Jason Trubiano

• 
  Professor
  Jason Trubiano

  trubianoj@unimelb.edu.au

  View researcher's webpage

Research Overview

Professor Trubiano’s research group, the Centre for Antibiotic Allergy and Research, aims to define the impacts of antibiotic allergy and benefits of antibiotic allergy testing on patient care and health services. The group has validated several point-of-care penicillin allergy decision tools, which are currently being deployed in health services interventions or international multicentre randomised control trials, led by the group's PhD candidates. This work seeks to develop sustainable drug allergy programs that improve antibiotic utilisation and drive antimicrobial stewardship policy. The group has recently commenced work on a national penicillin allergy database (https://antibioticallergy.org.au/naan) via the National Antibiotic Allergy Network to assess the Australian impact of hospital de-labelling programs.

The group also works in the translational space of drug allergy, investigating the epidemiology, immunopathogenesis, genomic predictors and diagnostics in Severe Cutaneous Adverse Reactions – A heterogenous group of T-cell mediated drug hypersensitivities. The group has led the development of novel T-cell diagnostics and provided the roadmap for antibiotic pharmacogenomic discovery, in collaboration with colleagues at Vanderbilt University. The group leads the Australasian Registry of Severe Cutaneous Reactions (AUS-SCAR) – a national biobank for SCAR.

Staff

• Fiona James (Research Manager)
• Dr Ana Copaescu (PhD candidate)
• Dr Joseph Deluca (PhD Candidate)
• Dr Morgan Rose (PhD Candidate)
• Effie Mouhtouris (Research Assistant)
• Sara Vogrin (Statistician)
• Dr Natasha Holmes (Clinician Researcher)
• Dr Kyra Chua (Clinician Researcher)
• Elise Mitri (Project Manager)

Collaborators

• Laura MacKay Lab (Doherty)
• Institute for Immunology and Infectious Diseases (Murdoch University)
• Centre for Drug Safety and Immunology (Vanderbilt University)

Funding

• NHMRC EL2 Fellowship

Research Publications

1. Trubiano JA. Antimicrobial allergy 'labels' drive inappropriate antimicrobial prescribing: lessons for stewardship. J Antimicrob Chemother. 2016;71(6):1715-22.
2. Trubiano JA et al. Impact of an Integrated Antibiotic Allergy Testing Program on Antimicrobial Stewardship: A Multicenter Evaluation. Clin Infect Dis. 2017;1;65(1):166-174.
3. Chua KYL...Trubiano JA. The Penicillin Allergy Delabeling Program: A Multicenter Whole-of-Hospital Health Services Intervention and Comparative Effectiveness Study. CID. 2021;73(3):487.
4. Trubiano JA et al. Development and Validation of a Penicillin Allergy Clinical Decision Rule. JAMA Intern Med. 2020;1;180(5):745-752.
5. Trubiano JA. The Combined Utility of Ex Vivo IFN-γ Release ELISpot Assay & In Vivo Skin Testing in Patients with Antibiotic-Associated SCAR. J Allergy Clin Immunol Pract. 2018;6(4):1287.
6. Blumenthal KG, Peter JG, Trubiano JA, Phillips EJ. Antibiotic Allergy. Lancet. 2019; 12;393(10167):183-198.