Cardiometabolic

The School has a varied and strong research history into cardiometabolic diseases, covering conditions including diabetes, obesity, heart disease and different cardiac pathologies. We conduct cutting-edge research, translating into practical outcomes through our strong links and embedding within leading hospitals in Melbourne, with many of our leading researchers also being clinical practitioners allowing them to directly apply their research in their clinical practice.

Groups / Projects	Research Lead	Dept / Centre
: Unravelling the role of breast milk ether lipids in modulating immune function in early life	Professor Peter Meikle	Baker Department of Cardiometabolic Health
A monoclonal antibody (mAb1F5) has been developed that identifies a unique marker, a membrane protein expressed by pericytes and meningeal cells	Dr Peter Wookey	Medicine
A New reagent for detection of program cell death	Dr Peter J Wookey	Medicine
A novel approach in improving lipidomics throughput for population profiling	Professor Peter Meikle	Baker Department of Cardiometabolic Health
Activated platelets targeted drug therapy	Dr Xiaowei Wang	Baker Department of Cardiometabolic Health
Additional Signals	Project Lead Professor David O'Neal	Medicine
Adipocyte Biology, Insulin Resistance and Cardiovascular Disease	Group Leader Associate Professor Andrew Wilson	Medicine
Adult Hybrid Closed Loop Study	Project Lead Professor David O'Neal	Medicine
An anti-calcitonin receptor (CTR) antibody for detection of programmed cell death: the role of CTR in a novel adaptive response to cell stress	Dr Peter Wookey	Medicine
An antibody (mAb2E1) that detects a novel, high molecular weight surrogate ligand of calcitonin receptor is detected in malignant glioma cells, developing brain and bone, and an osteosarcoma cell line	Dr Peter J Wookey	Medicine
An antibody that detects a high molecular weight surrogate ligand of calcitonin receptor is detected in malignant glioma cells and cell lines.	Dr Peter J Wookey	Medicine
Application of computational biology approaches to identify and develop biomarkers to predict pregnancy disorders and guide clinical practice.	Professor Eva Dimitriadis	Obstetrics and Gynaecology
Arterial grafting for coronary artery revascularisation	Co-director Colin Royse	Surgery
Artificial intelligence system to detect eye and cardiovascular diseases	Professor Mingguang He	Surgery
Assessing the therapeutic effects of plasmalogen supplementation in a mouse model of heart failure	Dr Yow Keat Tham	Baker Department of Cardiometabolic Health
Atherothrombosis and Vascular Biology Group	Head of Laboratory Professor Karlheinz Peter Peter	Baker Department of Cardiometabolic Health
Baker Department of Cardiometabolic Health Research		Baker Department of Cardiometabolic Health
Biomarkers of Atherosclerosis	Group Leader Associate Professor Andrew Wilson	Medicine
Biomedical Translational Research Group: Developing Therapies for Cardiovascular Disease	Group Leader Professor Darren Kelly	Medicine
Brain storming therapeutics for neurodegeneration with novel research models	A/Prof Brian Drew	Baker Department of Cardiometabolic Health
Cardiac Cellular Systems	Laboratory Head Dr Alexander Pinto	Baker Department of Cardiometabolic Health Research
Cardiac Hypertrophy Group	Head of Laboratory Professor Julie McMullen	Baker Department of Cardiometabolic Health
Cardiothoracic Surgery	Professor Alistair Royse	Surgery
Cardiovascular and Tumourivascular Laboratory	Dr Peter J Wookey Professor David Hare	Medicine
Cardiovascular Inflammation and Redox Biology	Head of Laboratory Professor Judy de Haan	Baker Department of Cardiometabolic Health Research
Cellular and Molecular Mechanisms Driving Anthracycline-Induced Cardiotoxicity in Children	Dr Alexander Pinto	Baker Department of Cardiometabolic Health
Cellular and Molecular Mechanisms Driving Anthracycline-Induced Cardiotoxicity in Children	Dr Alexander Pinto	Baker Department of Cardiometabolic Health
