Departmental Seminars

Every week on Monday, until 25 Nov 2018
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2018 Seminars Series (no RSVP required)

Next Seminars:

Monday 26 November 2018 - 12.30pm - Level 7, RWH Hospital Seminar Room 7D/E
The role of ageing of mesenchymal stem/stromal cells and their secreted extracellular vesicles in placental pathologies
Ramin Khanabdali, PhD Student, Department of Obstetrics and Gynaecology, The University of Melbourne,
Department of Maternal-Fetal Medicine Pregnancy Research Centre, The Royal Women’s Hospital

Premature ageing is a feature of important placental pathologies. Recent evidence shows a dramatic increase in the risk of unexplained antepartum stillbirths in pregnancies that progress into the late/post-term period (42 weeks gestation and beyond), which may be linked to increased ageing of placenta.
Mesenchymal stem/stromal cells (MSCs) play an important role in the formation of the placenta. However, the contribution of MSCs to the ageing processes in the feto-maternal interface during the period from early-term (37–39 weeks gestation) to late/post-term is unknown. The objective of this study was to investigate stem cell functions and ageing functions of early term and late/post placental MSCs.


MicroRNAs In The Maternal Circulation As Predictors Of Preeclampsia At Term
Monday 3 December 2018 - 1pm - Lecture Theatre, Level 4, Mercy Hospital for Women

Carole-Anne Whigham, PhD Candidate, O&G Registrar
Department of Obstetrics & Gynaecology,The University of Melbourne

Introduction:  MicroRNAs (miRs) are small RNA molecules involved in the negative regulation of genes, that are highly stable within the circulation. Our objective was to screen women at 36 weeks gestation to identify potential microRNA biomarkers of PE.

Methods: A panel of 41 miRs were selected for analysis.  A case-control group was selected from the FLAG cohort comprising n=196 controls and n=34 patients destined to develop PE. Whole blood RNA was extracted to measure miRs at 36 weeks.

Results:We found miRs 149 and 363 are associated with PE, with a sensitivity of 45.5% at a specificity of 90%. Assuming the prevalence of PE at 5%, we find a negative predictive value (NPV) of 97%.

Discussion:Whilst the combined sensitivity of miR149 and 363 is low, the reasonable NPV highlights these miRs as potential contributors to a multi-analyte rule-out test at term.

AND

Potential role of adipose tissue derived exosomes in the pathogenesis of GDM
Monday 3 December 2018 - 1pm - Lecture Theatre, Level 4, Mercy Hospital for Women

Nanthini Jayabalan, PhD Candidate, Department of Obstetrics & Gynaecology
The University of Melbourne

GDM is glucose intolerance diagnosed for the first time during pregnancy with obesity and inflammation proposed as possible causative factors. However, this may not be the full story. Recently, a great interest in the field of extracellular vesicles has been observed in the literature, especially of exosomes. Exosomes act as shuttles to deliver bioactive molecules that alter the biological functions of the recipient cells. Adipose tissue derived exosomes reported to mediate metabolic diseases, including insulin resistance. It is possible adipose tissue-derived exosomes mediate the communication between adipose tissue and placenta, contributing for the development of GDM.


Any queries regarding this seminar, please contact Liliana liliana.donisi@unimelb.edu.au