Revolutionising Chemotherapy: Personalised Dosing for Better Cancer Care
Explore the journey of Dr.Justin Yeung, colorectal surgeon, as he shares insights on revolutionising chemotherapy dosing to combat overdosing and toxicities in colorectal cancer treatment. Learn about the innovative approach grounded in body composition and patient characteristics, driven by a commitment to personalised care and a vision for broader applications across various medical treatments.
What problem did you set out to solve?
Chemotherapy dosing currently is very crude. It's based on body surface area rather than body makeup. You can have two people of the same body surface area. One is a sumo wrestler, one is a gym enthusiast. Clearly they have different body makeup and body composition. Their body composition is a major determinant of how drugs are metabolised and that's why they're frequently overdosed or potentially underdosed if they continue to be dosed based on body surface area. There is no clinical methodology or toolkit that we can currently use that will allow us to predict overdosing or toxicities. And our innovation is being able to use body composition and patient characteristics to be able to predict this.