David O'Neal

Research Overview

Professor David O’Neal leads his own research group based at the University Of Melbourne, Department Of Medicine at St Vincent’s Hospital. He has led studies with significant national and international collaborations involving clinicians, academics and industry. In addition to planning his own investigator- initiated studies he has provided input into study design of commercially sponsored studies which his team has conducted.

The DTRG Mission is to improve the lives of people with diabetes through exceptional research that drives advancement in innovative technologies. Their vision is to be the centre of excellence in Adult Type 1 diabetes technology research in Australia and the leading partner for collaborators, participants, industry and key stakeholders.

Our group received the University of Melbourne 2020 MDHS Award for Excellence in Team-Based Research Programs for working nationally and internationally with and for people living with Type 1 diabetes to improve their health outcomes.

Further information about our research can be found on the DTRG website

Staff

Professor David O’Neal, Head of D.T.R.G Principal  Investigator
Professor Alicia Jenkins, Principal Investigator
Catriona Sims, Project Portfolio Manager
Dr Jean Lu, Clinical Physician (PHD Candidate) 
Dr Melissa Lee, Clinical Physician (PHD)
Dr Barbora Paldus, Clinical Physician (PHD)
Dr  Balasubramanian Krishna Murthy, Clinical Physician
Dr Sunni Yuan, Research Fellow
Varuni Obeyesekere, Scientist
Katie Brown, Clinical Research Co-ordinator
Dr Dale Morrison, Clinical Research Co-ordinator, Exercise Physiologist
Lesley Robinson, Clinical Research Co-ordinator, Credentialed Diabetes Educator
Emma Netzer, Clinical Research Co-ordinator, Credentialed Diabetes Educator
Tess Amoore, Clinical Research Co-ordinator, Credentialed Diabetes Educator 
Hannah Jones, Clinical Research Co-ordinator, Credentialed Diabetes Educator

Collaborators

Funding

Juvenile Diabetes Research Foundation International
Juvenile Diabetes Research Foundation Australia
Helmsley Charitable Trust
St Vincent's Hospital Melbourne Research Endowment Fund

Diabetes Australia Research Program

Research Publications

Morrison D, Zaharieva DP, Lee MH, Paldus B, Vogrin S, Grosman B, Roy A, Kurtz N, O'Neal DN. Comparable Glucose Control with Fast-Acting Insulin Aspart Versus Insulin Aspart Using a Second-Generation Hybrid Closed-Loop System During Exercise. Diabetes Technol Ther. 2022;24:93-101

Trawley S, Stephens AN, McAuley SA, Speight J, Hendrieckx C, Vogrin S, Lee MH, Paldus B, Bach LA, Burt MG, Cohen ND, Colman PG, Davis EA, Holmes-Walker DJ, Jenkins AJ, Kaye J, Keech AC, Kumareswaran K, MacIsaac RJ, McCallum RW, Sims CM, Stranks SN, Sundararajan V, Ward GM, Jones TW, O'Neal DN. Driving with type 1 diabetes: real-world evidence to support starting glucose level and frequency of monitoring during journeys. Diabetes Technol Ther. 2022

Paldus B, Morrison D, Zaharieva DP, Lee MH, Jones H, Obeyesekere V, Lu J, Vogrin S, La Gerche A, McAuley SA, MacIsaac RJ, Jenkins AJ, Ward GM, Colman P, Smart CEM, Seckold R, King BR, Riddell MC, O'Neal DN. A Randomized Crossover Trial Comparing Glucose Control During Moderate-Intensity, High-Intensity, and Resistance Exercise With Hybrid Closed-Loop Insulin Delivery While Profiling Potential Additional Signals in Adults With Type 1 Diabetes. Diabetes care. 2022; 45:194-203

McAuley SA, Trawley S, Vogrin S, Ward GM, Fourlanos S, Grills CA, Lee MH, Alipoor AM, O'Neal DN, O'Regan NA, Sundararajan V, Colman PG, MacIsaac RJ. Closed-Loop Insulin Delivery Versus Sensor-Augmented Pump Therapy in Older Adults With Type 1 Diabetes (ORACL): A Randomized, Crossover Trial. Diabetes Care. 2022; 45:381-390

Kong YW, Venkatesh N, Paldus B, Lee MH, Zhu J, Sawyer M, Chakrabarti A, Uren C, MacIsaac R, Jenkins A, O'Neal DN. Upload and Review of Insulin Pump and Glucose Sensor Data by Adults with Type 1 Diabetes: A Clinic Audit. Diabetes Technol Ther. 2022

