Graduate Research Degree Awarded - Paul Wood
Congratulations to Paul Wood - Graduate Research Degree Awarded 8 January 2021.
Supervisors: Prof Grant McArthur (Principal), A/Prof David Ashley
Advisory Committee: Dr Andreas Moller (Chair)
Thesis Title: Novel therapeutic approaches to paediatric cancer
Thesis SummaryIn the first two results chapters I have used a combination of human neuroblastoma tissue samples, human and murine cells lines, and the TH-NMYC neuroblastoma mouse model to investigate both the role of the PI3K/mTOR pathway in neuroblastoma by using inhibitors of this pathway, and epigenetically driven terminal differentiation using histone deactylase inhibitors. In the final results chapter, I present a Phase I clinical trial of panobinostat in paediatric patients with relapsed solid tumours that I fully conducted and published.
Date awarded: 8 January 2021