Preparing for clincial trials of synchrotron microbeam radiation therapy for cancer treatment
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Microbeam radiation therapy (MRT), using X-rays generated by a synchrotron facility, is a novel, preclinical form of radiotherapy that shows promise of providing a major advance in cancer control if successfully translated to clinical practice. Given that up to 50% of cancer patients receive radiotherapy, and that radiotherapy and surgery remain the major treatment modalities that achieve loco-regional control of cancer, the significance of developing MRT as a new treatment paradigm cannot be understated. In particular, the apparent tolerance of normal tissues to MRT-induced radiotoxicity holds promise of a greatly improved therapeutic index with this treatment modality, opening the way to significantly improved patient outcomes.
These studies will….
The major outcomes of this project will be generation of acute and long-term normal tissue radiation toxicity data using large animal models and development of accurate patient positioning, image guidance and MRT treatment planning systems. We will also continue studies using tumour models to better establish the conditions under which MRT provides optimal anti-tumour effects.
Assoc Prof Jeffrey Crosbie, RMIT
An evaluation of novel real-time technology as a tool for measurement of radiobiological and radiation-induced bystander effects.
Ibahim MJ, Crosbie JC, Paiva P, Yang Y, Zaitseva M, Rogers PA.
Radiat Environ Biophys. 2016 Mar 19. [Epub ahead of print]
The normal tissue effects of microbeam radiotherapy: What do we know, and what do we need to know to plan a human clinical trial?
Smyth LM, Senthi S, Crosbie JC, Rogers PA.
Int J Radiat Biol. 2016 Mar 16:1-10. [Epub ahead of print]
Image guidance protocol for synchrotron microbeam radiation therapy.
Pelliccia D, Poole CM, Livingstone J, Stevenson AW, Smyth LM, Rogers PA, Haüsermann D, Crosbie JC.
J Synchrotron Radiat. 2016 Mar;23(2):566-73. doi: 10.1107/S1600577515022894. Epub 2016 Jan 28.
Eosinophil-Associated Gene Pathways but not Eosinophil Numbers are Differentially Regulated between Synchrotron Microbeam Radiation Treatment and Synchrotron Broad-Beam Treatment by 48 Hours Postirradiation.
Ibahim MJ, Yang Y, Crosbie JC, Stevenson A, Cann L, Paiva P, Rogers PA.
Radiat Res. 2016 Jan;185(1):60-8.
In vitro study of genes and molecular pathways differentially regulated by synchrotron microbeam radiotherapy.
Yang Y, Crosbie JC, Paiva P, Ibahim M, Stevenson A, Rogers PA.
Radiat Res. 2014 Dec;182(6):626-39.
An evaluation of dose equivalence between synchrotron microbeam radiation therapy and conventional broad beam radiation using clonogenic and cell impedance assays.
Ibahim MJ, Crosbie JC, Yang Y, Zaitseva M, Stevenson AW, Rogers PA, Paiva P.
PLoS One. 2014 Jun 19;9(6):e100547.
Reference dosimetry at the Australian Synchrotron's imaging and medical beamline using free-air ionization chamber measurements and theoretical predictions of air kerma rate and half value layer.
Crosbie JC, Rogers PA, Stevenson AW, Hall CJ, Lye JE, Nordström T, Midgley SM, Lewis RA.
Med Phys. 2013 Jun;40(6):062103.
Genome-wide transcription responses to synchrotron microbeam radiotherapy.
Sprung CN, Yang Y, Forrester HB, Li J, Zaitseva M, Cann L, Restall T, Anderson RL, Crosbie JC, Rogers PA.
Radiat Res. 2012 Oct;178(4):249-59.
Microbeam-irradiated tumour tissue possesses a different infrared absorbance profile compared to broad beam and sham-irradiated tissue.
Sharma M, Crosbie JC, Puskar L, Rogers PA.
Int J Radiat Biol. 2013 Feb;89(2):79-87.
In situ biological dose mapping estimates the radiation burden delivered to 'spared' tissue between synchrotron X-ray microbeam radiotherapy tracks.
Rothkamm K, Crosbie JC, Daley F, Bourne S, Barber PR, Vojnovic B, Cann L, Rogers PA.
PLoS One. 2012;7(1):e29853.
Biodosimetric quantification of short-term synchrotron microbeam versus broad-beam radiation damage to mouse skin using a dermatopathological scoring system.
Priyadarshika RC, Crosbie JC, Kumar B, Rogers PA.
Br J Radiol. 2011 Sep;84(1005):833-42.
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