Prashanth Ramachandran

• Prashanth Ramachandran

  Dr

  pramachandra@unimelb.edu.au
  

Research Overview

The Ramachandran Lab develops innovative and novel diagnostic assays for neuroinflammatory conditions. Their work aims to improve patient care through cost-effective CSF testing, particularly benefiting low-resource settings.

They are a translational laboratory bridging clinical medicine and scientific innovation to develop novel diagnostic tools for neuroinflammatory conditions. Their research aims to understand the underlying mechanisms and pathology of these disorders through advanced technologies. They utilise metagenomic next-generation sequencing, targeted pathogen enrichment, host transcriptomics, aneuploidy detection, and phage immunoprecipitation sequencing to create comprehensive diagnostic solutions. Their integrated approach combines cutting-edge molecular techniques with clinical expertise to advance patient care and improve diagnostic outcomes.

Staff

• Dr Eike Steinig Postdoctoral Fellow
• Dr Andrew Duncan PhD Student
• Ivana Savic PhD Student
• Marcelina Krysiak Research Assistant
• Kirti Deo Research Assistant
• Louis David Hanna MD Scholar Student

Funding

• NHMRC
• Internal Doherty
• Philanthropic Funding

Research Publications

1. RAMACHANDRAN PS, et al. Nat Commun. 2022. PMID: 35354815Integrating central nervous system metagenomics and host response for diagnosis of tuberculosis meningitis and its mimics
2. RAMACHANDRAN PS, et al. JAMA Neurol. 2024.Multiomic analysis of neuroinflammation and occult infection in sudden infant death syndrome
3. Schubert RD, Hawes IA*, RAMACHANDRAN PS*, et al. Nat Med. 2019.Pan-viral serology implicates enteroviruses in acute flaccid myelitis
4. RAMACHANDRAN PS, et al. Neurol Neuroimmunol Neuroinflamm. 2023.Complement Factor I Gene Variant as a Treatable Cause of Recurrent Aseptic Neutrophilic Meningitis
5. RAMACHANDRAN PS, Wilson MR. Metagenomics for neurological infections - expanding our imagination. Nat Rev Neurol. 2020 Jul 13. PMID: 32661342.