Regulators of allogeneic stem cell engraftment, graft versus host disease and graft-versus leukaemia
A major component of the curative potential of allogeneic haematopoietic stem cell transplantation (alloHSCT) is the immune mediated graft-versus-leukaemia (GVL) effect. AlloHSCT is limited however by significant toxicity related to conditioning intensity, immunosuppression and associated opportunistic infections and graft-versus host disease (GVHD). Our group aims to understand and apply the efficacy of natural killer (NK) cell biology as both a means of controlling both recipient immunity and residual tumour cells.
We hypothesise that utilising either donor NK cells with enhanced function or limiting recipient NK cell function pre-transplant will allow reduction of conditioning intensity, promote donor T cell engraftment, and promote GVL effects whilst lowering the risks of GVHD.
- Dr Joanne Davis, Postdoctoral Research Officer
- Mrs Mandy Ludford-Menting, Research Assistant
- Dr Nick Huntington, Walter and Eliza Hall Institute of Medical Research, VIC, Australia
- Davis, J. E., Harvey, M., Gherardin, N. A., Koldej, R., Huntington, N., Neeson, P., . . . Ritchie, D. S. (2015). A radio-resistant perforin-expressing lymphoid population controls allogeneic T cell engraftment, activation, and onset of graft-versus-host disease in mice. Biol Blood Marrow Transplant, 21(2), 242-249. doi:10.1016/j.bbmt.2014.11.003.
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