Cardiometabolic

The School has a varied and strong research history into cardiometabolic diseases, covering conditions including diabetes, obesity, heart disease and different cardiac pathologies.  We conduct cutting-edge research, translating into practical outcomes through our strong links and embedding within leading hospitals in Melbourne, with many of our leading researchers also being clinical practitioners allowing them to directly apply their research in their clinical practice.

Groups / Projects Research Lead Dept / Centre
: Unravelling the role of breast milk ether lipids in modulating immune function in early life Professor Peter Meikle Baker Department of Cardiometabolic Health
A monoclonal antibody (mAb1F5) has been developed that identifies a unique marker, a membrane protein expressed by pericytes and meningeal cells Dr Peter Wookey Medicine
A New reagent for detection of program cell death Dr Peter J Wookey Medicine
A novel approach in improving lipidomics throughput for population profiling Professor Peter Meikle Baker Department of Cardiometabolic Health
Activated platelets targeted drug therapy Dr Xiaowei Wang Baker Department of Cardiometabolic Health
Additional Signals Project Lead Professor David O'Neal Medicine
Adult Hybrid Closed Loop Study Project Lead Professor David O'Neal Medicine
An anti-calcitonin receptor (CTR) antibody for detection of programmed cell death: the role of CTR in a novel adaptive response to cell stress Dr Peter Wookey Medicine
An antibody (mAb2E1) that detects a novel, high molecular weight surrogate ligand of calcitonin receptor is detected in malignant glioma cells, developing brain and bone, and an osteosarcoma cell line Dr Peter J Wookey Medicine
An antibody that detects a high molecular weight surrogate ligand of calcitonin receptor is detected in malignant glioma cells and cell lines. Dr Peter J Wookey Medicine
Application of computational biology approaches to identify and develop biomarkers to predict pregnancy disorders and guide clinical practice. Professor Eva Dimitriadis Obstetrics and Gynaecology
Arterial grafting for coronary artery revascularisation Co-director Colin Royse
Surgery
Artificial intelligence system to detect eye and cardiovascular diseases Professor Mingguang He Surgery
Assessing the therapeutic effects of plasmalogen supplementation in a mouse model of heart failure Dr Yow Keat Tham Baker Department of Cardiometabolic Health
Atherothrombosis and Vascular Biology Group Head of Laboratory Professor Karlheinz Peter Peter
 Baker Department of Cardiometabolic Health
Baker Department of Cardiometabolic Health Research Baker Department of Cardiometabolic Health
Darren Kelly Group Leader Professor Darren Kelly
Medicine
Brain storming therapeutics for neurodegeneration with novel research models A/Prof Brian Drew Baker Department of Cardiometabolic Health
Cardiac Cellular Systems Laboratory Head Dr Alexander Pinto
 Baker Department of Cardiometabolic Health Research
Cardiac Hypertrophy Group Head of Laboratory Professor Julie McMullen
Baker Department of Cardiometabolic Health
Cardiothoracic Surgery Professor Alistair Royse
Surgery
Cardiovascular and Tumourivascular Laboratory Dr Peter J Wookey
Professor David Hare 		Medicine
Cardiovascular Inflammation and Redox Biology Head of Laboratory Professor Judy de Haan
 Baker Department of Cardiometabolic Health
Cellular and Molecular Mechanisms Driving Anthracycline-Induced Cardiotoxicity in Children Dr Alexander Pinto Baker Department of Cardiometabolic Health
Cellular and Molecular Mechanisms Driving Anthracycline-Induced Cardiotoxicity in Children Dr Alexander Pinto Baker Department of Cardiometabolic Health
Chronic Kidney Disease in the Management of people with Type 2 Diabetes in General Practice Project Leader Dr Jo-Anne Manski-Nankervis General Practice
Clinical Diabetes and Epidemiology Group Deputy Director (Clinical and Population Health), Baker Institute Professor Jonathan Shaw
 Baker Department of Cardiometabolic Health Research
Cognitive Health Project Leader Professor Cassandra Szoeke Medicine
Common severe childhood infections, innate inflammatory responses and cardiometabolic risk: The VASCular changes aFter INfectious Diseases (VASCFIND) study Prof David Burgner Paediatrics
Detecting the tissue of origin of circulating cell free DNA Professor Lachlan Coin Clinical Pathology
Developing nanoparticles for targeted theranostics delivery of drug and gene therapeutics Dr Xiaowei Wang Baker Department of Cardiometabolic Health
Developing platelet derived nanoparticles for targeted thrombolysis Prof Karlheinz Peter Baker Department of Cardiometabolic Health
Development and validation of a high throughput clinical lipidomics platform Professor Peter Meikle Baker Department of Cardiometabolic Health
Development of novel therapeutics to prevent or treat preeclampsia Associate Professor Natalie Hannan
Obstetrics and Gynaecology
Diabetes and Cardio-Metabolic Conditions Research Program Leader Professor John Furler
General Practice
