Janine Trevillyan

Research Overview

A/Prof Trevillyan’s group is a translational clinical trial team that investigates the pathogenesis and prevention of the long-term complications of HIV. Specifically, this work focuses on understanding the physiological basis for weight gain associated with antiretroviral therapy and identifying novel pharmacological interventions to reduce accelerated aging and age-related diseases (such as cardiovascular disease) in people living with HIV.

The group has also recently expanded to include clinical trials and large scale biobanking investigating the effectiveness and sides effects of new, and renewed vaccines.

Staff

  • Morgan Henri (Research Assistant)

Collaborators

  • Doherty Institute: Lewin Group
  • Alfred Health: Hoy Research Group
  • RMIT: Jaworowski Lab
  • AIDS Clinical Trials Group (ACTG): University of California, Los Angeles Clinical Research Site (Currier)

Funding

    • Victorian State Government - Department of Jobs, Precincts and Regions: The Victorian Critical Vaccinees Collection (VC2)

Research Outcomes

Research Publications

  1. Hearps AC, Angelovich TA, Trevillyan JM, Wong ME, Calmy A, Hoy JF, et al. Effect of Rosuvastatin Therapy on Biomarkers of Inflammation and Immune Activation in People With Human Immunodeficiency Virus at Intermediate Cardiovascular Risk. J Infect Dis 2021; 224(4):667-672.
  2. Trevillyan JM, Dart A, Paul E, Cavassini M, Fehr J, Staehelin C, Dewar EM, Hoy JF, Calmy A. Impact of rosuvastatin on atherosclerosis in people with HIV at moderate cardiovascular risk; a randomised, controlled trial. AIDS. 2021;35(4),619-624
  3. Trevillyan JM, Moser CM, Currier S and Sallam TS. Immune Biomarkers in the Prediction of Future Myocardial Infarction in People with HIV. Clinical Infectious Diseases 2020;70(8):1764-1767
  4. Godfrey C, Bremer A, Alba D… Trevillyan J, Palmer C, Grinspoon S. Obesity and Fat Metabolism in HIV-infected Individuals: Immunopathogenic Mechanisms and Clinical Implications. J Infect Dis. 2019. PMID.30893434
  5. Woolnough EL, Hoy JF, Cheng AC, …. Trevillyan JM. Predictors of chronic kidney disease and utility of risk prediction scores in HIV-positive individuals. AIDS. 2018;32(13):1829-35. PMID.29847332
  6. Trevillyan JM, Arthur JF, Jing J, Andrews RK, Gardiner EE, Hoy JF. Effects of abacavir administration on structural and functional markers of platelet activation. AIDS. 2015;29(17):2309-13. PMID.26544702.

Research Projects

This Research Group doesn't currently have any projects



Faculty Research Themes

Infection and Immunology



Key Contact

For further information about this research, please contact Associate Professor Janine Trevillyan

Department / Centre

Infectious Diseases

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