POISE-3 Trial

Project Details

PeriOperative ISchemic Evaluation-3 Trial: POISE-3

An international multi-centre randomized clinical trial to assess the impact of tranexamic acid (TXA) versus placebo, and to assess the impact of managing hypotension versus standard of care in patients undergoing non-cardiac surgery who are at risk of a perioperative cardiovascular event.

Ten thousand patients will be enrolled at 300 sites in 25 countries.

Primary objective: to determine the incidence of a composite of myocardial infarction, stroke and pulmonary embolism. Patients will be followed for 1 year.

Principal Investigator (Canada)
PJ Devereaux

Principal Investigator (Australia and New Zealand)
Professor Kate Leslie

Trial Manager (Australia and New Zealand)
Gillian Ormond

Follow POISE-3 on Twitter @POISE3_ANZ


Prof Kate Leslie
Dr Thomas Painter
Prof Philip Devereaux
Prof Philip Peyton
Prof Tomas Corcoran 
Dr Matthew Chan
A/Prof Timothy Short
Ms Gillan Ormond


Melbourne Health
Population Health Research Institute, McMaster University, Canada
Royal Adelaide Hospital
Royal Perth Hospital
Chinese University of Hong Kong
Auckland Hospital
Australian and New Zealand College of Anaesthetists Clinical Trials Network (ANZCA CTN)


NHMRC Project Grant $1,192,127 (2019-2023)

Research Group

Anaesthesia, Perioperative and Pain Medicine

School Research Themes

Critical Care

Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Critical Care

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