An antibody that detects a high molecular weight surrogate ligand of calcitonin receptor is detected in malignant glioma cells and cell lines.
An antibody was developed that binds high molecular weight targets (HMWT) with similar properties to the natural ligands of the calcitonin receptor (CTR). A similar HMWT has recently been described as a surrogate ligand of CTR that promotes quiescence of skeletal muscle satellite (stem) cells via activation of the NOTCH-COLLAGEN V-CTR axis. The detected HMWTs are found expressed by malignant cells of brain tumours and cell lines. The biochemical identification of this HMWT is a current objective. Understanding the role of this HMWT is likely to contribute to our understanding of endocrine-like tumours and foetal development.
- Dr Peter Wookey
- Pragya Gupta – PhD student
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