Systems Neuropsychiatry

Research Overview

The Systems Group is a team of neuroscientists, engineers and psychiatrists, who study brain networks in people with mental and neurological disorders, and apply the knowledge gained to engineer improved therapies. Our diverse and interdisciplinary team is based across the Departments of Psychiatry and Biomedical Engineering at the University of Melbourne. The team’s key areas of expertise include clinical neuroimaging, network neuroscience and computational modelling, complex systems, bioinformatics and brain stimulation, particularly in the application of these techniques to the study and treatment of depression, obsessive-compulsive disorder and schizophrenia.

Our team has developed widely used tools to study brain networks and we are committed to training researchers in their use. We host the Australian Connectomics School and our group has contributed expertise and data to numerous international neuroimaging initiatives.

Interested in joining? We welcome applications from graduate students, postdoctoral scholars and visitors. Enquiries should include a brief cover letter and CV.



The group's research is primarily funded by the Australian Research Council (ARC) and the National Health and Medical Research Council (NHMRC). Many researchers in the group are supported by prestigious research fellowships.

Research Opportunities

This research project is available to PhD students, Post Doctor Researchers to join as part of their thesis.
Please contact the Research Group Leader to discuss your options.

Research Publications

TOP 5 publications

Tian Y, Margulies D, Breakspear M, Zalesky A. Topographic organization of the human subcortex unveiled with functional connectivity gradients. Nature Neuroscience. 2020; in press. PubMed

Li A, Zalesky A, et al. A neuorimaging biomarker of striatal dysfunction in schizophrenia. Nature Medicine. 2020; 26:558-565. PubMed

Seguin C, Razi A, Zalesky A. Inferring neural signalling directionality from undirected structural connectomes. Nature Communications. 2019; 10(1):4289. PubMed

Fornito A, Zalesky A, Bullmore E. Fundamentals of Brain Network Analysis. Elseiver. 2016. PubMed

Fornito A, Zalesky A, Breakspear M. The connectomics of brain disorders. Nature Reviews Neuroscience. 2015; 16(3):159-172. PubMed

Research Projects

For project inquiries, contact our research group head.

Faculty Research Themes


School Research Themes

Neuroscience & Psychiatry

Key Contact

For further information about this research, please contact Associate Professor Andrew Zalesky

Department / Centre

Psychiatry , Melbourne Neuropsychiatry Centre

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