Rebooting the brain after stroke with electrical stimulation to promote functional recovery
This project is a collaboration between The Bionics Institute and the Department of Medicine, where we will conduct safety and efficacy profiling of a novel monitor-to-stimulator epidural device for recovery of deficits after stroke. The device is a brain implant that can record neural activity after stroke to guide stimulation protocols to regions of the brain where it is required. Additionally, the devise can simultaneously record neural responses to stimulation and thus monitor its effects.
Using this device we will investigate the effects of stimulation on connectivity and signaling pathways to uncover potential mechanisms through which brain stimulation works to promote functional recovery. Whilst these studies will be performed in a relevant animal model of stroke, the information obtained will be used for translation to clinical trial.
This project is supervised by Dr Carli Roulston, and co-supervised by A/Professor Chris Williams (Bionics Institute).
- Professor Mark Cook, Chair of Medicine, St Vincent's Hospital
- Professor Robert Shepherd, Director Bionics Institute
- A/Prof Michael Murphy, St Vincent's Hospital
- Dr Lauren Sanders, St Vincent's Hospital
- Brain Foundation Australia
- St Vincent's Hospital Research Endowment Fund
- Abeysinghe HC, Bokhari L, Dusting GJ, Roulston CL. Brain Remodelling following Endothelin-1 Induced Stroke in Conscious Rats. PLoS One 2014. 9(5):e97007.
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