Diabetes Discovery - prevalence and outcomes in inpatients with diabetes Project Leader Dr Elif Ekinci Medicine
David O'Neal Group Leader Professor David O'Neal
Medicine
Laima Brazionis Group Leader Dr Laima Brazionis
Medicine
Diagnosis and therapy of inflammatory diseases using molecular ultrasound imaging Dr Xiaowei Wang Baker Department of Cardiometabolic Health
Chris Ryan Group Leader Chris Ryan
 Medicine
Do short chain fatty acids prevent gut leakiness and enhanced haematopoiesis induced by a high salt diet? Prof Andrew Murphy Baker Department of Cardiometabolic Health
Does epicardial adipose tissue contribute to atrial fibrillation in endurance athletes? Dr Erin Howden Baker Department of Cardiometabolic Health
Drug development for metabolic diseases A/Prof Jon Oakhill Medicine
Dyslipidemia Decision Support Medicine
Emerging Infectious Diseases and Travel Medicine Research Group Leader Dr Irani Thevarajan
Infectious Diseases
Engineering a tissue flap Dr Geraldine Mitchell Surgery
Exploring how a high salt diet promotes bone destruction through immune cell activation Prof Andrew Murphy Baker Department of Cardiometabolic Health
Exploring how diabetes causes increased proliferation of haematopoietic stem cells carrying a mutation in DNMT3A Prof Andrew Murphy Baker Department of Cardiometabolic Health
Exploring the contribution of intrinsic lipids to immune cell development and function Professor Andrew Murphy Baker Department of Cardiometabolic Health
Exploring the therapeutic potential of protein phosphatases in cardiometabolic disease Dr Kate Weeks Baker Department of Cardiometabolic Health
Factors that determine islet antigen-specific T cell expansion before the onset of Type 1 diabetes Prof Helen Thomas Medicine
Future Health Today Changing the course of cardiovascular disease Associate Professor Jo-Anne Manski-Nankervis General Practice
Gene signatures of the ‘lymphaticome’ Dr Ramin Shayan
Dr Tara Karnezis 		Surgery
Genomics of asthma mortality due to thunderstorm asthma Prof Jo Douglass Medicine
Haematopoesis and Leukocyte Biology Group Head of Laboratory Associate Professor Andrew Murphy
Baker Department of Cardiometabolic Health
Heart Health in Women: Role of Physical Activity to Prevent Cardiovascular Disease Dr Erin Howden Baker Department of Cardiometabolic Health
Human Integrative Physiology Head of Laboratory Dr Erin Howden
Baker Department of Cardiometabolic Health
Identification of additional markers of ferroptosis with mass spectrometry Professor Peter Meikle Baker Department of Cardiometabolic Health
Identifying circadian clock and mineralocorticoid receptor (MR) interactions in heart disease Associate Professor Morag Young Baker Department of Cardiometabolic Health
Imaging Project Leader Monique Stagnitti Medicine
Immunity, Chronic Inflammation and Cardiovascular Disease Professor Karlheinz Peter Baker Department of Cardiometabolic Health
Inhibition of microglia inflammation by AMPK for obesity treatment Dr Sandra Galic Medicine
Integration of population level ‘omics data to target cardiometabolic disease Professor Peter Meikle Baker Department of Cardiometabolic Health
Investigating a novel mechanism for improving beta-cell function in type 2 diabetes Dr Kim Loh Medicine
Investigating cardiovascular disease in Friedreich's ataxia using human induced pluripotent stem cells Dr Shiang (Max) Lim Surgery
Irani Thevarajan Dr Irani Thevarajan
 Infectious Diseases
Lifestyle and Prevention Project Leader Dr Edward Hill Medicine
Lifestyle Factors and Cognitive Health Professor Cassandra Szoeke Medicine
Lipid Metabolism and Cardiometabolic Disease Group Head of Laboratory Associate Professor Anna Calkin
Baker Department of Cardiometabolic Health
Lipidomic Profiling of Atrial Fibrillation Progression in a Murine Model Dr Yow Keat Tham Baker Department of Cardiometabolic Health
Lipoproteins and Cardiovascular Risk from Mid- to Late-life in Women Senior Research Fellow Alexandra Gorelik Medicine
Management of acute decompensated heart failure in inpatients with diabetes Project Leader Dr Elif Ekinci Medicine
Mechanotransduction in blood cells and consequences for thrombosis and inflammation Professor Karlheinz Peter Baker Department of Cardiometabolic Health
Mental Health Project Leader Professor Lorraine Dennerstein Medicine
Metabolomics Group Head of Laboratory Professor Peter Meikle
Baker Department of Cardiometabolic Health
Mineralocorticoid receptor activation pathways in macrophages ; new mechanisms of heart failure Associate Professor Morag Young Baker Department of Cardiometabolic Health
Modelling cardiovascular diseases using human cardiac organoids Doctor Shiang Lim Surgery
Molecular Imaging and Theranostics Group Head of Laboratory Dr Xiaowei Wang
Baker Department of Cardiometabolic Health
Molecular Metabolism and Ageing Group Head of Laboratory Associate Professor Brian Drew
Baker Department of Cardiometabolic Health
Multimorbidity in Ageing Project Leader Dr Kate Gregorevic Medicine
