PhD Completion Seminar: Dr Steven McGuigan

PhD Completion Seminar: Dr Steven McGuigan

Title: Identifying the cellular and network level mechanisms responsible for xenon anaesthesia and neuroprotection

Abstract:

The mechanisms underlying anaesthetic-related neural injury, neuroprotection and general anaesthesia remain unresolved. The aim of this research was to identify clinically relevant cellular and network level mechanisms of xenon anesthesia and neuroprotection. We utilized neural injury biomarkers, electroencephalogram analysis and computational modelling of neurons in a clinical and volunteer cohort receiving xenon anaesthesia. We identified unique spectral features in the electroencephalogram during xenon administration with implications for monitoring of xenon anaesthesia. We also identified, through modelling, likely cellular level mechanisms of xenon that are consistent with electroencephalogram features observed during its administration.

Committee Chair: Professor David Story

Principal Supervisor: Professor David Scott

When: Wed 21st Feb 2024

Time: 7:00 - 8:00 am

Venue: Trescowthwick Lecture Theatre, Ground Floor, Main Building, St. Vincent's Hospital, Melbourne