Cardiometabolic

The School has a varied and strong research history into cardiometabolic diseases, covering conditions including diabetes, obesity, heart disease and different cardiac pathologies.  We conduct cutting-edge research, translating into practical outcomes through our strong links and embedding within leading hospitals in Melbourne, with many of our leading researchers also being clinical practitioners allowing them to directly apply their research in their clinical practice.

Groups / Projects Research Lead Dept / Centre
A monoclonal antibody (mAb1F5) has been developed that identifies the expression of a putative growth factor Dr Peter Wookey Medicine and Radiology
Activated platelets targeted drug therapy Dr Xiaowei Wang Baker Department of Cardiometabolic Health
Additional Signals Project Lead Professor David O'Neal Medicine and Radiology
Adipocyte Biology, Insulin Resistance and Cardiovascular Disease Group Leader Associate Professor Andrew Wilson Medicine and Radiology
Adult Hybrid Closed Loop Study Project Lead Professor David O'Neal Medicine and Radiology
An anti-calcitonin receptor (CTR) antibody for the detection of programmed cell death: the role of CTR in a novel adaptive response in a pre-apoptotic mechanism Dr Peter Wookey Medicine and Radiology
An antibody that detects a high molecular weight surrogate ligand of calcitonin receptor is detected in malignant glioma cells and cell lines Dr Peter J Wookey Medicine and Radiology
An assessment and Validation of screening tools for Sleep Apnea in Singleton and Multiple Pregnancy Dr Megan Rees Medicine and Radiology
Application of computational biology approaches to identify and develop biomarkers to predict pregnancy disorders and guide clinical practice. Professor Eva Dimitriadis Obstetrics and Gynaecology
Arterial grafting for coronary artery revascularisation Co-director Colin Royse
Surgery
Artificial intelligence system to detect eye and cardiovascular diseases Professor Mingguang He Surgery
Atherothrombosis and Vascular Biology Group Head of Laboratory Professor Karlheinz Peter Peter
 Baker Department of Cardiometabolic Health
Biomarkers of Atherosclerosis Group Leader Associate Professor Andrew Wilson Medicine and Radiology
Biomedical Translational Research Group: Developing Therapies for Cardiovascular Disease Group Leader Professor Darren Kelly
Medicine and Radiology
Cardiac Hypertrophy Group Head of Laboratory Associate Professor Julie McMullen
Baker Department of Cardiometabolic Health
Cardiothoracic Surgery Professor Alistair Royse
Surgery
Cardiovascular and Tumourivascular Laboratory Dr Peter J Wookey
Professor David Hare 		Medicine and Radiology
Characterising a New Target to Treat Fatty Liver Disease A/Professor Anna Calkin Baker Department of Cardiometabolic Health
Characterization of GPR35 in models of cardiac and renal disease Dr Andrew Kompa Medicine and Radiology
Chronic Kidney Disease in the Management of people with Type 2 Diabetes in General Practice Project Leader Dr Jo-Anne Manski-Nankervis General Practice
Closed-loop bioelectrical neuromodulation control over bladder function Dr Sophie Payne Medical Bionics Department
Closing the Gap on Aboriginal Cardiovascular Health disparities- Using Big Data to understand the patient health journey Associate Professor Luke Burchill Medicine and Radiology
Cognitive Health Project Leader Professor Cassandra Szoeke Medicine and Radiology
Common severe childhood infections, innate inflammatory responses and cardiometabolic risk: The VASCular changes aFter INfectious Diseases (VASCFIND) study Prof David Burgner Paediatrics
Detecting the tissue of origin of circulating cell free DNA Professor Lachlan Coin Clinical Pathology
Developing novel therapies for the treatment of retinal disease Professor Darren Kelly
Project Lead Dr Amanda Edgley 		Medicine and Radiology
Development of novel therapeutics to prevent or treat preeclampsia Associate Professor Natalie Hannan
Obstetrics and Gynaecology
Diabetes and Cardio-Metabolic Conditions Research Program Leader Associate Professor John Furler
General Practice
Diabetes and Obesity Associate Professor Elif Ekinci
 Medicine and Radiology
Diabetes Discovery - prevalence and outcomes in inpatients with diabetes Project Leader Dr Elif Ekinci Medicine and Radiology
Diabetes Technology Research Group Group Leader Professor David O'Neal
Medicine and Radiology
Diabetic Retinopathy and Health Informatics Collaboratory Group Leader Dr Laima Brazionis
Medicine and Radiology
