PROMPT BOLUS Study

Project Details

PROMPT BOLUS logo

PROMPT BOLUS (PRagMatic Pediatric Trial of Balanced vs nOrmaL Saline FlUid in Sepsis)

PROMPT BOLUS (PRagMatic Pediatric Trial of Balanced vs nOrmaL Saline FlUid in Sepsis) is a clinical trial to compare two commonly used treatments for pediatric sepsis to see if one is more effective and safer than the other. The treatments in this study are two different intravenous (IV) fluids: normal saline (NS) and lactated Ringer's (LR).

Thousands of children die from septic shock each year worldwide. Most children admitted with sepsis receive initial resuscitation in an emergency department (ED), where septic shock remains one of the most critical illnesses. We know that all crystalloid fluids help to reverse shock, but we're not yet sure which type of crystalloid fluid resuscitation is the most effective and safest. This trial is designed to provide the answer.

To definitively test the comparative effectiveness of NS and LR, a large pragmatic randomised trial embedded within everyday clinical practice provides a cost-efficient and generalisable method of informing best practice.

Our group, based at the Royal Children's Hospital in Melbourne, will be recruiting participating sites in Australia.

Researchers

Principal Investigators (Australia)

Prof Franz Babl (Royal Children's Hospital; Murdoch Children's Research Institute, Centre for Integrated Critical Care, University of Melbourne)

Dr Elliot Long (Royal Children's Hospital; Murdoch Children's Research Institute, Centre for Integrated Critical Care, University of Melbourne)

Associate Professor Ed Oakley (Royal Children's Hospital; Murdoch Children's Research Institute, Centre for Integrated Critical Care, University of Melbourne)

Principal Investigators (US)

Professor Nate Kupperman (UC Davis Children's Hospital)

Professor Fran Belamuth (Children's Hospital of Philadelphia)

Professor Scott Weiss (Children's Hospital of Philadelphia)

Collaborators

PREDICT Network (Paediatric Research in Emergency Departments International Collaborative)

Royal Children's Hospital, Melbourne

Murdoch Children's Research Institute

Children's Hospital of Philadelphia

UC Davis Children's Hospital

Funding

Medical Research Future Fund ($3,000,000+)

Contact

For enquiries or to register your interest contact fbabl@unimelb.edu.au or Elliot.long@rch.org.au

Research Group

Sepsis


School Research Themes

Integrated Critical Care in Medicine



Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Medicine and Radiology

MDHS Research library
Explore by researcher, school, project or topic.