.

Emery, J., Jenkins, M. A., Saya, S., Chondros, P., Oberoi, J., Milton, S., ... & McIntosh, J. G. (2023). The CRISP Trial: RCT of a decision support tool for risk-stratified colorectal cancer screening. British Journal of General Practice.

Milley, K., Chima, S., Karnchanachari, N., McNamara, M., Druce, P., & Emery, J. (2023). General practice-based cancer research publications: a bibliometric analysis 2013–2019. British Journal of General Practice73(727), e133-e140.

Milley, K., Chima, S., McIntosh, J. G., Ackland, E., & Emery, J. D. (2021). Long‐term consumer involvement in cancer research: Working towards partnership. Health Expectations24(4), 1263-1269.

Milley, K., Chima, S., Thornton-Benko, E., & Emery, J. (2022). Embedding primary healthcare professionals as consumers in cancer research development. Australian Journal of General Practice51(8), 565-566.

Milton, S., McIntosh, J., Macrae, F., Chondros, P., Trevena, L., Jenkins, M., ... & Emery, J. (2021). An RCT of a decision aid to support informed choices about taking aspirin to prevent colorectal cancer and other chronic diseases: a study protocol for the SITA (Should I Take Aspirin?) trial. Trials22(1), 1-17.

Ristanoski, G., Emery, J., Martinez Gutierrez, J., McCarthy, D., & Aickelin, U. (2021, February). Handling uncertainty using features from pathology: opportunities in primary care data for developing high risk cancer survival methods. In 2021 Australasian Computer Science Week Multiconference (pp. 1-7).

Ristanoski, G., Emery, J., Gutierrez, J. M., McCarthy, D., & Aickelin, U. (2022). AI based cancer detection models using primary care datasets. Journal of Advances in Information Technology Vol13(2).

Saya, S., Boyd, L., Chondros, P., McNamara, M., King, M., Milton, S., ... & Emery, J. (2022). The SCRIPT trial: study protocol for a randomised controlled trial of a polygenic risk score to tailor colorectal cancer screening in primary care. Trials23(1), 810.

Wood, A., Emery, J. D., Jenkins, M., Chondros, P., Campbell, T., Wenkart, E., ... & McIntosh, J. G. (2022). The SMARTscreen Trial: a randomised controlled trial investigating the efficacy of a GP-endorsed narrative SMS to increase participation in the Australian National Bowel Cancer Screening Program. Trials23(1), 1-14.

Zhang, J., IJzerman, M. J., Oberoi, J., Karnchanachari, N., Bergin, R. J., Franchini, F., ... & Emery, J. D. (2022). Time to diagnosis and treatment of lung cancer: A systematic overview of risk factors, interventions and impact on patient outcomes. Lung Cancer166, 27-39.

Zhang, J., Oberoi, J., Karnchanachari, N., Druce, P., IJzerman, M. J., & Emery, J. D. (2021). The timeliness of lung cancer care: A systematic review of systematic/scoping reviews on time intervals and their impacts on cancer outcomes.

Please click here to view a complete citations list from the Cancer Research Group spanning over 220 publications since 2018.

Research Projects



Faculty Research Themes

Cancer

School Research Themes

Cancer in Medicine, Critical Care

Department / Centre

General Practice

Unit / Centre

Cancer in Primary Care

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