Our research focuses on the epidemiology, prevention and control of healthcare-associated infections. In particular, we are involved and lead several studies to better prevent and control the spread of multidrug-resistant organisms ("superbugs") such as VRE (vancomycin-resistant enterococci) and CPE (carbapenemase-producing Enterobacterales) in hospitals through the use of genomic technologies. We collaborate extensively with the Microbiological Diagnostic Unit Public Health Laboratory, the Department of Microbiology & Immunology, University of Melbourne, and the Department of Health Victoria.
Broadly, our studies include:
- Using genomics to understand the spread of multidrug-resistant organisms in hospitals
- Clinical implementation of real-time genomics to enhance hospital infection prevention and control responses
- Developing metagenomic and microbiome approaches to improve diagnosis, treatment and control of infectious diseases
- Ms Fiona James (Research Manager)
- Dr Dorothy Ling (Project Coordinator & Clinical Lead)
- Ms Jordana Flude (Research Assistant)
- Mr Jolian Poliss (Research Scientist)
- Dr Liv Smibert (Clinician & PhD candidate)
- Ms Nicole Isles (PhD candidate)
- Ms Sara Zufan (PhD candidate)
- Dr Janet Cao (Clinician & PhD candidate)
- Prof Ben Howden - Microbiological Diagnostic Unit Public Health Laboratory
- Dr Norelle Sherry - Microbiological Diagnostic Unit Public Health Laboratory
- Prof Tim Stinear - Department of Microbiology & Immunology, University of Melbourne
- Prof Deb Williamson - Victorian Infectious Diseases Reference Laboratory
- NHMRC Early Career Fellowship
- MRFF - Pathogen Genomics
- Melbourne Genomics Health Alliance
- MRFF - Keeping Australians out of Hospital
- MRFF - Dementia, Ageing and Aged Care
- Sherry NL, et al. Multi-site implementation of whole genome sequencing for hospital infection control: a prospective genomic epidemiological analysis. Lancet Reg Health West Pac, 2022; 23: 100446; doi: 10.1016/j.lanwpc.2022.100446.
- Isles NS, et al. Gut microbiome signatures and host colonization with multidrug-resistant bacteria. Trends Microbiol, 2022; S0966-842X(22)00013-0; doi: 10.1016/j.tim.2022.01.013.
- Higgs C, et al. Optimising genomic approaches for identifying vancomycin-resistant Enterococcus faecium transmission in healthcare settings. Nat Commun, 2022; 13(1): 509; doi: 10.1038/s41467-022-28156-4.
- Gorrie CL, et al. Key parameters for genomics-based real-time detection and tracking of multidrug-resistant bacteria: a systematic analysis. Lancet Microbe, 2021; 2(11): e575-e583; doi: 10.1016/S2666-5247(21)00149-X.
- Smibert OC, et al. An infectious diseases perspective on the microbiome and allogeneic stem cell transplantation. Curr Opin Infect Dis, 2020; 33(6): 426-432. doi: 10.1097/QCO.0000000000000683.
- Lane CR, et al. Search and contain: impact of an integrated genomic and epidemiological surveillance and response program for control of carbapenemase-producing Enterobacterales. Clin Infect Dis, 2020. doi: 10.1093/cid/ciaa972.
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For further information about this research, please contact Associate Professor Jason Kwong
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