Cardiometabolic

The School has a varied and strong research history into cardiometabolic diseases, covering conditions including diabetes, obesity, heart disease and different cardiac pathologies.  We conduct cutting-edge research, translating into practical outcomes through our strong links and embedding within leading hospitals in Melbourne, with many of our leading researchers also being clinical practitioners allowing them to directly apply their research in their clinical practice.

Groups / Projects Research Lead Dept / Centre
A randomised controlled trial of anti-androgen treatment for transgender women. Prof Jeffrey Zajac Medicine and Radiology
A randomised controlled trial of transdermal versus intramuscular testosterone therapy in transgender males Prof Jeffrey Zajac Medicine and Radiology
Adipocyte Biology, Insulin Resistance and Cardiovascular Disease Group Leader Associate Professor Andrew Wilson Medicine and Radiology
AMPK regulation of cholesterol metabolism Prof Bruce Kemp Medicine and Radiology
AMPK regulation of lipid metabolism Prof Bruce Kemp Medicine and Radiology
An anti-calcitonin receptor (CTR) antibody for the detection of programmed cell death: the role of CTR in a novel adaptive response in a pre-apoptotic mechanism Dr Peter Wookey Medicine and Radiology
Analysing the mutations in calcitonin receptor (CTR) mRNA transcripts, and identifying the isoforms and polymorphisms of CTR expressed in high grade glioma cell lines from glioblastoma Dr Peter Wookey Medicine and Radiology
Arterial coronary artery bypass surgery Prof Alistair Royse
Prof Colin Royse
Surgery
Arterial grafting for coronary artery revascularisation Co-director Colin Royse
Surgery
Assessment of mitochondrial function in a mouse model of obesity and type 2 diabetes A/Prof Sof Andrikopoulos Medicine and Radiology
Biomarkers of Atherosclerosis Group Leader Associate Professor Andrew Wilson Medicine and Radiology
Biomedical Translational Research Group: Developing Therapies for Cardiovascular Disease Group Leader Professor Darren Kelly
Medicine and Radiology
Can preoperative focused cardiac ultrasound improve morbidity and mortality after emergency noncardiac surgery? a pilot RCT A/Prof David Canty
Prof Colin Royse
Surgery
Cardioprotection with Nano-MDIVI-1 Dr Shiang (Max) Lim Surgery
Cardiovascular and Tumourivascular Laboratory Group Leader Dr Peter J Wookey
Medicine and Radiology
Cardiovascular Risk in Nephrotic Syndrome Dr Jonathan Mynard
Dr Catherine Quinlan
Paediatrics
Characterisation of GLUT12 knockout mice Prof Bruce Kemp Medicine and Radiology
Characterization of GPR35 in models of cardiac and renal disease Dr Andrew Kompa
Dr Amanda Edgley
Medicine and Radiology
Chronic Kidney Disease in the Management of people with Type 2 Diabetes in General Practice Project Leader Dr Jo-Anne Manski-Nankervis General Practice
Cognitive Health Group Leader Professor Cassandra Szoeke Medicine and Radiology
Comparison of learning focused cardiac ultrasound between self-directed and proctored simulator teaching pf medical students A/Prof David Canty
Prof Colin Royse
Surgery
Connecting a macro-vessel to a pre-vascularized scaffold A/Prof Geraldine Mitchell Surgery
Creating transplantable human capillary networks derived from adult human stem cells A/Prof Geraldine Mitchell Surgery
Developing novel therapies for the treatment of retinal disease Professor Darren Kelly
Project Lead Dr Amanda Edgley
Medicine and Radiology
Diabetes and Cardio-Metabolic Conditions Research Program Leader Associate Professor John Furler
General Practice
Diabetes and Obesity Associate Professor Elif Ekinci
Professor Joe Proietto
Medicine and Radiology
Diabetes Discovery - prevalence and outcomes in inpatients with diabetes Project Leader Dr Elif Ekinci Medicine and Radiology
Diabetic Retinopathy and Health Informatics Collaboratory Group Leader Dr Laima Brazionis
