Neurotrauma and Stroke
Stoke is a common and serious condition, with few therapies. Whilst previous research has been directed towards preventing the progression of injury during the acute phase, new evidence suggests that targeting brain repair and remodelling may be a better approach for the majority of stroke survivors who live with an ongoing disability.
Our focus is to identify new targets in the brain for promoting brain repair as well as develop new treatment strategies that facilitate functional recovery. In particular current projects centre on the role of the neurovascular unit in brain rescue and include drug therapies to target astrogliosis and epidural electrical stimulation to awaken and reconnect cells for restored nerve transmission.
Working closely with leading clinicians at St Vincent’s Hospital who specialise in brain disorders our team is committed to research that is focused on translation of positive outcomes in animal models to clinical success.
- Dr Carli Roulston, Senior Research Officer (Team leader)
- Dr Mohammad Iqbal Hossain, Post-doctoral Research Officer
- Professor Mark Cook, Chair Of Medicine, University of Melbourne
- Professor Philip Beart, The Florey Institute of Neuroscience and Mental Health
- A/Professor Heung-Chin Cheng, Department Biochemistry, University of Melbourne
- Dr Lauren Sanders, St Vincent's Hospital
- Professor Robert Shepherd, Bionics Institute
- A/Prof Chris Williams, Bionics Institute
- Professor Michael Murphy, St Vincent’s Hospital
- Cass Foundation Science and Medicine Grant
- Brain Foundation Australia
- St Vincent's Hospital Research Endowment Fund
Scholarly Book Chapters
- Chan EC, Liu GS, Roulston CL, Lim SY, Dusting GJ. NADPH oxidase in tissue repair and regeneration. Systems Biology of Free Radicals and Antioxidants, 2014, Editor: Laher I. Springer Publishing, 110: 2517-37.
- Roulston CL, McCann SK, Weston R, Jarrott B. Animal models of stroke for preclinical drug development: A comparative study of flavonols for cytoprotection. Translational Stroke Research: From Target Selection to Clinical Trials, 2012, Editors: Lapchak PA and Zhang JH. Springer Publishing, Part III: Chapter 25:493-524.
Referred Review Articles
- Abeysinghe HCS, Roulston CL. Targeting inflammatory astrocytes to facilitate brain rescue and remodelling. International Journal of Molecular Sciences, 2016; 17(3), 288; doi:10.3390/ijms17030288.
- Hoque, A; Hossain, MI; Ameen, SS; Ang, CS; Williamson, N; Ng, DC; Chueh, AC; Roulston, C; Cheng, HC. A Beacon of Hope in Stroke Therapy - Blockade of Pathologically Activated Cellular Events in Excitotoxic Neuronal Death as Potential Neuroprotective Strategies. Pharmacology and Therapeutics 2016; 160:159-70.
- Roulston CL. Challenges and Pitfalls Associated with Stem Cell Transplants for Stroke. Journal of Neurology and Neurophysiology 2013; 4:5 1000e114.
- McCann SK and Roulston CL. NADPH oxidase as a therapeutic target for neuroprotection against ischemic stroke: Future perspectives. Brain Sciences, 2013; 3: 561-598.
Referred Journal Articles
- Abeysinghe HCS, Bokhari L, Quigley A, Choolani M, Chan J, Dusting GJ, Jeremy CM, Kobayashi N, Roulston CL. Pre-differentiation of human neural stem cells into GABAergic neurons prior to transplant results in greater repopulation of the damaged brain and accelerates functional recovery after transient ischemic stroke. Stem Cell Research & Therapy 2015; 6:186. doi: 10.1186.
- Abeysinghe HCS, Bokhari L, Dusting GJ, Roulston CL. Cyclosporine A reduces glial scarring and facilitates functional recovery following transient focal ischemia. Journal of Neurology and Neurophysiology 2015; 6:100027.
- Hossain MI, Roulston CL, Stapleton DI. Molecular Basis of Impaired Glycogen Metabolism during Ischemic Stroke and Hypoxia. PLoS One 2014; 9(5):e97570.
- McCann S, Dusting GJ, Roulston CL. Nox2 knockout delays infarct progression and increases vascular recovery through angiogenesis in mice following ischaemic stroke with reperfusion. PLoS One 2014; 9(11):e110602.
- Abeysinghe HC, Bokhari L, Dusting GJ, Roulston CL. Brain Remodelling following Endothelin-1 Induced Stroke in Conscious Rats. PLoS One 2014. 9(5):e97007.
- Hossain MI, Roulston CL, Kamaruddin AM, Chu PWY, Ng DCH, Dusting GJ, Bjorge JD, Williamson NA, Fujita DJ, Cheung SN, Hill AF, Cheng HC. A Calpain-truncated Form of Src Protein Kinase is A Key Mediator of Neuronal Death in Excitotoxicity. Journal of Biological Chemistry 2013; 288:9696-709.
- Weston RM, Lin B, Dusting GJ, and Roulston CL. Targeting oxidative stress injury after ischemic stroke in conscious rats: limited benefits with apocynin highlights the need to incorporate long term recovery. Stroke Research and Treatment 2013:648061.
- Taylor CJ, Weston RM, Dusting GJ, and Roulston CL. NADPH oxidase and angiogenesis following endothelin-1 induced stroke in rats: role for Nox2 in brain repair. Brain Sciences 2013; 3:294-317.
- McCann SK, Dusting GJ, Roulston CL. Early Increase of Nox4 NADPH Oxidase and Superoxide Generation Following Endothelin-1-induced Stroke in Conscious Rats. Journal of Neuroscience Research 2008; 86:2524-34.
- Roulston CL, Callaway JK, Jarrott B, Woodman OL, Dusting GJ. Using behaviour to predict stroke severity in conscious rats: post-stroke treatment with 3’, 4’ dihydroxyflavonol improves recovery. European Journal of Pharmacology 2008; 584:100-10.
- Miller AA, Dusting GJ, Roulston CL, Sobey CG. NADPH-oxidase activity is elevated in penumbral and non-ischemic cerebral arteries following stroke. Brain Research 2006; 1111: 111-16.
- Rebooting the brain after stroke with electrical stimulation to promote functional recovery
- Targeting Astrogliosis to promote recovery after stroke
Faculty Research Themes
School Research Themes
For further information about this research, please contact Group Leader Dr Carli L Roulston
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