POISE-3 Trial
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Principal Investigator
Professor Kate Leslie AO FAHMS
Project Details
PeriOperative ISchemic Evaluation-3 Trial: POISE-3
An international multi-centre randomized clinical trial to assess the impact of tranexamic acid (TXA) versus placebo, and to assess the impact of managing hypotension versus standard of care in patients undergoing non-cardiac surgery who are at risk of a perioperative cardiovascular event.
Ten thousand patients will be enrolled at 300 sites in 25 countries.
Primary objective: to determine the incidence of a composite of myocardial infarction, stroke and pulmonary embolism. Patients will be followed for 1 year.
Principal Investigator (Canada)
PJ Devereaux
Principal Investigator (Australia and New Zealand)
Professor Kate Leslie
Trial Manager (Australia and New Zealand)
Gillian Ormond
Follow POISE-3 on Twitter @POISE3_ANZ
Researchers
Prof Kate Leslie
Dr Thomas Painter
Prof Philip Devereaux
Prof Philip Peyton
Prof Tomas Corcoran
Dr Matthew Chan
A/Prof Timothy Short
Ms Gillan Ormond
Collaborators
Melbourne Health
Population Health Research Institute, McMaster University, Canada
Royal Adelaide Hospital
Royal Perth Hospital
Chinese University of Hong Kong
Auckland Hospital
Australian and New Zealand College of Anaesthetists Clinical Trials Network (ANZCA CTN)
Funding
NHMRC Project Grant $1,192,127 (2019-2023)