Jason Kwong

Research Overview

Our research focuses on the epidemiology, prevention and control of healthcare-associated infections. In particular, we are involved and lead several studies to better prevent and control the spread of multidrug-resistant organisms ("superbugs") such as VRE (vancomycin-resistant enterococci) and CPE (carbapenemase-producing Enterobacterales) in hospitals through the use of genomic technologies. We collaborate extensively with the Microbiological Diagnostic Unit Public Health Laboratory, the Department of Microbiology & Immunology, University of Melbourne, and the Department of Health Victoria.

Broadly, our studies include:

  • Using genomics to understand the spread of multidrug-resistant organisms in hospitals
  • Clinical implementation of real-time genomics to enhance hospital infection prevention and control responses
  • Developing metagenomic and microbiome approaches to improve diagnosis, treatment and control of infectious diseases

Staff

  • Ms Fiona James (Research Manager)
  • Dr Dorothy Ling (Project Coordinator & Clinical Lead)
  • Ms Jordana Flude (Research Assistant)
  • Mr Jolian Poliss (Research Scientist)
  • Dr Liv Smibert (Clinician & PhD candidate)
  • Ms Nicole Isles (PhD candidate)
  • Ms Sara Zufan (PhD candidate)
  • Dr Janet Cao (Clinician & PhD candidate)

Collaborators

  • Prof Ben Howden - Microbiological Diagnostic Unit Public Health Laboratory
  • Dr Norelle Sherry - Microbiological Diagnostic Unit Public Health Laboratory
  • Prof Tim Stinear - Department of Microbiology & Immunology, University of Melbourne
  • Prof Deb Williamson - Victorian Infectious Diseases Reference Laboratory

Funding

  • NHMRC Early Career Fellowship
  • MRFF - Pathogen Genomics
  • Melbourne Genomics Health Alliance
  • MRFF - Keeping Australians out of Hospital
  • MRFF - Dementia, Ageing and Aged Care

Research Outcomes

Research Publications

  1. Sherry NL, et al. Multi-site implementation of whole genome sequencing for hospital infection control: a prospective genomic epidemiological analysis. Lancet Reg Health West Pac, 2022; 23: 100446; doi: 10.1016/j.lanwpc.2022.100446.
  2. Isles NS, et al. Gut microbiome signatures and host colonization with multidrug-resistant bacteria. Trends Microbiol, 2022; S0966-842X(22)00013-0; doi: 10.1016/j.tim.2022.01.013.
  3. Higgs C, et al. Optimising genomic approaches for identifying vancomycin-resistant Enterococcus faecium transmission in healthcare settings. Nat Commun, 2022; 13(1): 509; doi: 10.1038/s41467-022-28156-4.
  4. Gorrie CL, et al. Key parameters for genomics-based real-time detection and tracking of multidrug-resistant bacteria: a systematic analysis. Lancet Microbe, 2021; 2(11): e575-e583; doi: 10.1016/S2666-5247(21)00149-X.
  5. Smibert OC, et al. An infectious diseases perspective on the microbiome and allogeneic stem cell transplantation. Curr Opin Infect Dis, 2020; 33(6): 426-432. doi: 10.1097/QCO.0000000000000683.
  6. Lane CR, et al. Search and contain: impact of an integrated genomic and epidemiological surveillance and response program for control of carbapenemase-producing Enterobacterales. Clin Infect Dis, 2020. doi: 10.1093/cid/ciaa972.

Research Projects

This Research Group doesn't currently have any projects



Faculty Research Themes

Infection and Immunology



Key Contact

For further information about this research, please contact Associate Professor Jason Kwong

Department / Centre

Infectious Diseases

Unit / Centre

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