Vascular Health

Project Details

Cardiovascular disease is the number one cause of death both worldwide and in Australia. It is also the top cause of death in the elderly. Although older women have a higher incidence of cardiovascular disease compared to men, not only do medications that target cardivascular health not benefit women as they do men, but there is lower awareness of vascular health in women compared to men. The Healthy Ageing Program examines several factors that have been linked to vascular health, such as lifestyle factors, body mass index, and physical activity, particularly in relation to women.

Current Healthy Ageing Program projects in Vascular Health include:

  • The relationship of physical activity, body composition and cardivascular risks in older women
  • Lipoproteins and cardivascular risk from mid- to late-life in women
  • Sex hormones and cardivascular disease in post-menopausal women
  • Vitamin D levels and cardiovascular disease
  • The protective effect of statins against dementia-associated cognitive decline


  • Dr Paul Yates
  • Dr Karren Chen
  • Dr Arti Appannah
  • David Thawley
  • Dennis Wang
  • Daniel Watson
  • James Rosewarne
  • Kaman Li
  • Matilda Wright

Research Outcomes

Our research in the media

Research Publications

  • Szoeke, C., Goodwill, A. M., Gorelik, A., Dennerstein, L., Caeyenberghs, K., Simpson Jr, S., ... & Campbell, S. (2019). Apolipoprotein E4 Mediates the Association Between Midlife Dyslipidemia and Cerebral Amyloid in Aging Women. Journal of Alzheimer's Disease, (Preprint), 1-10. doi: 10.3233/JAD-180815
  • Aljondi, R., Szoeke, C., Steward, C., Gorelik, A., & Desmond, P. (2018). The effect of midlife cardiovascular risk factors on white matter hyperintensity volume and cognition two decades later in normal ageing women. Brain imaging and behavior, 1-11. doi: 10.1007/s11682-018-9970-5
  • Goodwill, A. M., Campbell, S., Gorelik, A., & Szoeke, C. (2018). Midlife dyslipidemia combined with the presence of apoe-ε4 is associated with an increased risk of late-life cerebral amyloid-beta. Alzheimer's & Dementia: The Journal of the Alzheimer's Association14(7), P594. doi: 10.1016/j.jalz.2018.06.669
  • Bousman, C. A., Szoeke, C., Chen, K., Dennerstein, L., Henderson, V. W., & Everall, I. P. (2012). Oestrogen alpha-receptor variant and two-year memory decline in midlife Australian women. Neuropsychobiology66(4), 259-265. doi: 10.1159/000341879
  • Chen, K. H., Henderson, V. W., Stolwyk, R. J., Dennerstein, L., & Szoeke, C. (2015). Prehypertension in midlife is associated with worse cognition a decade later in middle-aged and older women. Age and ageing44(3), 439-445. doi: 10.1093/ageing/afv026
  • Ryan, J., Stanczyk, F. Z., Dennerstein, L., Mack, W. J., Clark, M. S., Szoeke, C., ... & Henderson, V. W. (2012). Hormone levels and cognitive function in postmenopausal midlife women. Neurobiology of aging33(3), 617-e11. doi: 10.1016/j.neurobiolaging.2010.07.014
  • Research Group

    Healthy Ageing Program

    Faculty Research Themes


    School Research Themes

    Neuroscience & Psychiatry, Women's Health, Infectious Diseases and Immunity, Musculoskeletal , Cardiometabolic

    Key Contact

    For further information about this research, please contact the research group leader.

    Department / Centre


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