Anaesthesia, Perioperative and Pain Medicine Unit (APPMU)


Research Overview

Located within the Melbourne Medical School, the Anaesthesia, Perioperative and Pain Medicine Unit (APPMU) promotes multi-centre research with the Departments of Anaesthesia at the 14 hospitals affiliated with the University. APPMU also engages in collaborative and translational research with other clinical and biomedicine departments, and with the Clinical Trials Network of the Australian and New Zealand College of Anaesthetists (ANZCA). Areas of particular interest include measures to improve long term patient recovery after surgery through evidence-based perioperative care and pain medicine.


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Anna Parker, APPMU Manager, MBioeth, MA, BA(Hons)
Sofia Sidiropoulos, ROCKet Trial Manager
Gayle Claxton, ROCKet Trial Coordinator

Simon Chong, DMedSc student
Jai Darvall, PhD student
Marissa Fergusson, MMed student
Scott McAlister, PhD student
Lachlan Miles, PhD student
Neda Taghizadeh, PhD student
Phung To, PhD student
Laurence Weinberg, PhD student

Honorary appointments

Prof Kate Leslie
Prof Philip Peyton
Prof Bernhard Reidel
Prof David Scott
Prof Daryl Williams

A/Prof David Andrews
A/Prof Michael Barrington
A/Prof Andrew Bjorksten
A/Prof Alicia Dennis 
A/Prof Lisbeth Evered
A/Prof Malcolm Hogg
A/Prof David Pescod
A/Prof Reny Segal
A/Prof Laurence Weinberg

Dr Kara Allen
Dr Megan Allen
Dr Lahiru Amaratunge
Dr Anjalee Brahmbhatt
Dr Simon Chong
Dr Jason Chou
Dr John Cormack
Dr Tim Coulson 
Dr Dean Cowie
Dr Anthony Cross
Dr Oliver Daly
Dr Louise Ellard
Dr Robyn Gillies
Dr Alison Graham
Dr Jonathan Graham
Dr Gaylene Heard
Dr Elizabeth Hessian
Dr Jonathon Hiller
Dr Brad Hockey
Dr Phillipa Hore
Dr Raymond Hu
Dr Andrew Huang
Dr Georgina Imberger
Dr Craig Ironfield
Dr Hilmy Ismail
Dr Andrew Jeffreys
Dr Charles Kim
Dr Roman Kluger 
Dr Juliana Kok
Dr Anthony Leaver
Dr Keat Lee
Dr Jamahal Luxford
Dr Lachlan Miles
Dr James Mitchell
Dr Irene Ng
Dr Martin Nguyen
Dr Brett Pearce
Dr Elizabeth Pemberton
Dr Tuong Phan
Dr Ben Slater
Dr Gabriel Snyder
Dr Chong Tan
Dr Niki Tan
Dr Rowan Thomas
Dr David Tremewan
Dr Alistair Walpole
Dr Crispin Wan
Dr Daniel Wong


Prof Michael Bailey, Clinical Trials Biostatistician
Prof Rinaldo Bellomo
Prof George Braitberg
Prof Matthew Chan
Prof Philip Clarke
Prof Christopher Cristophi
Prof Andrew Davidson
Prof Linda Denehy 
Prof Shaun Ewen
Prof Michael Fischer
Prof John Hajek
Prof David Howells
Prof Stephan Schug
Prof Julie Simpson

A/Prof Clare Delany
A/Prof Briony Dow
A/Prof Robyn Woodward Kron

Dr Douglas Boyle
Ms Sabine Braat
Dr Kim Dalziel
Dr Elif Ekinci
Dr Jo-anne Hughson
Dr Emily Karahalios
Dr Terry Judd
Dr Karen Lamb
Dr Wally Smith
Ms Michelle Tew
Dr Greg Wadley


Australian and New Zealand College of Anaesthetists Academic Enhancement Grant, 2018. A/Prof Alicia Dennis, Royal Women's Hospital. A haemodynamic and cardiovascular research program in obstetric anaesthesia and obstetric critical care at The Royal Women’s Hospital.

Australian and New Zealand College of Anaesthetists Novice Grant 2018. Dr Ned Douglas, Royal Melbourne Hospital. High flow humidified nasal oxygen to prevent desaturation during EBUS - a randomised controlled trial.

