The development of anti-NPY1 receptor antibodies for research into and treatment of cardiovascular diseases and cancer.
NPY is an important hormone and via one of its targets, NPY1 receptor, induces vasoconstriction and thickening of the neo-intima in cardiovascular disease (CVD). This receptor is also expressed by cancer cells of the breast. An anti-human NPY1 receptor antibody has been developed against a unique target in the extracellular domain of the receptor. This antibody will be developed as an immunotoxin or imaging reagent for potential treatment or imaging of CVD and breast cancer respectively
- Dr Peter Wookey
- Pragya Gupta – PhD student
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