Diagnosis and therapy of inflammatory diseases using molecular ultrasound imaging Dr Xiaowei Wang Baker Department of Cardiometabolic Health
Drug development for metabolic diseases A/Prof Jon Oakhill Medicine and Radiology
Effect of uraemic toxins of vascular reactivity Dr Andrew Kompa Medicine and Radiology
Elucidating the functional roles of CCL17 in obesity-associated osteoarthritis Dr Adrian Achuthan Medicine and Radiology
Emerging Infectious Diseases and Travel Medicine Research Group Leader Dr Irani Thevarajan
Infectious Diseases
Engineering a tissue flap Dr Geraldine Mitchell Surgery
Evaluation of cardio-metabolic effects of Incretin-based therapies in type 2 diabetes Project Lead Professor Sanjoy Paul Medicine and Radiology
Evaluation of the obesity paradox in diabetes: A longitudinal case-control study of half a million patients Project Lead Professor Sanjoy Paul Medicine and Radiology
Exploring the causes of obesity development and obesity resistance Dr Barbara Fam Medicine and Radiology
Factors that determine islet antigen-specific T cell expansion before the onset of Type 1 diabetes Prof Helen Thomas Medicine and Radiology
Field tests for evaluation and prognostication in interstitial lung disease Dr Yet Hong Khor Medicine and Radiology
Future Health Today - health informatics Associate Professor Jo-Anne Manski-Nankervis General Practice
Future Health Today Changing the course of cardiovascular disease Associate Professor Jo-Anne Manski-Nankervis General Practice
Gene signatures of the ‘lymphaticome’ Dr Ramin Shayan
Dr Tara Karnezis 		Surgery
Haematopoesis and Leukocyte Biology Group Head of Laboratory Associate Professor Andrew Murphy
Baker Department of Cardiometabolic Health
Heart Health in Women: Role of Physical Activity to Prevent Cardiovascular Disease Dr Erin Howden Baker Department of Cardiometabolic Health
How does ageing affect the heart's response to heart attack? A/Professor Anna Calkin Baker Department of Cardiometabolic Health
Hypoglycaemia and its consequences Project Lead Professor Sanjoy Paul Medicine and Radiology
Imaging Project Leader Monique Stagnitti Medicine and Radiology
Immunity, Chronic Inflammation and Cardiovascular Disease Professor Karlheinz Peter Baker Department of Cardiometabolic Health
Inhibiting hypoxia and inflammation-induced damage to improve the outcomes of islet transplantation Dr Michaela Waibel Medicine and Radiology
Inhibition of microglia inflammation by AMPK for obesity treatment Dr Sandra Galic Medicine and Radiology
Investigating a novel mechanism for improving beta-cell function in type 2 diabetes Dr Kim Loh Medicine and Radiology
Investigating cardiovascular disease in Friedreich's ataxia using human induced pluripotent stem cells Dr Shiang (Max) Lim Surgery
Investigating the involvement of novel genes and pathways in islet beta-cell dysfunction and progression to Type 2 Diabetes A/Professor Sof Andrikopoulos Medicine and Radiology
Investigating the role of OIP5-AS1 in cardiovascular diseases A/Professor Brian Drew Baker Department of Cardiometabolic Health
Islet Biology & Metabolism Group A/Professor Sof Andrikopoulos
 Medicine and Radiology
Lifestyle and Prevention Project Leader Dr Edward Hill Medicine and Radiology
Lifestyle Factors and Cognitive Health Professor Cassandra Szoeke Medicine and Radiology
Lipid Metabolism and Cardiometabolic Disease Group Head of Laboratory Associate Professor Anna Calkin
Baker Department of Cardiometabolic Health
Lipoproteins and Cardiovascular Risk from Mid- to Late-life in Women Senior Research Fellow Alexandra Gorelik Medicine and Radiology
Management of acute decompensated heart failure in inpatients with diabetes Project Leader Dr Elif Ekinci Medicine and Radiology
Mechanotransduction in blood cells and consequences for thrombosis and inflammation Professor Karlheinz Peter Baker Department of Cardiometabolic Health
Mental Health Project Leader Professor Lorraine Dennerstein Medicine and Radiology
Metabolomics Group Head of Laboratory Professor Peter Meikle
Baker Department of Cardiometabolic Health
Modelling cardiovascular diseases using human cardiac organoids Doctor Shiang Lim Surgery
Molecular Imaging and Theranostics Group Head of Laboratory Dr Xiaowei Wang
Baker Department of Cardiometabolic Health
Molecular Metabolism and Ageing Group Head of Laboratory Associate Professor Brian Drew
Baker Department of Cardiometabolic Health
Multimorbidity in Ageing Project Leader Dr Kate Gregorevic Medicine and Radiology