Chronic Kidney Disease in the Management of people with Type 2 Diabetes in General Practice	Project Leader Dr Jo-Anne Manski-Nankervis	General Practice
Clinical Diabetes and Epidemiology Group	Deputy Director (Clinical and Population Health), Baker Institute Professor Jonathan Shaw	Baker Department of Cardiometabolic Health Research
Cognitive Health	Project Leader Professor Cassandra Szoeke	Medicine
Common severe childhood infections, innate inflammatory responses and cardiometabolic risk: The VASCular changes aFter INfectious Diseases (VASCFIND) study	Prof David Burgner	Paediatrics
Detecting the tissue of origin of circulating cell free DNA	Professor Lachlan Coin	Clinical Pathology
Developing nanoparticles for targeted theranostics delivery of drug and gene therapeutics	Dr Xiaowei Wang	Baker Department of Cardiometabolic Health
Developing platelet derived nanoparticles for targeted thrombolysis	Prof Karlheinz Peter	Baker Department of Cardiometabolic Health
Development and validation of a high throughput clinical lipidomics platform	Professor Peter Meikle	Baker Department of Cardiometabolic Health
Development of novel therapeutics to prevent or treat preeclampsia	Associate Professor Natalie Hannan	Obstetrics and Gynaecology
Diabetes and Cardio-Metabolic Conditions	Research Program Leader Professor John Furler	General Practice
Diabetes and Obesity	Associate Professor Elif Ekinci	Medicine
Diabetes Discovery - prevalence and outcomes in inpatients with diabetes	Project Leader Dr Elif Ekinci	Medicine
Diabetes Technology Research Group	Group Leader Professor David O'Neal	Medicine
Diabetic Retinopathy Research Group	Group Leader Dr Laima Brazionis	Medicine
Diagnosis and therapy of inflammatory diseases using molecular ultrasound imaging	Dr Xiaowei Wang	Baker Department of Cardiometabolic Health
Digital Health	Group Leader Chris Ryan	Medicine
Do short chain fatty acids prevent gut leakiness and enhanced haematopoiesis induced by a high salt diet?	Prof Andrew Murphy	Baker Department of Cardiometabolic Health
Does epicardial adipose tissue contribute to atrial fibrillation in endurance athletes?	Dr Erin Howden	Baker Department of Cardiometabolic Health
Drug development for metabolic diseases	A/Prof Jon Oakhill	Medicine
Dyslipidemia Decision Support		Medicine
Emerging Infectious Diseases and Travel Medicine	Research Group Leader Dr Irani Thevarajan	Infectious Diseases
Engineering a tissue flap	Dr Geraldine Mitchell	Surgery
Exploring how a high salt diet promotes bone destruction through immune cell activation	Prof Andrew Murphy	Baker Department of Cardiometabolic Health
Exploring how diabetes causes increased proliferation of haematopoietic stem cells carrying a mutation in DNMT3A	Prof Andrew Murphy	Baker Department of Cardiometabolic Health
Exploring the contribution of intrinsic lipids to immune cell development and function	Professor Andrew Murphy	Baker Department of Cardiometabolic Health
Exploring the therapeutic potential of protein phosphatases in cardiometabolic disease	Dr Kate Weeks	Baker Department of Cardiometabolic Health
Factors that determine islet antigen-specific T cell expansion before the onset of Type 1 diabetes	Prof Helen Thomas	Medicine
Future Health Today Changing the course of cardiovascular disease	Associate Professor Jo-Anne Manski-Nankervis	General Practice
Gene signatures of the ‘lymphaticome’	Dr Ramin Shayan Dr Tara Karnezis	Surgery
Genomics of asthma mortality due to thunderstorm asthma	Prof Jo Douglass	Medicine
Haematopoesis and Leukocyte Biology Group	Head of Laboratory Associate Professor Andrew Murphy	Baker Department of Cardiometabolic Health
Heart Health in Women: Role of Physical Activity to Prevent Cardiovascular Disease	Dr Erin Howden	Baker Department of Cardiometabolic Health
Human Integrative Physiology	Head of Laboratory Dr Erin Howden	Baker Department of Cardiometabolic Health
