Cardiometabolic

The School has a varied and strong research history into cardiometabolic diseases, covering conditions including diabetes, obesity, heart disease and different cardiac pathologies. We conduct cutting-edge research, translating into practical outcomes through our strong links and embedding within leading hospitals in Melbourne, with many of our leading researchers also being clinical practitioners allowing them to directly apply their research in their clinical practice.

Groups / Projects	Research Lead	Dept / Centre
A monoclonal antibody (mAb1F5) has been developed that identifies the expression of a putative growth factor	Dr Peter Wookey	Medicine and Radiology
Activated platelets targeted drug therapy	Dr Xiaowei Wang	Baker Department of Cardiometabolic Health
Additional Signals	Project Lead Professor David O'Neal	Medicine and Radiology
Adipocyte Biology, Insulin Resistance and Cardiovascular Disease	Group Leader Associate Professor Andrew Wilson	Medicine and Radiology
Adult Hybrid Closed Loop Study	Project Lead Professor David O'Neal	Medicine and Radiology
An anti-calcitonin receptor (CTR) antibody for the detection of programmed cell death: the role of CTR in a novel adaptive response in a pre-apoptotic mechanism	Dr Peter Wookey	Medicine and Radiology
An antibody that detects a high molecular weight surrogate ligand of calcitonin receptor is detected in malignant glioma cells and cell lines	Dr Peter J Wookey	Medicine and Radiology
Arterial grafting for coronary artery revascularisation	Co-director Colin Royse	Surgery
Biomarkers of Atherosclerosis	Group Leader Associate Professor Andrew Wilson	Medicine and Radiology
Biomedical Translational Research Group: Developing Therapies for Cardiovascular Disease	Group Leader Professor Darren Kelly	Medicine and Radiology
Cardiovascular and Tumourivascular Laboratory	Dr Peter J Wookey Professor David Hare	Medicine and Radiology
Characterization of GPR35 in models of cardiac and renal disease	Dr Andrew Kompa	Medicine and Radiology
Chronic Kidney Disease in the Management of people with Type 2 Diabetes in General Practice	Project Leader Dr Jo-Anne Manski-Nankervis	General Practice
Closed-loop bioelectrical neuromodulation control over bladder function	Dr Sophie Payne	Medical Bionics Department
Closing the Gap on Aboriginal Cardiovascular Health disparities- Using Big Data to understand the patient health journey	Associate Professor Luke Burchill	Medicine and Radiology
Cognitive Health	Project Leader Professor Cassandra Szoeke	Medicine and Radiology
Common severe childhood infections, innate inflammatory responses and cardiometabolic risk: The VASCular changes aFter INfectious Diseases (VASCFIND) study	Prof David Burgner	Paediatrics
Detecting the tissue of origin of circulating cell free DNA	Professor Lachlan Coin	Clinical Pathology
Developing novel therapies for the treatment of retinal disease	Professor Darren Kelly Project Lead Dr Amanda Edgley	Medicine and Radiology
Diabetes and Cardio-Metabolic Conditions	Research Program Leader Associate Professor John Furler	General Practice
Diabetes and Obesity	Associate Professor Elif Ekinci	Medicine and Radiology
Diabetes Discovery - prevalence and outcomes in inpatients with diabetes	Project Leader Dr Elif Ekinci	Medicine and Radiology
Diabetes Technology Research Group	Group Leader Professor David O'Neal	Medicine and Radiology
Diabetic Retinopathy and Health Informatics Collaboratory	Group Leader Dr Laima Brazionis	Medicine and Radiology
Diagnosis and therapy of inflammatory diseases using molecular ultrasound imaging	Dr Xiaowei Wang	Baker Department of Cardiometabolic Health
