Effects of Drugs on Cognition-Related Brain Wave Signals in the Rat
It is increasingly recognised that the rhythmic signals recorded with the electroencephalogram (EEG), or “brain waves” are not just the “noise” of neural activity, but are probably frequency specific channels through which cognition related signalling occurs, including memory encoding. High frequency (“gamma”) brain wave activity has been associated with higher cognitive activity in humans and animals, and is disrupted in psychosis and schizophrenia.
A largely neglected area of study in this area is the role of voltage-gated ion channels that have a significant role in the generation of neuronal and network rhythmicity. In this project, signals related to cognitive processing, including gamma frequency oscillations and place cells will be recorded with microelectrode arrays. The effects of antipsychotic drugs and some related compounds, including potassium and sodium channel modulators, will be examined
This project has considerable potential to reveal how psychoactive drugs work at the whole brain level, and provide clues for better therapies.
- Dr Idrish Ali
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