Medicine and Radiology
Effect of uraemic toxins of vascular reactivity Dr Andrew Kompa Medicine and Radiology
Effects of Dichloroacetic Acid (DCA) on Exercise Performance in Patients with Heart Failure with Preserved Ejection Fraction (HFpEF): a Randomized, Placebo-Controlled, Cross-Over Trial AssociateProfessor Chris Neil Medicine and Radiology
Evaluation of cardio-metabolic effects of Incretin-based therapies in type 2 diabetes Project Lead Professor Sanjoy Paul Medicine and Radiology
Evaluation of the obesity paradox in diabetes: A longitudinal case-control study of half a million patients Project Lead Professor Sanjoy Paul Medicine and Radiology
Exploring the microbiome and epigenetic links in obesity development Dr Barbara Fam Medicine and Radiology
Gene signatures of the ‘lymphaticome’ Dr Ramin Shayan
Dr Tara Karnezis
Surgery
Genetic Analysis of Impaired beta Cell Function and Loss in Type 2 diabetes A/Prof Sof Andrikopoulos Medicine and Radiology
Goal-directed cognitive rehabilitation for self-management in older diabetic adults Dr Alex Bahar-Fuchs Medicine and Radiology
High Dose Vitamin D and Post-Stroke Outcomes: A Randomized Controlled Trial Associate Professor Tissa Wijeratne Medicine and Radiology
How do HLA-DQ2 and DQ-8 increase the risk of people developing Type 1 diabetes? A/Prof Stuart Mannering Medicine and Radiology
How do long noncoding RNAs (IncRNAs) regulate dendritic cell function and prevent autoimmune disease? Dr Tom Brodnicki Medicine and Radiology
How does amino acid supply immune cell function and the development of autoimmune disease? Dr Tom Brodnicki Medicine and Radiology
Hypoglycaemia and its consequences Project Lead Professor Sanjoy Paul Medicine and Radiology
Identifying IL-17 receptor functions in pancreatic beta cells A/Prof Helen Thomas Medicine and Radiology
Imaging Group Leader Professor Cassandra Szoeke Medicine and Radiology
Inhibiting hypoxia and inflammation-induced damage to improve the outcomes of islet transplantation A/Prof Helen Thomas Medicine and Radiology
Investigating the effects of GM-CSF and M-CSF derived human macrophages on phagocytosing P. falciparum infected erythrocytes and cytokine production Dr Adrian Achuthan Medicine and Radiology
Investigation of inter-arm blood pressure differences during paediatric exercise testing Dr Jonathan Mynard
Dr Michael Cheung
Paediatrics
Lifestyle and Prevention Group Leader Professor Cassandra Szoeke Medicine and Radiology
Management of acute decompensated heart failure in inpatients with diabetes Project Leader Dr Elif Ekinci Medicine and Radiology
Mental Health Group Leader Professor Cassandra Szoeke Medicine and Radiology
Modulating fibrosis and myocardial injury in Muscular Dystrophy Dr Adam Piers
A/Professor Salvatore Pepe
Paediatrics
Modulation of CAMKK-Beta signalling by genetic variants Prof Bruce Kemp Medicine and Radiology
Molecular mediators of gene:environment interactions underlying early life programming of cardiovascular and metabolic risk. Professor Richard Saffery
Dr David Burgner
Paediatrics
Multimorbidity in Ageing Group Leader Professor Cassandra Szoeke Medicine and Radiology
Multimorbidity and glycaemia in people with type 2 diabetes attending Australian general practice: a cross-sectional study utilising data from NPS MedicineInsight Principal Investigator Dr Jo-Anne Manski-Nankervis General Practice
Musculoskeletal and Bone Health Group Leader Professor Cassandra Szoeke Medicine and Radiology
New inhibitors for mitochondrial fission protein DRP1 Dr Jessica Holien
Dr Shiang (Max) Lim
Surgery
Non-alcoholic fatty liver disease – characterising disease features in order to develop new therapies Dr Amanda Edgley Medicine and Radiology
Novel therapies for the treatment of cardiorenal disease Project Lead Dr Andrew Kompa Medicine and Radiology
