Advanced high-resolution diffusion techniques in evaluating brain structure and function after acute ischemic stroke.

Project Details

Stroke is the most frequent cause of permanent disability in adults worldwide. Measurement of the infarction core volume measured using diffusion-weighted magnetic resonance imaging (DWI) has shown to be associated with a greater chance of favourable outcome. Unfortunately, it not currently possible with standard MRI imaging to distinguish between potentially salvageable lesion from irreversibly damaged infarction core. Diffusion-kurtosis imaging (DKI), a relatively new technique,  may reveal the most severely injured portion of the DWI-based lesion. In this study, we are trying to assess the relationship between DWI and DKI imaging in patients with acute stroke within 12 hours after endovascular clot retrieval as well as establish its relationship to cerebral perfusion and white matter lesion load.

Diffusion MRI image of a patient 24 hours after an ischemic stroke. The Red region shows the infarct core measured with DWI, and the blue region with DKI.

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