What is the contribution of embryo-endometrial asynchrony to implantation failure?
The synchronized development of a viable embryo and a receptive endometrium are critical for successful implantation to take place. By convention, the time when the blastocyst first attaches and starts to invade into the endometrium, has been defined as the ‘window of implantation’. The term ‘window of implantation’ can be misleading when it is used to imply that there is a single critical window in time that determines whether implantation will be successful or not. Embryo maturation and endometrial development are two independent continuous processes. Implantation occurs when the two tissues fuse and pregnancy is established. A key concept in understanding this event is developmental ‘synchrony’, defined as when the early embryo and the uterus are both developing at the same rate such that they will be ready to commence, and successfully continue implantation at the same time. Many different events including controlled ovarian hyper-stimulation as routinely used in IVF, can potentially disrupt embryo-endometrial synchrony. There is some evidence in humans that implantation rates are significantly reduced when embryo-endometrial development asynchrony is greater than 3 days (+/- 1.5 days).
In these studies, we are …..
- Professor Peter Rogers, Professor of Women's Health Research
- Dr Premila Paiva, Research Fellow
- Dr Wan Tinn Teh, PhD Student
- Professor John McBain, Melbourne IVF
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