Multimorbidity and glycaemia in people with type 2 diabetes attending Australian general practice: a cross-sectional study utilising data from NPS MedicineInsight Principal Investigator A/Prof Jo-Anne Manski-Nankervis General Practice
Musculoskeletal and Bone Health Project Leader Dr Raquel Pedrero-Chamizo Medicine
Non-alcoholic fatty liver disease – characterising disease features in order to develop new therapies Dr Amanda Edgley Medicine
Novel regenerative therapies in cardiovascular diseases Prof Karlheinz Peter Baker Department of Cardiometabolic Health
Novel therapies for atherosclerotic plaque stabilization Prof Karlheinz Peter Baker Department of Cardiometabolic Health
Novel therapies for the treatment of cardiorenal disease Project Lead Dr Andrew Kompa Medicine
Novel therapies for the treatment of cardiorenal syndrome Dr Andrew Kompa Medicine
Novel therapies for the treatment of cardiovascular disease Professor Darren Kelly
Project Lead Dr Amanda Edgley 		Medicine
Nuclear receptor co-regulators in heart disease and inflammation; new targets for fine-tuning receptor actions in health and disease Associate Professor Morag Young Baker Department of Cardiometabolic Health
Priya Sumithran Dr Priya Sumithran
 Medicine
Plasmalogen modulation as a therapeutic approach for fatty liver disease Professor Peter Meikle Baker Department of Cardiometabolic Health
Point of Care Ultrasound Simulation Education Dr David Canty Surgery
Preclinical Disease and Prevention Head of Laboratory Associate Professor Melinda Carrington
Baker Department of Cardiometabolic Health
Quality of Life Project Leader Dr Katherine Campbell Medicine
Data interoperability for remote patient monitoring Medicine
Artificial Intelligence-assisted Retinal Photography Medicine
Sex and the broken heart: sex-specific mechanisms driving heart failure Dr Alexander Pinto Baker Department of Cardiometabolic Health
SMS Diabetes Education Medicine
Sympathetic activation in adults with inadequate sleep Dr Stephanie Yiallourou Baker Department of Cardiometabolic Health
Targeting inflammation and fibrosis for the treatment of retinal disease Dr Roy Kong Medicine
Targeting Pyroptosis to improve diabetic cardiovascular disease. Prof Judy de Haan Baker Department of Cardiometabolic Health
The cellular fuel gauge: Novel mechanisms of metabolic control A/Prof Jon Oakhill Medicine
The characterisation of CT Receptor expression in the CNS and perinatal PNS: the distribution, intracellular associations and functions of isoforms. Dr Peter J Wookey Medicine
The development of anti-NPY1 receptor antibodies for research into and treatment of cardiovascular diseases and cancer Dr Peter J Wookey Medicine
The development of anti-NPY1 receptor antibodies for research into and treatment of cardiovascular diseases and cancer. Dr Peter J Wookey Medicine
The effect of ageing and sex differences on heart recovery following a heart attack Associate Professor Anna Calkin Baker Department of Cardiometabolic Health
The GP-OSMOTIC trial: Continuous Glucose Monitoring in Type 2 Diabetes Project Leader Associate Professor John Furler General Practice
The role of AMP-activated kinase in suppressing atherosclerosis Dr Kim Loh Medicine
The treatment of the brain tumour glioblastoma (GBM): the efficacy of immunotoxin derived from anti-calcitonin receptor antibodies Dr Peter J Wookey Medicine
Trans Health Research Dr Ada Cheung
 Medicine
Transoesophageal echoardiography in cardiac surgery Co-director Colin Royse
Surgery
Treating fibrosis and inflammation to prevent end-organ damage in diabetes Dr Roy Kong Medicine
Type I interferon as a novel endogenous trigger of trained immunity Dr Andrew Fleetwood Baker Department of Cardiometabolic Health
Ultrasound Education Group Co-director Professor Colin Royse
Co-director Professor Alistair Royse 		Surgery
Understanding antibiotic prescribing and use of guidelines in general practice – the GP National Antimicrobial Prescribing Survey (GP NAPS) pilot study Principal Investigator Dr Jo-Anne Manski-Nankervis General Practice
Understanding how Type 17 immunity and IL-17 cytokines regulate Type 1 diabetes Dr Andrew Sutherland Medicine
Understanding the role of the circadian molecular clock in the development of dilated cardiac myopathy and atrial fibrillation. Associate Professor Morag Young Baker Department of Cardiometabolic Health
Understanding the role of the mineralocorticoid receptor in diabetic cardiac myopathy? Associate Professor Morag Young Baker Department of Cardiometabolic Health
Unravelling the causes of persistent exercise intolerance in cancer survivors Dr Steve Foulkes Baker Department of Cardiometabolic Health
Using the JAK1/JAK2 Inhibitor Baricitinib to treat new-onset Type 1 diabetes Prof Helen Thomas Medicine
Validation of 4D Flow with Exercise using CMR Doctor Ben Costello Baker Department of Cardiometabolic Health
Vascular Health Project Leader Professor Philippe Lehert Medicine
What are antigens/epitopes are recognized in by islet-infiltrating CD8+ T cells in people with type 1 diabetes? A/Prof Stuart Mannering Medicine

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