MINS Study
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Justin Nazareth
Project Details
MINS Study: Myocardial injury after noncardiac surgery sub-study of the VAPOR-C Trial
Hypothesis and aims
We hypothesise that the use of intraoperative intravenous lidocaine infusion during major surgery will reduce the incidence of MINS compared to placebo.
Primary aim:
1) To compare the incidence of MINS with the use of intraoperative intravenous lidocaine to placebo.
Endpoint definition: MINS will be defined as a Troponin level (Troponin I or Troponin T) greater than the 99th percentile of the upper reference limit, in accordance with the Fourth Universal Definition of Myocardial Infarction [24].
Secondary aim:
1) To measure the association between perioperative inflammatory changes, troponin rise, MINS and postoperative outcomes.
Endpoints: length of stay (days); postoperative complications and mortality at 30 days and 1 year. Perioperative inflammatory change will be measured by perioperative change in C-Reactive Protein (CRP), neutrophil-lymphocyte ratio (NLR) and inflammatory cytokines.
Study population
Participants recruited to the VAPOR-C Trial will be eligible for inclusion in the MINS Study and approached for recruitment.
Researchers
Chief Investigators
Dr Justin Nazareth
Dr Tim Coulson
Dr Julia Dubowitz
Professor Bernhard Riedel
Associate Investigators
Dr Mark Nolan
Professor Philip Peyton
Professor P J Devereaux
Funding
Australian and New Zealand College of Anaesthetists
Research Group
Anaesthesia, Perioperative and Pain Medicine
School Research Themes
Key Contact
For further information about this research, please contact the research group leader.
Department / Centre
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