Drug development for metabolic diseases	A/Prof Jon Oakhill
Effect of uraemic toxins of vascular reactivity	Dr Andrew Kompa	Medicine and Radiology
Engineering a tissue flap	Dr Geraldine Mitchell	Surgery
Evaluation of cardio-metabolic effects of Incretin-based therapies in type 2 diabetes	Project Lead Professor Sanjoy Paul	Medicine and Radiology
Evaluation of the obesity paradox in diabetes: A longitudinal case-control study of half a million patients	Project Lead Professor Sanjoy Paul	Medicine and Radiology
Exploring the causes of obesity development and obesity resistance	Dr Barbara Fam	Medicine and Radiology
Factors that determine islet antigen-specific T cell expansion before the onset of Type 1 diabetes	Prof Helen Thomas	Medicine and Radiology
Field tests for evaluation and prognostication in interstitial lung disease	Dr Yet Hong Khor	Medicine and Radiology
Future Health Today - health informatics	Associate Professor Jo-Anne Manski-Nankervis	General Practice
Future Health Today Changing the course of cardiovascular disease	Associate Professor Jo-Anne Manski-Nankervis	General Practice
Gene signatures of the ‘lymphaticome’	Dr Ramin Shayan Dr Tara Karnezis	Surgery
Hypoglycaemia and its consequences	Project Lead Professor Sanjoy Paul	Medicine and Radiology
Imaging	Project Leader Monique Stagnitti	Medicine and Radiology
Immunity, Chronic Inflammation and Cardiovascular Disease	Professor Karlheinz Peter	Baker Department of Cardiometabolic Health
Inhibiting hypoxia and inflammation-induced damage to improve the outcomes of islet transplantation	Dr Michaela Waibel	Medicine and Radiology
Inhibition of microglia inflammation by AMPK for obesity treatment	Dr Sandra Galic	Medicine and Radiology
Investigating a novel mechanism for improving beta-cell function in type 2 diabetes	Dr Kim Loh	Medicine and Radiology
Investigating cardiovascular disease in Friedreich's ataxia using human induced pluripotent stem cells	Dr Shiang (Max) Lim	Surgery
Investigating the involvement of novel genes and pathways in islet beta-cell dysfunction and progression to Type 2 Diabetes	A/Professor Sof Andrikopoulos	Medicine and Radiology
Islet Biology & Metabolism Group	A/Professor Sof Andrikopoulos	Medicine and Radiology
Lifestyle and Prevention	Project Leader Dr Edward Hill	Medicine and Radiology
Lifestyle Factors and Cognitive Health	Professor Cassandra Szoeke	Medicine and Radiology
Lipoproteins and Cardiovascular Risk from Mid- to Late-life in Women	Senior Research Fellow Alexandra Gorelik	Medicine and Radiology
Management of acute decompensated heart failure in inpatients with diabetes	Project Leader Dr Elif Ekinci	Medicine and Radiology
Mechanotransduction in blood cells and consequences for thrombosis and inflammation	Professoe Karlheinz Peter	Baker Department of Cardiometabolic Health
Mental Health	Project Leader Professor Lorraine Dennerstein	Medicine and Radiology
Modelling cardiovascular diseases using human cardiac organoids	Doctor Shiang Lim	Surgery
Multimorbidity in Ageing	Project Leader Dr Kate Gregorevic	Medicine and Radiology
Multimorbidity and glycaemia in people with type 2 diabetes attending Australian general practice: a cross-sectional study utilising data from NPS MedicineInsight	Principal Investigator Dr Jo-Anne Manski-Nankervis	General Practice
Musculoskeletal and Bone Health	Project Leader Dr Raquel Pedrero-Chamizo	Medicine and Radiology
New reagent for detection of program cell death	Dr Peter J Wookey	Medicine and Radiology
Non-alcoholic fatty liver disease – characterising disease features in order to develop new therapies	Dr Amanda Edgley	Medicine and Radiology