Venkatesh N, Astbury N, Thomas MC, Rosado CJ, Pappas E, Krishnamurthy B, MacIsaac RJ, Kay TWH, Thomas HE, O'Neal DN. SARS-CoV-2 as a Potential Cause of Type 1 Diabetes Facilitated by Spike Protein Receptor Binding Domain Attachment to Human Islet Cells: An Illustrative Case Study and Experimental Data. Diabet Med. 2021:e14608

Paldus B, Lee MH, Morrison D, Zaharieva DP, Jones H, Obeyesekere V, Lu J, Vogrin S, LaGerche A, McAuley SA, MacIsaac RJ, Jenkins AJ, Ward GM, Colman P, O'Neal DN. First Randomized Controlled Trial of Hybrid Closed Loop Versus Multiple Daily Injections or Insulin Pump using Self-Monitoring of Blood Glucose in Free-Living Adults with Type 1 Diabetes Undertaking Exercise. Journal of diabetes science and technology. 2021;15:1399-1401

McAuley SA, Vogrin S, Lee MH, Paldus B, Trawley S, de Bock MI, Abraham MB, Bach LA, Burt MG, Cohen ND, Colman PG, Davis EA, Hendrieckx C, Holmes-Walker DJ, Jenkins AJ, Kaye J, Keech AC, Kumareswaran K, MacIsaac RJ, McCallum RW, Sims CM, Speight J, Stranks SN, Sundararajan V, Ward GM, Jones TW, O'Neal DN, Australian JC-LRG. Less Nocturnal Hypoglycemia but Equivalent Time in Range Among Adults with Type 1 Diabetes Using Insulin Pumps Versus Multiple Daily Injections. Diabetes Technol Ther. 2021;23:460-466

Lu JC, Vogrin S, McAuley SA, Lee MH, Paldus B, Bach LA, Burt MG, Clarke PM, Cohen ND, Colman PG, de Bock MI, Jane Holmes-Walker D, Jenkins AJ, Kaye J, Keech AC, Kumareswaran K, MacIsaac RJ, McCallum RW, Roem K, Sims C, Stranks SN, Trawley S, Ward GM, Sundararajan V, Jones TW, O'Neal DN, Australian JC-LRG. Meal-time glycaemia in adults with type 1 diabetes using multiple daily injections vs insulin pump therapy following carbohydrate-counting education and bolus calculator provision. Diabetes Res Clin Pract. 2021;179:109000.

Lee MH, Paldus B, Vogrin S, Morrison D, Zaharieva DP, Lu J, Jones HM, Netzer E, Robinson L, Grosman B, Roy A, Kurtz N, Ward GM, MacIsaac RJ, Jenkins AJ, O'Neal DN. Fast-Acting Insulin Aspart Versus Insulin Aspart Using a Second-Generation Hybrid Closed-Loop System in Adults With Type 1 Diabetes: A Randomized, Open-Label, Crossover Trial. Diabetes care. 2021

Zaharieva D, Teng JH, Ong ML, Lee MH, Paldus B, Jackson L, Holihan CA, Shub A, Tipnis S, Cohen O, O'Neal DN, Krishnamurthy B: Title: Continuous Glucose Monitoring Versus Self-Monitoring of Blood Glucose to Assess Glycemia in Gestational Diabetes. Diabetes Technol Ther 2020; DOI: 10.1089/dia.2020.0073.

Venkatesh N, Paldus B, Lee MH, MacIsaac RJ, Jenkins AJ, O'Neal DN: COVID-19, Type 1 Diabetes Clinical Practice, Research, and Remote Medical Care: A View From the Land Down-Under. Journal of Diabetes Science and Technology 2020, 14:803-4

McAuley SA, Lee MH, Paldus B, Vogrin S, de Bock MI, Abraham MB, Bach LA, Burt MG, Cohen ND, Colman PG, Davis EA, Hendrieckx C, Holmes-Walker DJ, Kaye J, Keech AC, Kumareswaran K, MacIsaac RJ, McCallum RW, Sims CM, Speight J, Stranks SN, Sundararajan V, Trawley S, Ward GM, Jenkins AJ, Jones TW, O'Neal DN, Australian JC-LRG: Six Months of Hybrid Closed-Loop Versus Manual Insulin Delivery With Fingerprick Blood Glucose Monitoring in Adults With Type 1 Diabetes: A Randomized, Controlled Trial. Diabetes Care 2020, 43:3024-33

