NHMRC Centre for Research Excellence for Reducing the Burden of Colorectal Cancer by Optimising Screening

Researcher

Project Details

For every one million Australians 50 years and older, an estimated 80,000 people have been over-screened with colonoscopies and 29,000 people have been under-screened with colonoscopies. The NHMRC has funded a Centre for Research Excellence: Optimising Colorectal Cancer Screening in Primary Care (CRE) to increase risk-stratified screening for colorectal cancer, to reduce the population’s disease burden from colorectal cancer and improve health services delivery.

The CRE is currently bringing together experts in clinical and non-clinical sciences:

  1. to develop the first personalised Colorectal cancer RISk Prediction tool ('CRISP') that incorporates all known genetic, pathology, family history, lifestyle factors and personal characteristics, and
  2. to develop proven methods for implementing CRISP in general practice.

The CRE program of research is following the Medical Research Council's Developing and Evaluating Complex Interventions (UK) to develop and validate complex interventions. The CRE will develop an accurate individual risk prediction model relevant to the Australian population, and the Primary Cancer Care team in the Department of General Practice are designing and trialling the risk prediction tool - CRISP – for use in general practice. The tool and model will be validated using data from the Colon Cancer Family Registry, a fully characterised study of both population-based and clinic-based participants measured for known and suspected risk factors including personal characteristics, environmental risk factors, complex family history and measured genetic variants.

Researchers

Professor Jon Emery, Herman Professor of Primary Care Cancer Research
Associate Professor Marie Pirotta, NHMRC Career Development Fellow
Dr Jennifer Walker, Senior Research Fellow
Dr Patty Chondros, Senior Research Fellow
Jasmeen Oberoi, Research Support Officer 
Shakira Milton, Research Support Officer
Emily Habgood, Research Assistant/PhD Candidate 
Sibel Saya, Research Assistant/PhD Candidate
Kitty Novy, Administrative support

Collaborators

Centre for Epidemiology & Biostatistics, University of Melbourne
Royal Melbourne Hospital
Western Health
Peter McCallum Cancer Centre
Cancer Council of Victoria
Department of Health Victoria
Victorian Comprehensive Cancer Centre
University of Technology, Sydney

Funding

NHMRC Centre for Research Excellence [APP1042021]
Victorian Cancer Agency Health Services Research [HSR15019]

Research Outcomes

  1. J Walker, F Macrae, I Winship, J Oberoi, S Saya, A Bickerstaffe, J Dowty, R De Abreu Lourenço, M Clark, L Galloway, G Fishman, FM Walter, L Flander, P Chondros, D Ait Ouakrim, M Pirotta, L Trevena, MA Jenkins, JD Emery. The use of a risk assessment and decision support tool (CRISP) compared with usual care in general practice to increase risk-stratified colorectal cancer screening: study protocol for a randomized controlled trial. Trials (2018 19:397).
  2. J Emery, M Pirotta, F Macrae, J Walker, A Qama, A Boussioutas, A Ko Win, M Jenkins. ''Why don't I need a colonoscopy?':  a novel approach to communicating risks and benefits of colorectal cancer screening.' AJGP, 2018 47:6.
  3. GY Kim, J Walker, A Bickerstaffe, N Hewabandu, M Pirotta, L Flander, M Jenkins, J Emery. The CRISP-Q study: Communicating the risks and benefits of colorectal cancer screening. AJGP, (2018 47:3).
  4. J Walker, A Bickerstaffe, N Hewabandu, et al. The CRISP colorectal cancer risk prediction tool: an exploratory study using simulated consultations in Australian primary care. BMC Med Inf Dec Mak (2017 17:13).
  5. JA Usher-Smith, FM Walter, JD Emery, AK Win, SJ Griffin. Risk prediction models for colorectal cancer: a systematic review. Cancer Prevention Research (2016 9:1).
  6. J Walker, S Licqurish, PPC Chiang, et al. Cancer risk assessment tools in primary care: a systematic review of randomized controlled trials. Ann Fam Med, (2015 13:5).

Papers and posters presented

  1. J Walker, A Bickerstaffe, N Hewabandu, S Saya, J Oberoi, M Jenkins, J Emery. A novel colorectal cancer risk prediction tool (CRISP): from inception to implementation, tales from down under. North American Primary Care Research Group Annual Meeting, Montreal, Canada 2017
  2. J Walker, A Bickerstaffe, N Hewabandu, S Saya, J Oberoi, M Jenkins, J Emery. A novel colorectal cancer risk prediction tool (CRISP): from inception to implementation, tales from down under. Department of Public Health, Washington University St Louis, St Louis, USA October 2017.
  3. J Walker, A Bickerstaffe, N Hewabandu, S Saya, J Oberoi, M Jenkins, J Emery. What is the NHMRC Centre for Research Excellence Reducing the burden of colorectal cancer by optimising screening: evidence to clinical practice.? Kansas Patients and Providers Engaged in Prevention Research (KPPEPR), University of Kansas, Kansas City, USA 2017
  4. J Walker, S Saya, G Y Kim, J L Minshall, E Harty, S Licqurish, L Flander, A Bickerstaffe, N Hewabandu, M Jenkins, J Emery. Involving patients in the development of a colorectal cancer risk prediction tool. PC4 Scientific Symposium, Sydney, Australia, 2018
  5. J Walker, S Saya, G Y Kim, J L Minshall, E Harty, S Licqurish, L Flander, A Bickerstaffe, N Hewabandu, M Jenkins, J Emery. Involving patients in the development of a colorectal cancer risk prediction tool. Ca-PRI Conference, Groningen, The Netherlands, 2018
  6. J Walker, M Jenkins, M Pirotta, et al. CRISP: a novel colorectal cancer risk prediction tool. Is it acceptable and feasible in Australian primary care? Society for Academic Primary Care (SAPC) Conference, Dublin Ireland. July 2016
  7. J Walker, GY Kim, A Bickerstaffe, N Hewabandu, M Pirotta, M Jenkins, JD Emery. The ‘CRISP-Q’ study: which communication methods facilitate risk-appropriate colorectal cancer screening choices for patients in general practice? CCV Behavioural Conference 2016, Melbourne, Victoria
  8. M Jenkins, M Pirotta, JD Emery, J Walker, I Winship, F Macrae, JL Hopper, JP Young, A Boussioutas, GG Giles, J Bishop, S Parry, AK Win, C Rosty, M Southey, R MacInnis, L Keogh, C Gaff, L Galloway. What is the NHMRC Centre for Research Excellence Reducing the burden of colorectal cancer by optimising screening: evidence to clinical practice.? World Cancer Congress 2014, Melbourne, Australia

Data collection and analysis ongoing.

Research Group

Cancer in Primary Care



Faculty Research Themes

Cancer

School Research Themes

Cancer in Medicine



Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

General Practice

Unit / Centre

Cancer in Primary Care


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