Trajectory of MR Imaging-derived Oxygen Metabolism in stroke after thrombectomy

Project Details

Ischemic stroke is one of the leading causes of morbidity and mortality. Endovascular clot retrieval is effective in restoring blood flow, but not all patients have a favourable response, despite reperfusion of the injured tissue and tissue at risk. The goal of this study is to understand how brain cells recover from ischemia. This project will focus on validation of MRI-based quantitative oxygen consumption measured using quantitative susceptibility mapping technique and to understand the trajectory of these measures after successful and partial reperfusion attempts. This will be a major step towards discovering new approaches that could potentially lead to better recovery for more stroke patients.

A representative images of acute ischemic stroke with 18h between MRI examination and stroke symptom onset (Zhang et al 2020).

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