Lee MH, Vogrin S, Paldus B, Jayawardene D, Jones HM, McAuley SA, Obeyesekere V, Gooley J, La Gerche A, MacIsaac RJ, Sundararajan V, Jenkins AJ, Ward GM, O'Neal DN: Glucose and Counterregulatory Responses to Exercise in Adults With Type 1 Diabetes and Impaired Awareness of Hypoglycemia Using Closed-Loop Insulin Delivery: A Randomized Crossover Study. Diabetes Care 2020, 43:480-3

Zaharieva DP, Messer LH, Paldus B, O’Neal DN, Maahs DM and Riddell MC (2020), Glucose control during physical activity and exercise using closed loop technology in type 1 diabetes, Canadian Journal of Diabetes

Venkatesh N, Paldus B, et al. (2020) COVID-19, Type 1 Diabetes Clinical Practice, Research, and Remote Medical Care: A View From the Land Down-Under., Journal of Diabetes Science and Technology, vol 14, no 4, pp 803-804

Morrison D, et al, (2020), Kinetics of Continuously Measured Interstitial Versus Venous Lactate Following High Intensity Exercise in Adults With Type 1 Diabetes, Diabetes Technology & Therapeutics,  Vol. 22. 140

Zaharieva D, Teng JH, Ong ML, Lee MH, Paldus B, Jackson L, Holihan CA, Shub A, Tipnis S, Cohen O, O'Neal DN, Krishnamurthy B, (2020), Continuining glucose monitoring versus self-monitoring of blood glucose to assess glycemia in gestational diabetes, Diabetes Technol Ther, Apr 23

Paldus B, Lee MH, Jones HM, et Al, (2019), Glucose Control Using a Standard Versus an Enhanced Hybrid Closed Loop System: A Randomized Crossover Study, Diabetes Technol Ther. 21(1):56-58

Paldus B, Zaharieva D, (2019), D-I-Y Pancreas, Diabetes Management Journal May 2019

Lee MH, Vogrin S, Paldus B, et al, (2019), Glucose and Counterregulatory Responses to Exercise in Adults with Type 1 Diabetes and Impaired Awareness of Hypoglycemia Using Closed-Loop Insulin Delivery: A Randomized Crossover Study, Diabetes Care, 43. dc191433. 10.2337/dc19-1433

Lee MH, Vogrin S, Paldus B, et al, (2019), Glucose Control in Adults with Type 1 Diabetes Using Medtronic Prototype Enhanced-Hybrid Closed-Loop System: A Feasibility Study, Diabetes Technol Ther, 21(9):499-506. doi:10.1089/dia.2019.0120

Lee MH, Paldus B, Krishnamurthy B, et al, (2019), The Clinical Case for the Integration of a Ketone Sensor as Part of a Closed Loop Insulin Pump System, J Diabetes Sci Technol. January: 1932296818822986. doi:10.1177/1932296818822986

Paldus B, Lee MH, O’Neal DN, (2018), Insulin Pumps in General Practice, Australian Prescriber, 41. 186-190. 10.18773/austprescr.2018.056.

McAuley SA, de Bock MI, Sundararajan V, Lee MH, Paldus B, Ambler GR, Bach LA, Burt MG, Cameron FJ, Clarke PM, Cohen ND, Colman PG, Davis EA, Fairchild JM, Hendrieckx C, Holmes-Walker DJ, Horsburgh JC, Jenkins AJ, Kaye J, Keech AC, King BR, Kumareswaran K, MacIsaac RJ, McCallum RW, Nicholas JA, Sims C, Speight J, Stranks SN, Trawley S, Ward GM, Vogrin S, Jones TW, O'Neal DN, (2018), Effect of 6 months of hybrid closed-loop insulin delivery in adults with type 1 diabetes: A randomised controlled trial protocol, BMJ open, 8. e020274. 10.1136/bmjopen-2017-020274

Lee MH, Paldus B, O’Neal DN, (2017), Type 1 diabetes and the Artificial Pancreas, Diabetes Management Journal

Research Projects


School Research Themes

Cardiometabolic



Key Contact

For further information about this research, please contact Group Leader Professor David O'Neal

Department / Centre

Medicine

Unit / Centre

David O'Neal

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