Novel therapies for the treatment of cardiorenal syndrome Dr Andrew Kompa Medicine and Radiology
Novel therapies for the treatment of cardiovascular disease Professor Darren Kelly
Project Lead Dr Amanda Edgley
Medicine and Radiology
Pathophysiology of glycaemic and cardiovascular risk factors in diabetes Project Lead Professor Sanjoy Paul Medicine and Radiology
Peak exercise capacity in patients with a Fontan circulation Professor Yves D'Udekem
Dr Rachael Cordina
Paediatrics
Post-translational regulation of AMPK Prof Bruce Kemp Medicine and Radiology
Quality of Life Group Leader Professor Cassandra Szoeke Medicine and Radiology
Quantitating Corneal Density in Fabry Disease A/Prof Kathy Nicholls Medicine and Radiology
Refining the comprehensive geriatric assessment Prof. Kwang Lim Medicine and Radiology
Repurposing JAK1/JAK2 inhibitors to treat Type 1 diabetes Prof Tom Kay Medicine and Radiology
Serial Evaluation of Cardiac and Vascular Function in Preeclampsia: Full Recovery or Persistent LV Contractile Impairment? Professor Joanne Said Medicine and Radiology
Significance and Temporal Course of Advanced Echocardiographic Measurements of Left Ventricular Function in an Australian Cohort of Stage A Heart Failure, with High Baseline Cardiovascular Risk A/Professor Chris Neil Medicine and Radiology
Small vessel disease as a marker for poorly controlled hypertension Prof Judy Savige Medicine and Radiology
Spermtyping – Single cell analysis of the generation of genetic diversity via DNA repair pathways Dr Wayne Crismani Medicine and Radiology
Targeting inflammation and fibrosis for the treatment of retinal disease Dr Roy Kong Medicine and Radiology
The blood pressure drop makes you fall Dr. Julian Sacre Medicine and Radiology
The economic impact of total arterial grafting in coronary arterial bypass graft surgery compared to arterial and venous grafting A/Prof David Canty
Prof Andrew Palmer
Surgery
The GP-OSMOTIC trial: Continuous Glucose Monitoring in Type 2 Diabetes Project Leader Associate Professor John Furler General Practice
The intra-individual rate of ageing Prof. Andrea Maier Medicine and Radiology
The radial artery in coronary bypass surgery Prof Alistair Royse
Prof Colin Royse
Surgery
The role of an isoform of calcitonin receptor in glioma stem cells Dr Peter Wookey Medicine and Radiology
The role of nucleic acid sensing in triggering autoimmune diabetes Dr Tom Brodnicki Medicine and Radiology
Therapeutic Inertia for Glycaemic and Cardiovascular Risk Factor Control in Patients with Type 2 Diabetes: A Real-world Electronic Medical Records Based Study Professor Sanjoy Paul Medicine and Radiology
Towards a biological geriatric assessment Dr. Camilla Tuttle Medicine and Radiology
Translational Cardiovascular Biology Group Leader Associate Professor Andrew Wilson
Medicine and Radiology
Transoesophageal echoardiography in cardiac surgery Co-director Colin Royse
Surgery
Treating fibrosis and inflammation to prevent end-organ damage in diabetes Dr Roy Kong Medicine and Radiology
Ultrasound Education Group Co-director Professor Colin Royse
Professor Alistair Royse
Surgery
Understanding antibiotic prescribing and use of guidelines in general practice – the GP National Antimicrobial Prescribing Survey (GP NAPS) pilot study Principal Investigator Dr Jo-Anne Manski-Nankervis General Practice
Understanding how interferons are involved in autoimmune diabetes Dr Tom Brodnicki Medicine and Radiology
Understanding if islet-infiltrating CTL can be identified in peripheral blood as biomarkers of Type 1 diabetes Dr Bala Krishnamurthy Medicine and Radiology
Validation and Reliability of a Japanese ver. of PostopQRS Prof Colin Royse
Surgery
Vascular Health Group Leader Professor Cassandra Szoeke Medicine and Radiology
Women's Healthy Ageing Project Group Leader Professor Cassandra Szoeke Medicine and Radiology

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