Novel therapies for the treatment of cardiorenal disease	Project Lead Dr Andrew Kompa	Medicine and Radiology
Novel therapies for the treatment of cardiorenal syndrome	Dr Andrew Kompa	Medicine and Radiology
Novel therapies for the treatment of cardiovascular disease	Professor Darren Kelly Project Lead Dr Amanda Edgley	Medicine and Radiology
Obesity	Dr Priya Sumithran	Medicine and Radiology
Pathophysiology of glycaemic and cardiovascular risk factors in diabetes	Project Lead Professor Sanjoy Paul	Medicine and Radiology
Point of Care Ultrasound Simulation Education	Dr David Canty	Surgery
Quality of Life	Project Leader Dr Katherine Campbell	Medicine and Radiology
Refining the comprehensive geriatric assessment	Prof. Andrea Maier	Medicine and Radiology
Regulation of ghrelin signalling by AMPK	Dr Sandra Galic	Medicine and Radiology
Simplifying clinical acid-base diagnosis in critical care	Professor David Story	Medicine and Radiology
Sternal ultrasound assessment of plate vs. wire fixation	Prof Alistair Royse	Surgery
Sympathetic activation in adults with inadequate sleep	Stephanie Yiallourou	Baker Department of Cardiometabolic Health
Targeting inflammation and fibrosis for the treatment of retinal disease	Dr Roy Kong	Medicine and Radiology
The blood pressure drop makes you fall	Prof. Andrea Maier	Medicine and Radiology
The cardiometabolic legacy of SARS-CoV-2 in longitudinal adolescents	Prof David Burgner	Paediatrics
The cellular fuel gauge: Novel mechanisms of metabolic control	A/Prof Jon Oakhill	Medicine and Radiology
The development of anti-NPY1 receptor antibodies for research into and treatment of cardiovascular diseases and cancer	Dr Peter J Wookey	Medicine and Radiology
The GP-OSMOTIC trial: Continuous Glucose Monitoring in Type 2 Diabetes	Project Leader Associate Professor John Furler	General Practice
The role of AMP-activated kinase in suppressing atherosclerosis	Dr Kim Loh	Medicine and Radiology
The treatment of the brain tumour glioblastoma (GBM)	Dr Peter J Wookey	Medicine and Radiology
Tracking Physical Activity in Young Adults with Heart Disease	Associate Professor Luke Burchill	Medicine and Radiology
Trans Health Research	Dr Ada Cheung	Medicine and Radiology
Translational Cardiovascular Biology	Group Leader Associate Professor Andrew Wilson	Medicine and Radiology
Transoesophageal echoardiography in cardiac surgery	Co-director Colin Royse	Surgery
Treating fibrosis and inflammation to prevent end-organ damage in diabetes	Dr Roy Kong	Medicine and Radiology
Treatment outcome in older lung cancer patients: does the biological age predict it?	Prof. Andrea Maier	Medicine and Radiology
Ultrasound Education Group	Co-director Professor Colin Royse Professor Alistair Royse	Surgery
Understanding antibiotic prescribing and use of guidelines in general practice – the GP National Antimicrobial Prescribing Survey (GP NAPS) pilot study	Principal Investigator Dr Jo-Anne Manski-Nankervis	General Practice
Understanding how Type 17 immunity and IL-17 cytokines regulate Type 1 diabetes	Dr Andrew Sutherland	Medicine and Radiology
Use of tools to detect medication related problems in emergency departments	Professor Elizabeth Manias	Psychiatry
Using the JAK1/JAK2 Inhibitor Baricitinib to treat new-onset Type 1 diabetes	Prof Helen Thomas	Medicine and Radiology
Vascular Health	Project Leader Professor Philippe Lehert	Medicine and Radiology
What are antigens/epitopes are recognized in by islet-infiltrating CD8+ T cells in people with type 1 diabetes?	A/Prof Stuart Mannering	Medicine and Radiology
You are what you eat? The gut microbiome and its regulation of heart disease	Dr Yung-Chih Chen	Baker Department of Cardiometabolic Health