Evaluation of the obesity paradox in diabetes: A longitudinal case-control study of half a million patients

Project Details

Prof. Paul is leading an NHMRC funded large comparative longitudinal case-control study to understand the possible reasons behind the observed “obesity paradox” in patients with type 2 diabetes. This study is based on half-a-million subjects with complete clinical, prescription, medical and event history data from 1990 to 2014, with a median follow-up period of 9 years.


Prof Sanjoy Paul, Director


  • Associate Professor Jonathan Shaw, Baker IDI Heart and Diabetes Institute 
  • Professor Azeem Majeed, Imperial College London, UK 
  • Professor Kamlesh Khunti, University of Leicester, UK 
  • Dr Kerenaftali Klein, University of Queensland


NHMRC Project Grant

Research Outcomes

  1. Paul SK, Shaw JE, Montvida O, Klein K. Weight gain in insulin-treated patients by body mass index category at treatment initiation: new evidence from real-world data in patients with type 2 diabetes. Diabetes, obesity & metabolism. 2016;18(12):1244-52.
  2. Paul SK, Owusu Adjah ES, Samanta M, Patel K, Bellary S, Hanif W, et al. Comparison of body mass index at diagnosis of diabetes in a multi-ethnic population: A case-control study with matched non-diabetic controls. Diabetes, obesity & metabolism. 2017

Research Group

School Research Themes


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Department / Centre


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