Identification of additional markers of ferroptosis with mass spectrometry	Professor Peter Meikle	Baker Department of Cardiometabolic Health
Identifying circadian clock and mineralocorticoid receptor (MR) interactions in heart disease	Associate Professor Morag Young	Baker Department of Cardiometabolic Health
Imaging	Project Leader Monique Stagnitti	Medicine
Immunity, Chronic Inflammation and Cardiovascular Disease	Professor Karlheinz Peter	Baker Department of Cardiometabolic Health
Inhibition of microglia inflammation by AMPK for obesity treatment	Dr Sandra Galic	Medicine
Integration of population level ‘omics data to target cardiometabolic disease	Professor Peter Meikle	Baker Department of Cardiometabolic Health
Investigating a novel mechanism for improving beta-cell function in type 2 diabetes	Dr Kim Loh	Medicine
Investigating cardiovascular disease in Friedreich's ataxia using human induced pluripotent stem cells	Dr Shiang (Max) Lim	Surgery
Irani Thevarajan	Dr Irani Thevarajan	Infectious Diseases
Islet Biology & Metabolism Group	A/Professor Sof Andrikopoulos	Medicine
Lifestyle and Prevention	Project Leader Dr Edward Hill	Medicine
Lifestyle Factors and Cognitive Health	Professor Cassandra Szoeke	Medicine
Lipid Metabolism and Cardiometabolic Disease Group	Head of Laboratory Associate Professor Anna Calkin	Baker Department of Cardiometabolic Health
Lipidomic Profiling of Atrial Fibrillation Progression in a Murine Model	Dr Yow Keat Tham	Baker Department of Cardiometabolic Health
Lipoproteins and Cardiovascular Risk from Mid- to Late-life in Women	Senior Research Fellow Alexandra Gorelik	Medicine
Management of acute decompensated heart failure in inpatients with diabetes	Project Leader Dr Elif Ekinci	Medicine
Mechanotransduction in blood cells and consequences for thrombosis and inflammation	Professor Karlheinz Peter	Baker Department of Cardiometabolic Health
Mental Health	Project Leader Professor Lorraine Dennerstein	Medicine
Metabolomics Group	Head of Laboratory Professor Peter Meikle	Baker Department of Cardiometabolic Health
Mineralocorticoid receptor activation pathways in macrophages ; new mechanisms of heart failure	Associate Professor Morag Young	Baker Department of Cardiometabolic Health
Modelling cardiovascular diseases using human cardiac organoids	Doctor Shiang Lim	Surgery
Molecular Imaging and Theranostics Group	Head of Laboratory Dr Xiaowei Wang	Baker Department of Cardiometabolic Health
Molecular Metabolism and Ageing Group	Head of Laboratory Associate Professor Brian Drew	Baker Department of Cardiometabolic Health
Multimorbidity in Ageing	Project Leader Dr Kate Gregorevic	Medicine
Multimorbidity and glycaemia in people with type 2 diabetes attending Australian general practice: a cross-sectional study utilising data from NPS MedicineInsight	Principal Investigator A/Prof Jo-Anne Manski-Nankervis	General Practice
Musculoskeletal and Bone Health	Project Leader Dr Raquel Pedrero-Chamizo	Medicine
Non-alcoholic fatty liver disease – characterising disease features in order to develop new therapies	Dr Amanda Edgley	Medicine
Novel regenerative therapies in cardiovascular diseases	Prof Karlheinz Peter	Baker Department of Cardiometabolic Health
Novel therapies for atherosclerotic plaque stabilization	Prof Karlheinz Peter	Baker Department of Cardiometabolic Health
Novel therapies for the treatment of cardiorenal disease	Project Lead Dr Andrew Kompa	Medicine
Novel therapies for the treatment of cardiorenal syndrome	Dr Andrew Kompa	Medicine
Novel therapies for the treatment of cardiovascular disease	Professor Darren Kelly Project Lead Dr Amanda Edgley	Medicine
Nuclear receptor co-regulators in heart disease and inflammation; new targets for fine-tuning receptor actions in health and disease	Associate Professor Morag Young	Baker Department of Cardiometabolic Health
Obesity	Dr Priya Sumithran	Medicine
Plasmalogen modulation as a therapeutic approach for fatty liver disease	Professor Peter Meikle	Baker Department of Cardiometabolic Health
