PROMPT BOLUS Study
Project Details
PROMPT BOLUS (PRagMatic Pediatric Trial of Balanced vs nOrmaL Saline FlUid in Sepsis)
PROMPT BOLUS (PRagMatic Pediatric Trial of Balanced vs nOrmaL Saline FlUid in Sepsis) is a clinical trial to compare two commonly used treatments for pediatric sepsis to see if one is more effective and safer than the other. The treatments in this study are two different intravenous (IV) fluids: normal saline (NS) and lactated Ringer's (LR).
Thousands of children die from septic shock each year worldwide. Most children admitted with sepsis receive initial resuscitation in an emergency department (ED), where septic shock remains one of the most critical illnesses. We know that all crystalloid fluids help to reverse shock, but we're not yet sure which type of crystalloid fluid resuscitation is the most effective and safest. This trial is designed to provide the answer.
To definitively test the comparative effectiveness of NS and LR, a large pragmatic randomised trial embedded within everyday clinical practice provides a cost-efficient and generalisable method of informing best practice.
Our group, based at the Royal Children's Hospital in Melbourne, will be recruiting participating sites in Australia.
Researchers
Principal Investigators (Australia)
Prof Franz Babl (Royal Children's Hospital; Murdoch Children's Research Institute, Department of Critical Care, Paediatrics, University of Melbourne)
Dr Elliot Long (Royal Children's Hospital; Murdoch Children's Research Institute, Department of Critical Care, Paediatrics, University of Melbourne)
Associate Professor Ed Oakley (Royal Children's Hospital; Murdoch Children's Research Institute, Department of Critical Care, Paediatrics, University of Melbourne)
Principal Investigators (US)
Professor Nate Kupperman (UC Davis Children's Hospital)
Professor Fran Belamuth (Children's Hospital of Philadelphia)
Professor Scott Weiss (Children's Hospital of Philadelphia)
Collaborators
PREDICT Network (Paediatric Research in Emergency Departments International Collaborative)
Royal Children's Hospital, Melbourne
Murdoch Children's Research Institute
Children's Hospital of Philadelphia
UC Davis Children's Hospital
Funding
Medical Research Future Fund ($3,000,000+)
Contact
For enquiries or to register your interest contact fbabl@unimelb.edu.au or Elliot.long@rch.org.au
Research Group
School Research Themes
Key Contact
For further information about this research, please contact the research group leader.
Department / Centre
MDHS Research library
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