Clinical Diabetes and Epidemiology Group

Research Overview

The Clinical Diabetes and Epidemiology group has two main focuses.

The first relates to the epidemiology of type 2 diabetes, examining trends in prevalence and incidence of diabetes (predominantly type 2) in Australia as well as the rest of the world. The work in this area, pioneered by Professor Paul Zimmet, has been instrumental in demonstrating the rapid growth of the emerging global diabetes epidemic. The surveys undertaken for this work also provide rich data for interrogating a range of putative and novel risk factors for diabetes and its complications, of which lifestyle factors have been studied extensively and remain an important target. The group also has a specific interest in the impact of diabetes on indigenous populations.

The second focus capitalises on the large patient population in our Diabetes Clinic. This facilitates examination of novel treatments, and of observational data on real world responses to therapies.

Research Focus

  • Trends in diabetes prevalence and incidence.
  • Identifying novel risk factors for type 2 diabetes and its complications at a population level.
  • Diabetes and indigenous health.
  • Novel therapies for diabetes.

Staff

Collaborators

  • La Trobe University
  • Monash University
  • Deakin University
  • Centre for Eye Research Australia
  • Australian Centre for Behavioural Research in Diabetes

Funding

  • National Health and Medical Research Council (NHMRC)
  • Centers for Disease Control

Research Opportunities

This research project is available to PhD students, Honours students to join as part of their thesis.
Please contact the Research Group Leader to discuss your options.

Research Publications

1.         Sacre J, Magliano DJ, Shaw JE. Heart failure hospitalisation relative to major atherosclerotic events in type 2 diabetes with versus without chronic kidney disease: a meta-analysis of cardiovascular outcomes trials. Diabetes & Metabolism. 2021;17;101249

2.         Magliano DJ, Chen L, Islam RM, Carstensen B, Gregg EW, Pavkov ME, Andes LJ, Balicer R, Baviera M, Boersma-van Dam E, Booth GL, Chan JCN, Chua YX, Fosse-Edorh S, Fuentes S, Gulseth HL, Gurevicius R, Hwa Ha KH, Hird TR, Jermendy G, Khalangot MD, Kim DJ, Kiss Z, Kravchenko VI, Leventer-Roberts M, Lin CY, Luk AOY, Mata-Cases M, Mauricio D, Nichols GA, Nielen MM, Pang D, Paul SK, Pelletier C, Pildava S, Porath A, Read SH, Roncaglioni MC, Ruiz PLD, Shestakova M, Vikulova O, Wang KL, Wild SH, Yekutiel N, Shaw JE. Trends in the incidence of diagnosed diabetes: a multicountry analysis of aggregate data from 22 million diagnoses in high-income and middle-income settings. Lancet Diabetes Endocrinol. 2021;9(4):203-211

3.         Radavelli-Bagatini S, Anokye R, Bondonno NP, Sim M, Bondonno CP, Stanley MJ, Harms C, Woodman R, Magliano DJ, Shaw JE, Daly RM, Hodgson JM, Lewis JR, Blekkenhorst LC. Association of habitual intake of fruits and vegetables with depressive symptoms: the AusDiab Study. 2021. European Journal of Nutrition. doi: 10.1007/s00394-021-02532-0. [Epub ahead of print]

4.         Sacre JW, Harding JL, Shaw JE* Magliano DJ* [*Joint senior authors] Declining mortality in older people with type 2 diabetes masks rising excess risks at younger ages: A population-based study of all-cause and cause-specific mortality over 13 years. International Journal of Epidemiology.  2021. doi: 10.1093/ije/dyaa270. [Epub ahead of print]

5.         The Lancet Commission on diabetes: using data to transform diabetes care and patient lives. The Lancet Commissions 2021 Dec 19;396(10267):2019-2082

6.         Morton J, IlomÓ“ki J, Magliano DJ, Shaw JE. The Association of Socioeconomic Disadvantage and Remoteness with Receipt of Type 2 Diabetes Medications in Australia: A Nationwide Registry Study. Diabetologia. 2021 Feb;64(2):349-360.

7.         Sacre JW, Magliano DJ, Shaw JE. Incidence of Hospitalization for Heart Failure Relative to Major Atherosclerotic Events in Type 2 Diabetes: A Meta-analysis of Cardiovascular Outcomes Trials. Diabetes Care. 2020 Oct;43(10):2614-2623

8.         Morton JI, Liew D, McDonald SP, Shaw JE*, Magliano DJ* [*Joint senior authors]. The Association Between Age of Onset of Type 2 Diabetes with Long-term Risk of End Stage Kidney Disease: A National Registry Study. Diabetes Care. 2020;43(8):1788-1795.

9.         Chen L, Islam RM, Wang J, Hird TR, Pavkov ME, Gregg EW, Salim A, Tabesh M,  Koye DN, Harding JL, Sacre JW, Barr ELM, Magliano DJ*, Shaw JE* [*Joint senior authors] A systematic review of trends in all-cause mortality among people with diabetes. Diabetologia. 2020;63(9):1718-1735

10.       Magliano DJ, Sacre J, Harding J, Gregg E, Zimmet P, Shaw JE, Young-onset type 2 diabetes mellitus — implications for morbidity and mortality. Nature Reviews Endocrinology. 2020;16(6):321-331

11.       Buyadaa O, Magliano DJ, Salim A, Koye DN, Shaw JE. Risk of Rapid Kidney Function Decline, All-Cause Mortality, and Major Cardiovascular Events in Nonalbuminuric Chronic Kidney Disease in Type 2 Diabetes. Diabetes Care. 2020 ;43(1):122-129

12.       Magliano DJ, Islam RM, Barr ELM, Gregg EW, Pavkov ME, Harding JL, Tabesh M, Koye DN, Shaw JE. Trends in incidence of total or type 2 diabetes: systematic review. BMJ. 2019;366:l5003.

13.       Koye, DN, Magliano DJ, Reid, CM, Pavkov ME, Chadban SJ, McDonald SP, Polkinghorne KR, White S, Paul C & Shaw JE. Trends in Incidence of ESKD in People with Type 1 and Type 2 Diabetes in Australia, 2002-2013. American Journal of Kidney Diseases. 2019;73(3):300-308.

Research Projects

For project inquiries, contact our research group head.

School Research Themes

Cardiometabolic


Key Contact

For further information about this research, please contact Deputy Director (Clinical and Population Health), Baker Institute Professor Jonathan Shaw

Department / Centre

Baker Department of Cardiometabolic Health Research

Unit / Centre

Clinical Diabetes and Epidemiology Group Cardiac Cellular Systems

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