Point of Care Ultrasound Simulation Education	Dr David Canty	Surgery
Preclinical Disease and Prevention	Head of Laboratory Associate Professor Melinda Carrington	Baker Department of Cardiometabolic Health Research
Quality of Life	Project Leader Dr Katherine Campbell	Medicine
Data interoperability for remote patient monitoring		Medicine
Artificial Intelligence-assisted Retinal Photography		Medicine
Sex and the broken heart: sex-specific mechanisms driving heart failure	Dr Alexander Pinto	Baker Department of Cardiometabolic Health
SMS Diabetes Education		Medicine
Sympathetic activation in adults with inadequate sleep	Dr Stephanie Yiallourou	Baker Department of Cardiometabolic Health
Targeting inflammation and fibrosis for the treatment of retinal disease	Dr Roy Kong	Medicine
Targeting Pyroptosis to improve diabetic cardiovascular disease.	Prof Judy de Haan	Baker Department of Cardiometabolic Health
The cellular fuel gauge: Novel mechanisms of metabolic control	A/Prof Jon Oakhill	Medicine
The characterisation of CT Receptor expression in the CNS and perinatal PNS: the distribution, intracellular associations and functions of isoforms.	Dr Peter J Wookey	Medicine
The development of anti-NPY1 receptor antibodies for research into and treatment of cardiovascular diseases and cancer	Dr Peter J Wookey	Medicine
The development of anti-NPY1 receptor antibodies for research into and treatment of cardiovascular diseases and cancer.	Dr Peter J Wookey	Medicine
The effect of ageing and sex differences on heart recovery following a heart attack	Associate Professor Anna Calkin	Baker Department of Cardiometabolic Health
The GP-OSMOTIC trial: Continuous Glucose Monitoring in Type 2 Diabetes	Project Leader Associate Professor John Furler	General Practice
The role of AMP-activated kinase in suppressing atherosclerosis	Dr Kim Loh	Medicine
The treatment of the brain tumour glioblastoma (GBM): the efficacy of immunotoxin derived from anti-calcitonin receptor antibodies	Dr Peter J Wookey	Medicine
Trans Health Research	Dr Ada Cheung	Medicine
Translational Cardiovascular Biology	Group Leader Associate Professor Andrew Wilson	Medicine
Transoesophageal echoardiography in cardiac surgery	Co-director Colin Royse	Surgery
Treating fibrosis and inflammation to prevent end-organ damage in diabetes	Dr Roy Kong	Medicine
Type I interferon as a novel endogenous trigger of trained immunity	Dr Andrew Fleetwood	Baker Department of Cardiometabolic Health
Ultrasound Education Group	Co-director Professor Colin Royse Co-director Professor Alistair Royse	Surgery
Understanding antibiotic prescribing and use of guidelines in general practice – the GP National Antimicrobial Prescribing Survey (GP NAPS) pilot study	Principal Investigator Dr Jo-Anne Manski-Nankervis	General Practice
Understanding how Type 17 immunity and IL-17 cytokines regulate Type 1 diabetes	Dr Andrew Sutherland	Medicine
Understanding the role of the circadian molecular clock in the development of dilated cardiac myopathy and atrial fibrillation.	Associate Professor Morag Young	Baker Department of Cardiometabolic Health
Understanding the role of the mineralocorticoid receptor in diabetic cardiac myopathy?	Associate Professor Morag Young	Baker Department of Cardiometabolic Health
Unravelling the causes of persistent exercise intolerance in cancer survivors	Dr Steve Foulkes	Baker Department of Cardiometabolic Health
Using the JAK1/JAK2 Inhibitor Baricitinib to treat new-onset Type 1 diabetes	Prof Helen Thomas	Medicine
Validation of 4D Flow with Exercise using CMR	Doctor Ben Costello	Baker Department of Cardiometabolic Health
Vascular Health	Project Leader Professor Philippe Lehert	Medicine
What are antigens/epitopes are recognized in by islet-infiltrating CD8+ T cells in people with type 1 diabetes?	A/Prof Stuart Mannering	Medicine

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