The role of the ubiquitin proteasome system in schizophrenia
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Group Leader
Professor Ian Everall+61 3 8344 5509
Project Details
This project is interrogating the ubiquitin proteasome system (UPS) as a potential harbour of biomarkers for schizophrenia and related clinical outcomes such as symptom severity, cognition, and treatment response. Peripheral blood and post-mortem brain tissue are being utilised to examine the UPS using genomic, transcriptomic and proteomic techniques. Neuroimaging is also being utilised to identify associations between peripheral markers and brain structure/function.
Funding
CRC for Mental health
Research Publications
Bousman, C.A., Chana, G, Glatt, S.J., Tatro, E., Chandler, S.D., May, T., Lohr, J., Kremen, W.S., Everall, I.P., Tsuang, M.T. Positive symptoms in psychosis correlate with expression of ubiquitin proteasome genes in peripheral blood. American Journal Medical Genetics Part B: Neuropsychiatric Genetics 2010, 153B: 1336-1341.
Bousman, CA, Chana, G, Glatt, SJ, Chandler, SD, Lucero, GR, Tatro, E, May, T, Lohr, JB, Kremen, WS, Tsuang, MT, Everall, IP. Preliminary evidence of ubiquitin proteasome system dysregulation in schizophrenia and bipolar disorder: convergent pathway analysis findings from two independent samples. American Journal Medical Genetics Part B: Neuropsychiatric Genetics 2010, 153B: 594-602.