Australian and New Zealand College of Anaesthetists Project Grant, 2018. Prof Guy Ludbrook, Prof David Story. Extended Post-Anaesthesia Care – a feasibility study.

Australian and New Zealand College of Anaesthetists Project Grant, 2018. Prof Bernhard Riedel, Peter MacCallum Cancer Centre. Volatile Anaesthesia and Perioperative Outcomes Related to Cancer: The VAPOR-C Trial (Feasibility Study).

Australian and New Zealand College of Anaesthetists Project Grant, 2018. Dr Forbes McGain, Western Health. Capturing anaesthetic gases; an exploration of the chemistry and chemical engineering required to capture and potentially reuse sevoflurane.

Australian and New Zealand College of Anaesthetists Project Grant, 2018. Dr Jai Darvall, Prof Kate Leslie, Royal Melbourne Hospital. A randomized non-inferiority trial of chewing gum versus ondansetron to treat postoperative nausea and vomiting in female patients after breast and laparoscopic surgery (The Chewing Gum Study).

Australian and New Zealand College of Anaesthetists Project Grant, 2018. Dr Tuong Phan, St Vincent's Hospital. Optimisation of Perioperative Cardiovascular Management to Improve Surgical Outcomes II “OPTIMISE II” - AUSTRALIA.

Australian and New Zealand College of Anaesthetists Project Grant, 2018. Dr Lachlan Miles, Austin Health. A prospective observational study examining the impact of iron deficiency on patient outcomes after cardiac surgery.

Australian and New Zealand College of Anaesthetists Project Grant, 2018. Dr Lachlan Miles, Austin Health. Impact of non-anaemic iron deficiency correction on exercise capacity and perioperative outcomes in colorectal cancer surgery (ADEPT).

NHMRC Project Grant (APP1120848) 2017. Peyton P, Leslie K, Story D, Myles P, Chan M, Schug S, Evered L, Braat S. Reduction Of Chronic Post-surgical Pain with Ketamine – ROCKet Trial. $4,800,000 over 5 years.

ANZCA Melbourne Emerging Anaesthesia Researcher Award 2016. Dr Lachlan Miles, Austin Health. Iron Therapy for Non-Anaemic Iron Deficiency in Perioperative Colorectal Malignancy (FeRIC-II).

Australian and New Zealand College of Anaesthetists Novice Investigator Grant, 2016. Furyk C (Story D, supervisor). Prehabilitation of frail patients undergoing elective colorectal surgery - a feasibility pilot study.

Office of Research Ethics and Integrity, The University of Melbourne, Ethics and Integrity Development Grant, 2016. Woodward-Kron R, Hughson J, Parker A, Bresin A, Hajek J, Knoch U, Phan T, Story D. Let’s talk about medical research: Research equity for Culturally and Linguistically Diverse (CALD) older patients.

Western Health Research Grant 2016. Daly JO, Bennett J , Ostaszkiewicz P, Story D, Joyce D. MINisling Insertion in Ambulatory settings under Local anaesthetic (MINImAL) feasibility study: A qualitative study comparing patient attitudes to three modes of anaesthesia for the insertion of mid-urethral slings to treat women with stress urinary incontinence.

Australian and New Zealand College of Anaesthetists, Academic Enhancement Grant, 2015. Story, D. Emerging Projects for the Anaesthesia, Perioperative and Pain Medicine Unit (APPMU)  at The University of Melbourne.

ANZCA Melbourne Emerging Anaesthesia Researcher Award 2015. Dr Hugh Taylor, Western Health. A pilot study to investigate post ­‚Äźoperative oxygen consumption (POpOC) after colorectal surgery requiring bowel resection.

Australian and New Zealand College of Anaesthetists Trials Network Pilot Grant 2015. Allen M, Parker A, Story D. C-CaFe pilot study.

Macedon Ranges North Western Melbourne Medicare Local Grant, 2015. Story D, Daly O, Liberatore R, Abbey C, Blake K, Hajek J, Smith W, Ploderer B, Parker A,  Kerr C. We HELP: Western e-HEaLth patient information portal for Pregnancy.

ANZCA Melbourne Emerging Anaesthesia Researcher Award 2014. A/Prof Laurence Weinberg, Austin. Comparison of the Effects of Bolus vs. Slow Infusion of Crystalloid in Healthy Volunteers with Compensated Shock – a Pilot Study.