Multimorbidity and glycaemia in people with type 2 diabetes attending Australian general practice: a cross-sectional study utilising data from NPS MedicineInsight Principal Investigator A/Prof Jo-Anne Manski-Nankervis General Practice
Musculoskeletal and Bone Health Project Leader Dr Raquel Pedrero-Chamizo Medicine and Radiology
New reagent for detection of program cell death Dr Peter J Wookey Medicine and Radiology
Non-alcoholic fatty liver disease – characterising disease features in order to develop new therapies Dr Amanda Edgley Medicine and Radiology
Novel therapies for the treatment of cardiorenal disease Project Lead Dr Andrew Kompa Medicine and Radiology
Novel therapies for the treatment of cardiorenal syndrome Dr Andrew Kompa Medicine and Radiology
Novel therapies for the treatment of cardiovascular disease Professor Darren Kelly
Project Lead Dr Amanda Edgley 		Medicine and Radiology
Obesity Dr Priya Sumithran
 Medicine and Radiology
Pathophysiology of glycaemic and cardiovascular risk factors in diabetes Project Lead Professor Sanjoy Paul Medicine and Radiology
Point of Care Ultrasound Simulation Education Dr David Canty Surgery
POPS (proactive care of older people undergoing surgery) Prof Kwang Lim Medicine and Radiology
Quality of Life Project Leader Dr Katherine Campbell Medicine and Radiology
Refining the comprehensive geriatric assessment Prof. Andrea Maier Medicine and Radiology
Regulation of ghrelin signalling by AMPK Dr Sandra Galic Medicine and Radiology
Simplifying clinical acid-base diagnosis in critical care Professor David Story Medicine and Radiology
Singing for breathing in people with severe non-malignant, chronic lung diseases Assoc Prof Natasha Smallwood Medicine and Radiology
Spermtyping – Single cell analysis of the generation of genetic diversity via DNA repair pathways Dr Wayne Crismani Medicine and Radiology
Sympathetic activation in adults with inadequate sleep Dr Stephanie Yiallourou Baker Department of Cardiometabolic Health
Targeting inflammation and fibrosis for the treatment of retinal disease Dr Roy Kong Medicine and Radiology
The cardiometabolic legacy of SARS-CoV-2 in longitudinal adolescents Prof David Burgner Paediatrics
The cellular fuel gauge: Novel mechanisms of metabolic control A/Prof Jon Oakhill Medicine and Radiology
The development of anti-NPY1 receptor antibodies for research into and treatment of cardiovascular diseases and cancer Dr Peter J Wookey Medicine and Radiology
The GP-OSMOTIC trial: Continuous Glucose Monitoring in Type 2 Diabetes Project Leader Associate Professor John Furler General Practice
The role of AMP-activated kinase in suppressing atherosclerosis Dr Kim Loh Medicine and Radiology
The treatment of the brain tumour glioblastoma (GBM) Dr Peter J Wookey Medicine and Radiology
Trans Health Research Dr Ada Cheung
 Medicine and Radiology
Translational Cardiovascular Biology Group Leader Associate Professor Andrew Wilson
Medicine and Radiology
Transoesophageal echoardiography in cardiac surgery Co-director Colin Royse
Surgery
Treating fibrosis and inflammation to prevent end-organ damage in diabetes Dr Roy Kong Medicine and Radiology
Treatment outcome in older lung cancer patients: does the biological age predict it? Prof. Andrea Maier Medicine and Radiology
Type I interferon as a novel endogenous trigger of trained immunity Dr Andrew Fleetwood Baker Department of Cardiometabolic Health
Type I interferon as a novel endogenous trigger of trained immunity Dr Andrew Fleetwood Baker Department of Cardiometabolic Health
Ultrasound Education Group Co-director Professor Colin Royse
Co-director Professor Alistair Royse 		Surgery
Understanding antibiotic prescribing and use of guidelines in general practice – the GP National Antimicrobial Prescribing Survey (GP NAPS) pilot study Principal Investigator Dr Jo-Anne Manski-Nankervis General Practice
Understanding how Type 17 immunity and IL-17 cytokines regulate Type 1 diabetes Dr Andrew Sutherland Medicine and Radiology
Use of tools to detect medication related problems in emergency departments Professor Elizabeth Manias Psychiatry
Using the JAK1/JAK2 Inhibitor Baricitinib to treat new-onset Type 1 diabetes Prof Helen Thomas Medicine and Radiology
Vascular Health Project Leader Professor Philippe Lehert Medicine and Radiology
What are antigens/epitopes are recognized in by islet-infiltrating CD8+ T cells in people with type 1 diabetes? A/Prof Stuart Mannering Medicine and Radiology
You are what you eat? The gut microbiome and its regulation of heart disease Dr Yung-Chih Chen Baker Department of Cardiometabolic Health

111