NHMRC Project Grant (APP1079501) 2014. Corcoran T, Myles P, Bellomo R, Forbes A, The Perioperative ADministration of Dexamethasone and Infection: The PADDI trial (Story D, AI).

Melbourne Networked Society Institute (MNSI) seed funding, 2014. Story D, Hajek J, Knoch U,  Woodward-Kron R, Phan T. Culturally And Linguistically Diverse Ethics and Research resources (The CALDER Pilot Study).

Melbourne Medical School, The University of Melbourne, MMS Research Seed Funding Grant, 2013. Story D, Martin-Sanchez F, Wlodek M, Teale G, Gerace E, Hessian E.The effect of Health Informatics on maternal weight stabilization at an obesity and pregnancy clinic; a pilot study (The Hi MUM pilot).

Office of Research Ethics and Integrity, The University of Melbourne, Ethics and Integrity Development Grant, 2013. Story D.Survey of approval processes for HRECs at University of Melbourne affiliated hospitals.

Australian and New Zealand College of Anaesthetists Trials Group Pilot Grant, 2013. Story D.Pilot grant application: Association between maternal size and outcomes for caesarean section; a multicentre prospective observational study (The MUM SIZE Study) – A Pilot Study.

Austin Medical Research Foundation Grant, 2013. Weinberg, Irenio, Story Peyton, McNicol.Fluid intervention for cadaveric renal transplantation.

NHMRC Project Grant (APP1043755) 2013. Myles P, Bellomo R, Forbes A, Corcoran T, Christophi C, Peyton P, Story D.Restrictive versus Liberal Fluid Therapy in Major Abdominal Surgery: The RELIEF Trial.

Australian and New Zealand College of Anaesthetists Research Grant, 2013. McGain F, Story D.A life cycle assessment of reusable and single use laryngoscopes.

Research Publications

Myles PS, Bellomo R, Corcoran T, Forbes A, Peyton P, Story D et al. Restrictive versus Liberal Fluid Therapy for Major Abdominal Surgery. New England Journal of Medicine. doi:10.1056/NEJMoa1801601 10 May 2018.

Boden I, Skinner EH, Browning L, Reeve J, Anderson L, Hill C, Robertson IK, Story D, Denehy L. Preoperative physiotherapy for the prevention of respiratory complications after upper abdominal surgery: pragmatic, double blinded, multicentre randomised controlled trial. BMJ 360:j5916 24 Jan 2018.

Story DA, Leslie K, French C. Feasibility and pilot studies: small steps before giant leaps. Anaesth Intensive Care 46(1):11-12 Jan 2018.

Smith W, Wadley G, Daly JO, Webb M, Hughson J, Hajek J, Parker A, Woodward-Kron R, Story DA. Designing an App for Pregnancy Care for a Culturally and Linguistically Diverse Community. OzCHI 2017, Brisbane, Australia, 28 Nov 2017 - 01 Dec 2017. The Association for Computing Machinery. 337-346 (10 pages). 2017.

Hughson J-A, Marshall F, Daly JO, Woodward-Kron R, Hajek J, Story D. Health professionals' views on health literacy issues for culturally and linguistically diverse women in maternity care: barriers, enablers and the need for an integrated approach. Australian Health Review 2017.

Weinberg L, Chiam E, Hooper J, Liskaser F, Hawkins AK, Massie D, Ellis A, Tan CO, Story D, Bellomo R. Plasma-Lyte 148 vs. Hartmann's solution for cardiopulmonary bypass pump prime: a prospective double-blind randomized trial. Perfusion 267659117742479 01 Nov 2017.

Weinberg L, Harris L, Bellomo R, Ierino FL, Story D, Eastwood G, Collins M, Churilov L, Mount PF. Effects of intraoperative and early postoperative normal saline or Plasma-Lyte 148 (R) on hyperkalaemia in deceased donor renal transplantation: a double-blind randomized trial. British Journal of Anaesthesia 119(4):606-615 (10 pages) 01 Oct 2017.

Miles LF, Story DA, Litton E. Peri-operative correction of non-anaemic iron deficiency. Anaesthesia, 2017 Jul 1, 72(7): 910-911.

McGain F, Story D, Lim T, McAlister S. Financial and environmental costs of reusable and single-use anaesthetic equipment. British Journal of Anaesthesia. 2017 Jun 1, 118(6):862-869.

Lee M, Weinberg L, Pearce B, Scurrah N, Story DA, Pillai P, McCall PR, McNicol LP, Peyton PJ. Agreement in hemodynamic monitoring during orthotopic liver transplantation: a comparison of FloTrac/Vigileo at two monitoring sites with pulmonary artery catheter thermodilution
Journal of Clinical Monitoring and Computing. 2017 Apr 1, 31(2):343-351.

Leslie K, Hopf HW, Houston P, O'Sullivan E. Women, Minorities, and Leadership in Anesthesiology: Take the Pledge. Anesthesia and Analgesia. 2017 May;124(5):1394-1396.

Keon-Cohen Z, Myles P, Story D. A survey of Australian and New Zealand anaesthetists’ attitudes towards resuscitation orders in the perioperative setting. Anaesthesia and Intensive Care. 2017 May; 45(3):396-402.

Machan L, Churilov L, Hu R, Peyton P, Tan C, Pillai P, Ellard L, Harley I, Story D, Hayward P, Matalanis G, Roubos N, Seevanayagam S, Weinberg L. Apneic Oxygenation Versus Low-Tidal-Volume Ventilation in Anesthetized Cardiac Surgical  Patients: A Prospective, Single-Center, Randomized Controlled Trial. J Cardiothorac Vasc Anesth. 2016 Dec 30. doi:10.1053/j.jvca.2016.12.019. [Epub ahead of print].

Myles P, Bellomo R, Corcoran T, Forbes A, Wallace S, Peyton P, Christophi C, Story D, Leslie K, Serpell J, McGuinness S, Parke R; Australian and New Zealand College of Anaesthetists Clinical Trials Network, and the Australian and New Zealand Intensive Care Society Clinical Trials Group. Restrictive versus liberal fluid therapy in major abdominal surgery (RELIEF): rationale and design for a multicentre randomised trial. BMJ Open. 2017 Mar 3;7(3).

Weinberg L, Huang A, Alban D, Jones R, Story D, McNicol L, Pearce B. Prevention of hypothermia in patients undergoing orthotopic liver transplantation using the humigard® open surgery humidification system: a prospective randomized  pilot and feasibility clinical trial. BMC Surg. 2017 Jan 23;17(1):10.

McAlister S, Ou Y, Neff E, Hapgood K, Story D, Mealey P, McGain F. The Environmental footprint of morphine: a life cycle assessment from opium poppy farming to the packaged drug. BMJ Open. 2016 Oct 21;6(10).

Goulding K, Peyton P, Story D, Parker A, Leslie K.Survey of research capability at Australian and New Zealand College of Anaesthetists accredited training sites. Anaesth Intensive Care 2017 Mar;45(2):196-201.

Darvall J, Parker A, Story D. Feasibility and acceptability of remotely monitored pedometer-guided physical activity. Anaesth Intensive Care 2016. 44:4.

McGain F, Welton R, Solley GO, Winkel KD. First fatalities from tick bite anaphylaxis. J Allergy Clin Immunol Pract. 2016 Jul-Aug; 4(4):769-70.

Hughson J, Woodward-Kron R, Parker A, Bresin A, Hajek J, Knoch U, Phan T, Story D. A review of approaches to improve participation of culturally and linguistically diverse populations in clinical trials. Trials, 2016 May, 17: 263.

Woodward-Kron R, Hughson J, Parker A, Bresin A, Hajek J, Knoch U, Phan T, Story D. Culturally and linguistically diverse populations in medical research: perceptions and experiences of older Italians, their families, ethics administrators and researchers. Journal of Public Health Research, Special lssue, April 2016. 5: 667, 43-51.

Story D. (Open Mind) Stewart acid-base: a simple bedside approach. Anesthesia and Analgesia. 2016 Aug;123(2):511-5.

Story D, Botz G, Jones D. The Role of Rapid Response Teams in the Postoperative Care of the High-Risk Cancer Patient.  Current Anesthesiology Reports, Published online July 8, 2015.

Taghizadeh N, Davidson A, Williams K, Story D. Autism spectrum disorder (ASD) and its preoperative management. Paediatric Anaesthesia. 2015, 25(11):1076-84.

Research Projects

School Research Themes

Integrated Critical Medicine

Key Contact

For further information about this research, please contact David Story

Department / Centre

Medicine and Radiology

Unit / Centre

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